Assessment of Structural Intolerance and Durability
General Structure Information 1x6f ZNF462 solution structures of the c2h2 type zinc finger domain of human zinc finger protein 462 -1.0Å AUTH M.SATO,K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE C2H2 TYPE ZINC FINGERTITL 2 DOMAIN OF HUMAN ZINC FINGER PROTEIN 462REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2eax PGLYRP4 crystal structure of human pgrp-ibetac in complex with glycosamyl muramyl pentapeptide 2.1Å AUTH S.CHO,Q.WANG,C.P.SWAMINATHAN,D.HESEK,M.LEE,G.J.BOONS,AUTH 2 S.MOBASHERY,R.A.MARIUZZATITL STRUCTURAL INSIGHTS INTO THE BACTERICIDAL MECHANISM OF HUMANTITL 2 PEPTIDOGLYCAN RECOGNITION PROTEINSREF PROC.NATL.ACAD.SCI.USA V. 104 8761 2007REFN ISSN 0027-8424PMID 17502600DOI 10.1073/PNAS.0701453104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1shz ARHGEF1 crystal structure of the p115rhogef rgrgs domain in a complex with galpha(13):galpha(i1) chimera 2.85Å AUTH Z.CHEN,W.D.SINGER,P.C.STERNWEIS,S.R.SPRANGTITL STRUCTURE OF THE P115RHOGEF RGRGSTITL 2 DOMAIN-GALPHA13/I1 CHIMERA COMPLEX SUGGESTSTITL 3 CONVERGENT EVOLUTION OF A GTPASE ACTIVATOR.REF NAT.STRUCT.MOL.BIOL. V. 12 191 2005REFN ISSN 1545-9993PMID 15665872DOI 10.1038/NSMB888 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2rnx KAT2B the structural basis for site-specific lysine-acetylated histone recognition by the bromodomains of the human transcriptional co-activators pcaf and cbp -1.0Å AUTH L.ZENG,Q.ZHANG,G.GERONA-NAVARRO,N.MOSHKINA,M.M.ZHOUTITL STRUCTURAL BASIS OF SITE-SPECIFIC HISTONETITL 2 RECOGNITION BY THE BROMODOMAINS OF HUMANTITL 3 COACTIVATORS PCAF AND CBP/P300REF STRUCTURE V. 16 643 2008REFN ISSN 0969-2126PMID 18400184DOI 10.1016/J.STR.2008.01.010 Variant Set […]
General Structure Information 2m17 UBLCP1 ubiquitin-like domain-containing c-terminal domain phosphatase (ublcp1) -1.0Å AUTH J.H.YUN,S.KO,C.K.LEE,H.K.CHEONG,C.CHEONG,J.B.YOON,W.LEETITL SOLUTION STRUCTURE AND RPN1 INTERACTION OF THE UBL DOMAIN OFTITL 2 HUMAN RNA POLYMERASE II C-TERMINAL DOMAIN PHOSPHATASE.REF PLOS ONE V. 8 62981 2013REFN ESSN 1932-6203PMID 23667555DOI 10.1371/JOURNAL.PONE.0062981 Variant Set Distributions Mapped Variants
General Structure Information 1wf6 TOPBP1 the third brca1 c-terminus (brct) domain of similar to s.pombe rad4+/cut5+ product -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL THE THIRD BRCA1 C-TERMINUS (BRCT) DOMAIN OFTITL 2 SIMILAR TO S.POMBE RAD4+/CUT5+ PRODUCTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2idx MMAB structure of human atp:cobalamin adenosyltransferase bound to atp. 2.5Å AUTH H.L.SCHUBERT,C.P.HILLTITL STRUCTURE OF ATP-BOUND HUMAN ATP:COBALAMINTITL 2 ADENOSYLTRANSFERASE.REF BIOCHEMISTRY V. 45 15188 2006REFN ISSN 0006-2960PMID 17176040DOI 10.1021/BI061396F Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3tdu DCUN1D1 n-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex: structure of a human cul1whb- dcn1p-acetylated ubc12n complex 1.5Å AUTH D.C.SCOTT,J.K.MONDA,E.J.BENNETT,J.W.HARPER,B.A.SCHULMANTITL N-TERMINAL ACETYLATION ACTS AS AN AVIDITY ENHANCER WITHIN ANTITL 2 INTERCONNECTED MULTIPROTEIN COMPLEX.REF SCIENCE V. 334 674 2011REFN ISSN 0036-8075PMID 21940857DOI 10.1126/SCIENCE.1209307 Variant Set Distributions Mapped Variants
General Structure Information 2l80 USP13 solution structure of the zinc finger domain of usp13 -1.0Å AUTH Y.ZHANG,A.SONG,C.ZHOU,Z.ZHOU,H.HUTITL BIOCHEMICAL CHARACTERIZATION OF THE UBIQUITIN RECEPTORS INTITL 2 USP13 REVEALS DIFFERENT CATALYTIC ACTIVATION OFTITL 3 DEUBIQUITINATION FROM ITS ANALOGUE USP5REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4ido ATL1 human atlastin-1 1-446, c-his6, gdpalf4- 2.09Å AUTH L.J.BYRNES,A.SINGH,K.SZETO,N.M.BENVIN,J.P.ODONNELL,AUTH 2 W.R.ZIPFEL,H.SONDERMANNTITL STRUCTURAL BASIS FOR CONFORMATIONAL SWITCHING AND GTPTITL 2 LOADING OF THE LARGE G PROTEIN ATLASTIN.REF EMBO J. V. 32 369 2013REFN ISSN 0261-4189PMID 23334294DOI 10.1038/EMBOJ.2012.353 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants