Assessment of Structural Intolerance and Durability
General Structure Information 4boc POLRMT structure of mitochondrial rna polymerase elongation complex 2.65Å AUTH K.SCHWINGHAMMER,A.C.M.CHEUNG,Y.I.MOROZOV,K.AGARONYAN,AUTH 2 D.TEMIAKOV,P.CRAMERTITL STRUCTURE OF HUMAN MITOCHONDRIAL RNA POLYMERASE ELONGATIONTITL 2 COMPLEXREF NAT.STRUCT.MOL.BIOL. V. 20 1298 2013REFN ISSN 1545-9993PMID 24096365DOI 10.1038/NSMB.2683 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1zjk MASP2 crystal structure of the zymogen catalytic region of human masp-2 2.18Å AUTH P.GAL,V.HARMAT,A.KOCSIS,T.BIAN,L.BARNA,G.AMBRUS,B.VEGH,AUTH 2 J.BALCZER,R.B.SIM,G.NARAY-SZABO,P.ZAVODSZKYTITL A TRUE AUTOACTIVATING ENZYME: STRUCTURAL INSIGHT INTOTITL 2 MANNOSE-BINDING LECTIN-ASSOCIATED SERINE PROTEASE-2TITL 3 ACTIVATIONSREF J.BIOL.CHEM. V. 280 33435 2005REFN ISSN 0021-9258PMID 16040602DOI 10.1074/JBC.M506051200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2wl1 MEFV pyrin pryspry domain 1.35Å AUTH C.WEINERT,C.GRUETTER,H.ROSCHITZKI-VOSER,P.R.MITTL,AUTH 2 M.G.GRUETTERTITL THE CRYSTAL STRUCTURE OF HUMAN PYRIN B30.2 DOMAIN:TITL 2 IMPLICATIONS FOR MUTATIONS ASSOCIATED WITHTITL 3 FAMILIAL MEDITERRANEAN FEVER.REF J.MOL.BIOL. V. 394 226 2009REFN ISSN 0022-2836PMID 19729025DOI 10.1016/J.JMB.2009.08.059 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vaf CASQ2 crystal structure of human cardiac calsequestrin 3.8Å AUTH E.KIM,B.YOUN,L.KEMPER,C.CAMPBELL,H.MILTING,AUTH 2 M.VARSANYI,C.KANGTITL CHARACTERIZATION OF HUMAN CARDIAC CALSEQUESTRINTITL 2 AND ITS DELETERIOUS MUTANTS.REF J.MOL.BIOL. V. 373 1047 2007REFN ISSN 0022-2836PMID 17881003DOI 10.1016/J.JMB.2007.08.055 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2r5t SGK1 crystal structure of inactive serum and glucocorticoid- regulated kinase 1 in complex with amp-pnp 1.9Å AUTH B.ZHAO,R.LEHR,A.M.SMALLWOOD,T.F.HO,K.MALEY,AUTH 2 T.RANDALL,M.S.HEAD,K.K.KORETKE,C.G.SCHNACKENBERGTITL CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF SERUMTITL 2 AND GLUCOCORTICOID-REGULATED KINASE 1 IN COMPLEXTITL 3 WITH AMP PNP.REF PROTEIN SCI. V. 16 2761 2007REFN ISSN 0961-8368PMID 17965184DOI 10.1110/PS.073161707 Variant Set […]
General Structure Information 2eqm PHF20L1 solution structure of the tudor domain of phd finger protein 20-like 1 [homo sapiens] -1.0Å AUTH W.DANG,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TARADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE TUDOR DOMAIN OF PHDTITL 2 FINGER PROTEIN 20-LIKE 1 [HOMO SAPIENS]REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3mtt PIK3R2 crystal structure of ish2 domain of human p85beta, northeast structural genomics consortium target hr5531c 3.3Å AUTH C.SCHAUDER,L.C.MA,R.M.KRUG,G.T.MONTELIONE,R.GUANTITL STRUCTURE OF THE ISH2 DOMAIN OF HUMAN PHOSPHATIDYLINOSITOLTITL 2 3-KINASE P85BETA SUBUNIT REVEALS CONFORMATIONAL PLASTICITYTITL 3 IN THE INTERHELICAL TURN REGIONREF ACTA CRYSTALLOGR.,SECT.F V. 66 1567 2010REFN ESSN 1744-3091PMID 21139197DOI 10.1107/S1744309110041333 Variant Set […]
General Structure Information 2b2t CHD1 tandem chromodomains of human chd1 complexed with histone h3 tail containing trimethyllysine 4 and phosphothreonine 3 2.45Å AUTH J.F.FLANAGAN,L.Z.MI,M.CHRUSZCZ,M.CYMBOROWSKI,AUTH 2 K.L.CLINES,Y.KIM,W.MINOR,F.RASTINEJAD,AUTH 3 S.KHORASANIZADEHTITL DOUBLE CHROMODOMAINS COOPERATE TO RECOGNIZE THETITL 2 METHYLATED HISTONE H3 TAIL.REF NATURE V. 438 1181 2005REFN ISSN 0028-0836PMID 16372014DOI 10.1038/NATURE04290 Variant Set Distributions Mapped Variants
General Structure Information 1uf0 DCLK1 solution structure of the n-terminal dcx domain of human doublecortin-like kinase -1.0Å AUTH K.SAITO,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERMINAL DCX DOMAIN OFTITL 2 HUMAN DOUBLECORTIN-LIKE KINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ydj CHEK1 discovery of checkpoint kinase inhibitor azd7762 by structure based design and optimization of thiophene carboxamide ureas 1.85Å AUTH V.OZA,S.ASHWELL,L.ALMEIDA,P.BRASSIL,J.BREED,C.DENG,T.GERO,AUTH 2 M.GRONDINE,C.HORN,S.IOANNIDIS,D.LIU,P.LYNE,N.NEWCOMBE,AUTH 3 M.PASS,J.A.READ,S.READY,S.ROWSELL,M.SU,D.TOADER,M.VASBINDER,AUTH 4 D.YU,Y.YU,Y.XUE,S.ZABLUDOFF,J.JANETKATITL DISCOVERY OF CHECKPOINT KINASE INHIBITOR (S)-5-(3-TITL 2 FLUOROPHENYL)-N-(PIPERIDIN-3-YL)-3-UREIDOTHIOPHENE-2-TITL 3 CARBOXAMIDE (AZD7762) BY STRUCTURE-BASED DESIGN ANDTITL 4 OPTIMIZATION OF THIOPHENECARBOXAMIDE UREAS.REF J.MED.CHEM. V. 55 5130 2012REFN […]