Assessment of Structural Intolerance and Durability
General Structure Information 4drb STRA13 the crystal structure of fancm bound mhf complex 2.63Å AUTH Y.TAO,C.JIN,X.LI,S.QI,L.CHU,L.NIU,X.YAO,M.TENGTITL THE STRUCTURE OF THE FANCM-MHF COMPLEX REVEALS PHYSICALTITL 2 FEATURES FOR FUNCTIONAL ASSEMBLYREF NAT COMMUN V. 3 782 2012REFN ESSN 2041-1723PMID 22510687DOI 10.1038/NCOMMS1779 Variant Set Distributions Mapped Variants
General Structure Information 2jun MID1 structure of the mid1 tandem b-boxes reveals an interaction reminiscent of intermolecular ring heterodimers -1.0Å AUTH H.TAO,B.N.SIMMONS,S.SINGIREDDY,M.JAKKIDI,K.M.SHORT,AUTH 2 T.C.COX,M.A.MASSIAHTITL STRUCTURE OF THE MID1 TANDEM B-BOXES REVEALS ANTITL 2 INTERACTION REMINISCENT OF INTERMOLECULAR RINGTITL 3 HETERODIMERSREF BIOCHEMISTRY V. 47 2450 2008REFN ISSN 0006-2960PMID 18220417DOI 10.1021/BI7018496 Variant Set Distributions Mapped Variants
General Structure Information 3sua PLXNB1 crystal structure of the intracellular domain of plexin-b1 in complex with rac1 4.39Å AUTH C.H.BELL,A.R.ARICESCU,E.Y.JONES,C.SIEBOLDTITL A DUAL BINDING MODE FOR RHOGTPASES IN PLEXIN SIGNALLING.REF PLOS BIOL. V. 9 01134 2011REFN ISSN 1544-9173PMID 21912513DOI 10.1371/JOURNAL.PBIO.1001134 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2r0o ACTN4 crystal structure of the actin-binding domain of human alpha-actinin-4 mutant(k255e) 2.2Å AUTH S.H.LEE,A.WEINS,D.B.HAYES,M.R.POLLAK,R.DOMINGUEZTITL CRYSTAL STRUCTURE OF THE ACTIN-BINDING DOMAIN OFTITL 2 ALPHA-ACTININ-4 LYS255GLU MUTANT IMPLICATED IN FOCALTITL 3 SEGMENTAL GLOMERULOSCLEROSIS.REF J.MOL.BIOL. V. 376 317 2008REFN ISSN 0022-2836PMID 18164029DOI 10.1016/J.JMB.2007.11.084 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fqg TCERG1 crystal structure of the tcerg1 ff4-6 tandem repeat domain 2.0Å AUTH J.LIU,S.FAN,C.J.LEE,A.L.GREENLEAF,P.ZHOUTITL SPECIFIC INTERACTION OF THE TRANSCRIPTION ELONGATIONTITL 2 REGULATOR TCERG1 WITH RNA POLYMERASE II REQUIRESTITL 3 SIMULTANEOUS PHOSPHORYLATION AT SER2, SER5, AND SER7 WITHINTITL 4 THE CARBOXYL-TERMINAL DOMAIN REPEAT.REF J.BIOL.CHEM. V. 288 10890 2013REFN ISSN 0021-9258PMID 23436654DOI 10.1074/JBC.M113.460238 Variant […]
General Structure Information 1kwa CASK human cask/lin-2 pdz domain 1.93Å AUTH D.L.DANIELS,A.R.COHEN,J.M.ANDERSON,A.T.BRUNGERTITL CRYSTAL STRUCTURE OF THE HCASK PDZ DOMAIN REVEALSTITL 2 THE STRUCTURAL BASIS OF CLASS II PDZ DOMAIN TARGETTITL 3 RECOGNITIONREF NAT.STRUCT.BIOL. V. 5 317 1998REFN ISSN 1072-8368PMID 9546224DOI 10.1038/NSB0498-317 Variant Set Distributions Mapped Variants
General Structure Information 3ner CYB5B structure of human type b cytochrome b5 1.45Å AUTH S.PARTHASARATHY,A.ALTUVE,S.TERZYAN,X.ZHANG,K.KUCZERA,AUTH 2 M.RIVERA,D.R.BENSONTITL ACCOMMODATING A NON-CONSERVATIVE INTERNAL MUTATION BYTITL 2 WATER-MEDIATED HYDROGEN-BONDING BETWEEN BETA-SHEET STRANDS:TITL 3 A COMPARISON OF HUMAN AND RAT TYPE B (MITOCHONDRIAL)TITL 4 CYTOCHROME B5REF BIOCHEMISTRY V. 50 5544 2011REFN ISSN 0006-2960PMID 21574570DOI 10.1021/BI2004729 Variant Set Distributions Mapped […]
General Structure Information 1wzv UBE2L6 crystal structure of ubch8 2.1Å AUTH T.MIZUSHIMA,M.SUZUKI,N.TESHIMA,T.YAMANE,S.MURATA,AUTH 2 K.TANAKATITL CRYSTAL STRUCTURE OF UBCH8REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3gb8 XPO1 crystal structure of crm1/snurportin-1 complex 2.9Å AUTH X.DONG,A.BISWAS,K.E.SUEL,L.K.JACKSON,R.MARTINEZ,H.GU,AUTH 2 Y.M.CHOOKTITL STRUCTURAL BASIS FOR LEUCINE-RICH NUCLEAR EXPORT SIGNALTITL 2 RECOGNITION BY CRM1.REF NATURE V. 458 1136 2009REFN ISSN 0028-0836PMID 19339969DOI 10.1038/NATURE07975 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4f8t BTN3A3 crystal structure of the human btn3a3 ectodomain 2.38Å AUTH A.PALAKODETI,A.SANDSTROM,L.SUNDARESAN,C.HARLY,S.NEDELLEC,AUTH 2 D.OLIVE,E.SCOTET,M.BONNEVILLE,E.J.ADAMSTITL THE MOLECULAR BASIS FOR MODULATION OF HUMANTITL 2 V(GAMMA)9V(DELTA)2 T CELL RESPONSE BY CD277/BUTRYOPHILINTITL 3 (BTN3A)-SPECIFIC ANTIBODIESREF J.BIOL.CHEM. V. 287 32780 2012REFN ISSN 0021-9258PMID 22846996DOI 10.1074/JBC.M112.384354 Variant Set Distributions Mapped Variants