Assessment of Structural Intolerance and Durability
General Structure Information 2ila IL1A structure of interleukin 1alpha at 2.7-angstroms resolution 2.3Å AUTH B.J.GRAVES,M.H.HATADA,W.A.HENDRICKSON,J.K.MILLER,AUTH 2 V.S.MADISON,Y.SATOWTITL STRUCTURE OF INTERLEUKIN 1 ALPHA AT 2.7-ATITL 2 RESOLUTION.REF BIOCHEMISTRY V. 29 2679 1990REFN ISSN 0006-2960PMID 2346741DOI 10.1021/BI00463A009 Variant Set Distributions Mapped Variants
General Structure Information 2wnv C1QC complex between c1q globular heads and deoxyribose 1.25Å AUTH V.GARLATTI,A.CHOUQUET,T.LUNARDI,R.VIVES,H.PAIDASSI,AUTH 2 H.LORTAT-JACOB,N.M.THIELENS,G.J.ARLAUD,C.GABORIAUDTITL CUTTING EDGE: C1Q BINDS DEOXYRIBOSE AND HEPARANTITL 2 SULFATE THROUGH NEIGHBORING SITES OF ITSTITL 3 RECOGNITION DOMAIN.REF J.IMMUNOL. V. 185 808 2010REFN ISSN 0022-1767PMID 20548024DOI 10.4049/JIMMUNOL.1000184 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1lj7 CRP crystal structure of calcium-depleted human c-reactive protein from perfectly twinned data 3.15Å AUTH M.A.RAMADAN,A.K.SHRIVE,D.HOLDEN,D.A.MYLES,AUTH 2 J.E.VOLANAKIS,L.J.DELUCAS,T.J.GREENHOUGHTITL THE THREE-DIMENSIONAL STRUCTURE OFTITL 2 CALCIUM-DEPLETED HUMAN C-REACTIVE PROTEIN FROMTITL 3 PERFECTLY TWINNED CRYSTALS.REF ACTA CRYSTALLOGR.,SECT.D V. 58 992 2002REFN ISSN 0907-4449PMID 12037301DOI 10.1107/S0907444902005693 Variant Set Distributions Mapped Variants
General Structure Information 1alu IL6 human interleukin-6 1.9Å AUTH W.SOMERS,M.STAHL,J.S.SEEHRATITL 1.9 A CRYSTAL STRUCTURE OF INTERLEUKIN 6: IMPLICATIONS FOR ATITL 2 NOVEL MODE OF RECEPTOR DIMERIZATION AND SIGNALING.REF EMBO J. V. 16 989 1997REFN ISSN 0261-4189PMID 9118960DOI 10.1093/EMBOJ/16.5.989 Variant Set Distributions Mapped Variants
General Structure Information 1q8k EIF2S1 solution structure of alpha subunit of human eif2 -1.0Å AUTH T.ITO,A.MARINTCHEV,G.WAGNERTITL SOLUTION STRUCTURE OF HUMAN INITIATION FACTORTITL 2 EIF2ALPHA REVEALS HOMOLOGY TO THE ELONGATIONTITL 3 FACTOR EEF1B.REF STRUCTURE V. 12 1693 2004REFN ISSN 0969-2126PMID 15341733DOI 10.1016/J.STR.2004.07.010 Variant Set Distributions Mapped Variants
General Structure Information 1eer EPO crystal structure of human erythropoietin complexed to its receptor at 1.9 angstroms 1.9Å AUTH R.S.SYED,S.W.REID,C.LI,J.C.CHEETHAM,K.H.AOKI,B.LIU,AUTH 2 H.ZHAN,T.D.OSSLUND,A.J.CHIRINO,J.ZHANG,AUTH 3 J.FINER-MOORE,S.ELLIOTT,K.SITNEY,B.A.KATZ,AUTH 4 D.J.MATTHEWS,J.J.WENDOLOSKI,J.EGRIE,R.M.STROUDTITL EFFICIENCY OF SIGNALLING THROUGH CYTOKINETITL 2 RECEPTORS DEPENDS CRITICALLY ON RECEPTORTITL 3 ORIENTATION.REF NATURE V. 395 511 1998REFN ISSN 0028-0836PMID 9774108DOI 10.1038/26773 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4dkk STAU1 the x-ray crystal structure of the human stau1 ssm-rbd5 domain- swapped dimer 1.7Å AUTH M.L.GLEGHORN,C.GONG,C.L.KIELKOPF,L.E.MAQUATTITL STAUFEN1 DIMERIZES THROUGH A CONSERVED MOTIF AND ATITL 2 DEGENERATE DSRNA-BINDING DOMAIN TO PROMOTE MRNA DECAY.REF NAT.STRUCT.MOL.BIOL. V. 20 515 2013REFN ISSN 1545-9993PMID 23524536DOI 10.1038/NSMB.2528 Variant Set Distributions Mapped Variants
General Structure Information 4ijq HPRT1 human hypoxanthine-guanine phosphoribosyltransferase in complex with [(2-((guanine-9h-yl)methyl)propane-1,3-diyl)bis(oxy)]bis(methylene)) diphosphonic acid 2.0Å AUTH D.T.KEOUGH,P.SPACEK,D.HOCKOVA,T.TICHY,S.VRBKOVA,AUTH 2 L.SLAVETINSKA,Z.JANEBA,L.NAESENS,M.D.EDSTEIN,M.CHAVCHICH,AUTH 3 T.H.WANG,J.JERSEY,L.W.GUDDATTITL ACYCLIC NUCLEOSIDE PHOSPHONATES CONTAINING A SECONDTITL 2 PHOSPHONATE GROUP ARE POTENT INHIBITORS OF 6-OXOPURINETITL 3 PHOSPHORIBOSYLTRANSFERASES AND HAVE ANTIMALARIAL ACTIVITYREF J.MED.CHEM. V. 56 2513 2013REFN ISSN 0022-2623PMID 23448281DOI 10.1021/JM301893B Variant Set Distributions Pathogenic Proximity […]
General Structure Information 1o9a FN1 solution structure of the complex of 1f12f1 from fibronectin with b3 from fnbb from s. dysgalactiae -1.0Å AUTH U.SCHWARZ-LINEK,J.M.WERNER,A.R.PICKFORD,S.GURUSIDDAPPA,AUTH 2 J.H.KIM,E.S.PILKA,J.A.G.BRIGGS,T.S.GOUGH,M.HOOK,AUTH 3 I.D.CAMPBELL,J.R.POTTSTITL PATHOGENIC BACTERIA ATTACH TO HUMAN FIBRONECTIN THROUGH ATITL 2 TANDEM BETA-ZIPPER.REF NATURE V. 423 177 2003REFN ISSN 0028-0836PMID 12736686DOI 10.1038/NATURE01589 Variant Set Distributions Mapped Variants
General Structure Information 1n7d LDLR extracellular domain of the ldl receptor 3.7Å AUTH G.RUDENKO,L.HENRY,K.HENDERSON,K.ICHTCHENKO,M.S.BROWN,AUTH 2 J.L.GOLDSTEIN,J.DEISENHOFERTITL STRUCTURE OF THE LDL RECEPTOR EXTRACELLULAR DOMAIN ATTITL 2 ENDOSOMAL PHREF SCIENCE V. 298 2353 2002REFN ISSN 0036-8075PMID 12459547DOI 10.1126/SCIENCE.1078124 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants