Assessment of Structural Intolerance and Durability
General Structure Information 2rmn TP63 the solution structure of the p63 dna-binding domain -1.0Å AUTH A.ENTHART,J.FURRER,A.DEHNER,H.KESSLERTITL SOLUTION STRUCTURE AND BINDING STUDIES OF THE P63TITL 2 DNA BINDING DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3o4o IL1RAP crystal structure of an interleukin-1 receptor complex 3.3Å AUTH D.L.WANG,S.Y.ZHANG,L.LI,X.LIU,K.R.MEI,X.Q.WANGTITL STRUCTURAL INSIGHTS INTO THE ASSEMBLY AND ACTIVATION OFTITL 2 IL-1BETA WITH ITS RECEPTORSREF NAT.IMMUNOL. V. 11 905 2010REFN ISSN 1529-2908PMID 20802483DOI 10.1038/NI.1925 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ihx PRDM10 methyltransferase domain of human pr domain-containing protein 10 2.5Å AUTH M.F.AMAYA,L.DOMBROVSKI,S.NI,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOTCHKAREV,J.MIN,A.N.PLOTNIKOV,AUTH 3 H.WU,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL METHYLTRANSFERASE DOMAIN OF HUMAN PR DOMAIN-CONTAININGTITL 2 PROTEIN 10REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2khx DROSHA drosha double-stranded rna binding motif -1.0Å AUTH G.A.MUELLER,M.T.MILLER,E.F.DEROSE,M.GHOSH,R.E.LONDON,AUTH 2 T.M.HALLTITL SOLUTION STRUCTURE OF THE DROSHA DOUBLE-STRANDED RNA-BINDINGTITL 2 DOMAIN.REF SILENCE V. 1 2 2010REFN ESSN 1758-907XPMID 20226070DOI 10.1186/1758-907X-1-2 Variant Set Distributions Mapped Variants
General Structure Information 1y96 GEMIN7 crystal structure of the gemin6/gemin7 heterodimer from the human smn complex 2.0Å AUTH Y.MA,J.DOSTIE,G.DREYFUSS,G.D.VAN DUYNETITL THE GEMIN6-GEMIN7 HETERODIMER FROM THE SURVIVAL OFTITL 2 MOTOR NEURONS COMPLEX HAS AN SM PROTEIN-LIKETITL 3 STRUCTURE.REF STRUCTURE V. 13 883 2005REFN ISSN 0969-2126PMID 15939020DOI 10.1016/J.STR.2005.03.014 Variant Set Distributions Mapped Variants
General Structure Information 4bx9 VPS16 human vps33a in complex with a fragment of human vps16 2.6Å AUTH S.C.GRAHAM,L.WARTOSCH,S.R.GRAY,E.J.SCOURFIELD,J.E.DEANE,AUTH 2 J.P.LUZIO,D.J.OWENTITL STRUCTURAL BASIS OF VPS33A RECRUITMENT TO THE HUMAN HOPSTITL 2 COMPLEX BY VPS16.REF PROC.NATL.ACAD.SCI.USA V. 110 13345 2013REFN ISSN 0027-8424PMID 23901104DOI 10.1073/PNAS.1307074110 Variant Set Distributions Mapped Variants
General Structure Information 3d2n MBNL1 crystal structure of mbnl1 tandem zinc finger 1 and 2 domain 2.7Å AUTH M.TEPLOVA,D.J.PATELTITL STRUCTURAL INSIGHTS INTO RNA RECOGNITION BY THETITL 2 ALTERNATIVE-SPLICING REGULATOR MUSCLEBLIND-LIKETITL 3 MBNL1.REF NAT.STRUCT.MOL.BIOL. V. 15 1343 2008REFN ISSN 1545-9993PMID 19043415DOI 10.1038/NSMB.1519 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2li8 LIN28A the solution structure of the lin28-znf domains bound to aggagau of pre-let-7 mirna -1.0Å AUTH F.E.LOUGHLIN,L.F.GEBERT,H.TOWBIN,A.BRUNSCHWEIGER,J.HALL,AUTH 2 F.H.ALLAINTITL STRUCTURAL BASIS OF PRE-LET-7 MIRNA RECOGNITION BY THE ZINCTITL 2 KNUCKLES OF PLURIPOTENCY FACTOR LIN28.REF NAT.STRUCT.MOL.BIOL. V. 19 84 2011REFN ISSN 1545-9993PMID 22157959DOI 10.1038/NSMB.2202 Variant Set Distributions Mapped Variants
General Structure Information 2cpd A1CF solution structure of the rna recognition motif of human apobec-1 complementation factor, acf -1.0Å AUTH T.NAGATA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RNA RECOGNITION MOTIF OFTITL 2 HUMAN APOBEC-1 COMPLEMENTATION FACTOR, ACFREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1mu9 TDP1 crystal structure of a human tyrosyl-dna phosphodiesterase (tdp1)- vanadate complex 2.05Å AUTH D.R.DAVIES,H.INTERTHAL,J.J.CHAMPOUX,W.G.J.HOLTITL INSIGHTS INTO SUBSTRATE BINDING AND CATALYTIC MECHANISM OFTITL 2 HUMAN TYROSYL-DNA PHOSPHODIESTERASE (TDP1) FROM VANADATE-TITL 3 AND TUNGSTATE-INHIBITED STRUCTURESREF J.MOL.BIOL. V. 324 917 2002REFN ISSN 0022-2836PMID 12470949DOI 10.1016/S0022-2836(02)01154-3 Variant Set Distributions Mapped Variants