Assessment of Structural Intolerance and Durability
General Structure Information 1lfi LTF metal substitution in transferrins: the crystal structure of human copper-lactoferrin at 2.1 angstroms resolution 2.1Å AUTH C.A.SMITH,B.F.ANDERSON,H.M.BAKER,E.N.BAKERTITL METAL SUBSTITUTION IN TRANSFERRINS: THE CRYSTAL STRUCTURE OFTITL 2 HUMAN COPPER-LACTOFERRIN AT 2.1-A RESOLUTION.REF BIOCHEMISTRY V. 31 4527 1992REFN ISSN 0006-2960PMID 1581307DOI 10.1021/BI00133A020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3s9d IFNA2 binary complex between ifna2 and ifnar2 2.0Å AUTH C.THOMAS,I.MORAGA,D.LEVIN,P.O.KRUTZIK,Y.PODOPLELOVA,A.TREJO,AUTH 2 C.LEE,G.YARDEN,S.E.VLECK,J.S.GLENN,G.P.NOLAN,J.PIEHLER,AUTH 3 G.SCHREIBER,K.C.GARCIATITL STRUCTURAL LINKAGE BETWEEN LIGAND DISCRIMINATION ANDTITL 2 RECEPTOR ACTIVATION BY TYPE I INTERFERONS.REF CELL(CAMBRIDGE,MASS.) V. 146 621 2011REFN ISSN 0092-8674PMID 21854986DOI 10.1016/J.CELL.2011.06.048 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1xwe C5 nmr structure of c345c (ntr) domain of c5 of complement -1.0Å AUTH J.BRAMHAM,C.-T.THAI,D.C.SOARES,D.UHRIN,R.T.OGATA,AUTH 2 P.N.BARLOWTITL FUNCTIONAL INSIGHTS FROM THE STRUCTURE OF THETITL 2 MULTIFUNCTIONAL C345C DOMAIN OF C5 OF COMPLEMENTREF J.BIOL.CHEM. V. 280 10636 2005REFN ISSN 0021-9258PMID 15598652DOI 10.1074/JBC.M413126200 Variant Set Distributions Mapped Variants
General Structure Information 2ach SERPINA3 crystal structure of cleaved human alpha1-antichymotrypsin at 2.7 angstroms resolution and its comparison with other serpins 2.7Å AUTH U.BAUMANN,R.HUBER,W.BODE,D.GROSSE,M.LESJAK,C.B.LAURELLTITL CRYSTAL STRUCTURE OF CLEAVED HUMAN ALPHA 1-ANTICHYMOTRYPSINTITL 2 AT 2.7 A RESOLUTION AND ITS COMPARISON WITH OTHER SERPINS.REF J.MOL.BIOL. V. 218 595 1991REFN ISSN 0022-2836PMID 2016749DOI 10.1016/0022-2836(91)90704-A Variant Set Distributions Mapped […]
General Structure Information 3umi APP x-ray structure of the e2 domain of the human amyloid precursor protein (app) in complex with zinc 2.4Å AUTH S.O.DAHMS,I.KONNIG,D.ROESER,K.H.GUHRS,M.C.MAYER,D.KADEN,AUTH 2 G.MULTHAUP,M.E.THANTITL METAL BINDING DICTATES CONFORMATION AND FUNCTION OF THETITL 2 AMYLOID PRECURSOR PROTEIN (APP) E2 DOMAIN.REF J.MOL.BIOL. V. 416 438 2012REFN ISSN 0022-2836PMID 22245578DOI 10.1016/J.JMB.2011.12.057 Variant Set Distributions Ripley’s […]
General Structure Information 2v3s OXSR1 structural insights into the recognition of substrates and activators by the osr1 kinase 1.7Å AUTH F.VILLA,J.GOEBEL,F.H.RAFIQI,M.DEAK,J.THASTRUP,AUTH 2 D.R.ALESSI,D.M.F.VAN AALTENTITL STRUCTURAL INSIGHTS INTO THE RECOGNITION OFTITL 2 SUBSTRATES AND ACTIVATORS BY THE OSR1 KINASEREF EMBO REP. V. 8 839 2007REFN ISSN 1469-3178PMID 17721439DOI 10.1038/SJ.EMBOR.7401048 Variant Set Distributions Mapped Variants
General Structure Information 1uea TIMP1 mmp-3/timp-1 complex 2.8Å AUTH F.X.GOMIS-RUTH,K.MASKOS,M.BETZ,A.BERGNER,R.HUBER,AUTH 2 K.SUZUKI,N.YOSHIDA,H.NAGASE,K.BREW,G.P.BOURENKOV,AUTH 3 H.BARTUNIK,W.BODETITL MECHANISM OF INHIBITION OF THE HUMAN MATRIXTITL 2 METALLOPROTEINASE STROMELYSIN-1 BY TIMP-1.REF NATURE V. 389 77 1997REFN ISSN 0028-0836PMID 9288970DOI 10.1038/37995 Variant Set Distributions Mapped Variants
General Structure Information 2wnu C1QA complex between c1q globular heads and heparan sulfate 2.3Å AUTH V.GARLATTI,A.CHOUQUET,T.LUNARDI,R.VIVES,H.PAIDASSI,AUTH 2 H.LORTAT-JACOB,N.M.THIELENS,G.J.ARLAUD,C.GABORIAUDTITL CUTTING EDGE: C1Q BINDS DEOXYRIBOSE AND HEPARANTITL 2 SULFATE THROUGH NEIGHBORING SITES OF ITSTITL 3 RECOGNITION DOMAIN.REF J.IMMUNOL. V. 185 808 2010REFN ISSN 0022-1767PMID 20548024DOI 10.4049/JIMMUNOL.1000184 Variant Set Distributions Mapped Variants
General Structure Information 3mjg PDGFB the structure of a platelet derived growth factor receptor complex 2.3Å AUTH A.H.SHIM,H.LIU,P.J.FOCIA,X.CHEN,P.C.LIN,X.HETITL STRUCTURES OF A PLATELET-DERIVED GROWTH FACTOR/PROPEPTIDETITL 2 COMPLEX AND A PLATELET-DERIVED GROWTH FACTOR/RECEPTORTITL 3 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 107 11307 2010REFN ISSN 0027-8424PMID 20534510DOI 10.1073/PNAS.1000806107 Variant Set Distributions Mapped Variants
General Structure Information 3iar ADA the crystal structure of human adenosine deaminase 1.52Å AUTH E.UGOCHUKWU,Y.ZHANG,E.HAPKA,W.W.YUE,J.E.BRAY,J.MUNIZ,AUTH 2 N.BURGESS-BROWN,A.CHAIKUAD,K.L.KAVANAGH,U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN ADENOSINE DEAMINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants