Assessment of Structural Intolerance and Durability
General Structure Information 4g1t IFIT2 crystal structure of interferon-stimulated gene 54 2.8Å AUTH Z.YANG,H.LIANG,Q.ZHOU,Y.LI,H.CHEN,W.YE,D.CHEN,J.FLEMING,AUTH 2 H.SHU,Y.LIUTITL CRYSTAL STRUCTURE OF ISG54 REVEALS A NOVEL RNA BINDINGTITL 2 STRUCTURE AND POTENTIAL FUNCTIONAL MECHANISMS.REF CELL RES. 2012REFN ISSN 1001-0602PMID 22825553DOI 10.1038/CR.2012.111 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2uzx MET structure of the human receptor tyrosine kinase met in complex with the listeria monocytogenes invasion protein inlb: crystal form i 2.8Å AUTH H.H.NIEMANN,V.JAGER,P.J.G.BUTLER,J.VAN DEN HEUVEL,AUTH 2 S.SCHMIDT,D.FERRARIS,E.GHERARDI,D.W.HEINZTITL STRUCTURE OF THE HUMAN RECEPTOR TYROSINE KINASETITL 2 MET IN COMPLEX WITH THE LISTERIA INVASION PROTEINTITL 3 INLBREF CELL(CAMBRIDGE,MASS.) V. 130 235 2007REFN […]
General Structure Information 3w14 INSR insulin receptor ectodomain construct comprising domains l1,cr,l2, fniii-1 and alphact peptide in complex with bovine insulin and fab 83-14 4.4Å AUTH J.G.MENTING,J.WHITTAKER,M.B.MARGETTS,L.J.WHITTAKER,AUTH 2 G.K.-W.KONG,B.J.SMITH,C.J.WATSON,L.ZAKOVA,E.KLETVIKOVA,AUTH 3 J.JIRACEK,S.J.CHAN,D.F.STEINER,G.G.DODSON,A.M.BRZOZOWSKI,AUTH 4 M.A.WEISS,C.W.WARD,M.C.LAWRENCETITL HOW INSULIN ENGAGES ITS PRIMARY BINDING SITE ON THE INSULINTITL 2 RECEPTORREF NATURE V. 493 241 2013REFN ISSN 0028-0836PMID 23302862DOI 10.1038/NATURE11781 Variant […]
General Structure Information 1fik PFN1 human platelet profilin i crystallized in low salt 2.3Å AUTH A.A.FEDOROV,T.D.POLLARD,S.C.ALMOTITL CRYSTAL STRUCTURE OF HUMAN PROFILIN AT 2.0TITL 2 ANGSTROMS RESOLUTIONREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1k9k S100A6 crystal structure of calcium bound human s100a6 1.76Å AUTH L.R.OTTERBEIN,J.KORDOWSKA,C.WITTE-HOFFMANN,AUTH 2 C.L.WANG,R.DOMINGUEZTITL CRYSTAL STRUCTURES OF S100A6 IN THE CA(2+)-FREETITL 2 AND CA(2+)-BOUND STATES: THE CALCIUM SENSORTITL 3 MECHANISM OF S100 PROTEINS REVEALED AT ATOMICTITL 4 RESOLUTION.REF STRUCTURE V. 10 557 2002REFN ISSN 0969-2126PMID 11937060DOI 10.1016/S0969-2126(02)00740-2 Variant Set Distributions Mapped Variants
General Structure Information 2hb8 VDR crystal structure of vdr lbd in complex with 2alpha-methyl calcitriol 2.0Å AUTH S.HOURAI,T.FUJISHIMA,A.KITTAKA,Y.SUHARA,H.TAKAYAMA,AUTH 2 N.ROCHEL,D.MORASTITL PROBING A WATER CHANNEL NEAR THE A-RING OFTITL 2 RECEPTOR-BOUND 1ALPHA,25-DIHYDROXYVITAMIN D3 WITHTITL 3 SELECTED 2ALPHA-SUBSTITUTED ANALOGUESREF J.MED.CHEM. V. 49 5199 2006REFN ISSN 0022-2623PMID 16913708DOI 10.1021/JM0604070 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2vh7 ACYP1 crystal structure of human common-type acylphosphatase 1.45Å AUTH S.Y.LAM,R.C.Y.YEUNG,T.YU,K.SZE,K.B.WONGTITL A RIGIDIFYING SALT-BRIDGE FAVORS THE ACTIVITY OFTITL 2 THERMOPHILIC ENZYME AT HIGH TEMPERATURES AT THE EXPENSE OFTITL 3 LOW-TEMPERATURE ACTIVITY.REF PLOS BIOL. V. 9 1027 2011REFN ISSN 1544-9173PMID 21423654DOI 10.1371/JOURNAL.PBIO.1001027 Variant Set Distributions Mapped Variants
General Structure Information 4dy0 SERPINE2 crystal structure of native protease nexin-1 with heparin 2.35Å AUTH W.LI,J.A.HUNTINGTONTITL CRYSTAL STRUCTURES OF PROTEASE NEXIN-1 IN COMPLEX WITHTITL 2 HEPARIN AND THROMBIN SUGGEST A 2-STEP RECOGNITION MECHANISM.REF BLOOD V. 120 459 2012REFN ISSN 0006-4971PMID 22618708DOI 10.1182/BLOOD-2012-03-415869 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1z00 ERCC1 solution structure of the c-terminal domain of ercc1 complexed with the c-terminal domain of xpf -1.0Å AUTH K.TRIPSIANES,G.FOLKERS,E.AB,D.DAS,H.ODIJK,AUTH 2 N.G.J.JASPERS,J.H.J.HOEIJMAKERS,R.KAPTEIN,R.BOELENSTITL THE STRUCTURE OF THE HUMAN ERCC1/XPF INTERACTIONTITL 2 DOMAINS REVEALS A COMPLEMENTARY ROLE FOR THE TWOTITL 3 PROTEINS IN NUCLEOTIDE EXCISION REPAIRREF STRUCTURE V. 13 1849 2005REFN ISSN 0969-2126PMID 16338413DOI […]
General Structure Information 1ux6 THBS1 structure of a thrombospondin c-terminal fragment reveals a novel calcium core in the type 3 repeats 1.9Å AUTH M.KVANSAKUL,J.C.ADAMS,E.HOHENESTERTITL STRUCTURE OF A THROMBOSPONDIN C-TERMINAL FRAGMENTTITL 2 REVEALS A NOVEL CALCIUM CORE IN THE TYPE 3 REPEATSREF EMBO J. V. 23 1223 2004REFN ISSN 0261-4189PMID 15014436DOI 10.1038/SJ.EMBOJ.7600166 Variant Set Distributions Ripley’s […]