Assessment of Structural Intolerance and Durability
General Structure Information 1deu CTSZ crystal structure of human procathepsin x: a cysteine protease with the proregion covalently linked to the active site cysteine 1.7Å AUTH J.SIVARAMAN,D.K.NAGLER,R.ZHANG,R.MENARD,M.CYGLERTITL CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN X: A CYSTEINETITL 2 PROTEASE WITH THE PROREGION COVALENTLY LINKED TO THE ACTIVETITL 3 SITE CYSTEINE.REF J.MOL.BIOL. V. 295 939 2000REFN ISSN 0022-2836PMID […]
General Structure Information 2rjq ADAMTS5 crystal structure of adamts5 with inhibitor bound 2.6Å AUTH L.MOSYAK,K.GEORGIADIS,T.SHANE,K.SVENSON,T.HEBERT,T.MCDONAGH,AUTH 2 S.MACKIE,S.OLLAND,L.LIN,X.ZHONG,R.KRIZ,E.L.REIFENBERG,AUTH 3 L.A.COLLINS-RACIE,C.CORCORAN,B.FREEMAN,R.ZOLLNER,T.MARVELL,AUTH 4 M.VERA,P.E.SUM,E.R.LAVALLIE,M.STAHL,W.SOMERSTITL CRYSTAL STRUCTURES OF THE TWO MAJOR AGGRECAN DEGRADINGTITL 2 ENZYMES, ADAMTS4 AND ADAMTS5.REF PROTEIN SCI. V. 17 16 2008REFN ISSN 0961-8368PMID 18042673DOI 10.1110/PS.073287008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3qc8 FAF1 crystal structure of faf1 ubx domain in complex with p97/vcp n domain reveals the conserved fcisp touch-turn motif of ubx domain suffering conformational change 2.2Å AUTH K.H.KIM,W.KANG,S.W.SUH,J.K.YANGTITL CRYSTAL STRUCTURE OF FAF1 UBX DOMAIN IN COMPLEX WITH P97/VCPTITL 2 N DOMAIN REVEALS A CONFORMATIONAL CHANGE IN THE CONSERVEDTITL 3 FCISP TOUCH-TURN […]
General Structure Information 1sgo GSKIP nmr structure of the human c14orf129 gene product, hspc210. northeast structural genomics target hr969. -1.0Å AUTH T.A.RAMELOT,J.R.CORT,R.XIAO,L.-Y.SHIH,L.-C.MA,AUTH 2 T.B.ACTON,G.T.MONTELIONE,M.A.KENNEDYTITL NMR STRUCTURE OF THE HUMAN C14ORF129 GENE PRODUCT,TITL 2 HSPC210. NORTHEAST STRUCTURAL GENOMICS TARGETTITL 3 HR969.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1rz4 EIF3K crystal structure of human eif3k 2.1Å AUTH Z.WEI,P.ZHANG,Z.ZHOU,Z.CHENG,M.WAN,W.GONGTITL CRYSTAL STRUCTURE OF HUMAN EIF3K, THE FIRST STRUCTURE OFTITL 2 EIF3 SUBUNITSREF J.BIOL.CHEM. V. 279 34983 2004REFN ISSN 0021-9258PMID 15180986DOI 10.1074/JBC.M405158200 Variant Set Distributions Mapped Variants
General Structure Information 4dxt SUN2 human sun2 (aa 522-717) 2.22Å AUTH B.A.SOSA,A.ROTHBALLER,U.KUTAY,T.U.SCHWARTZTITL LINC COMPLEXES FORM BY BINDING OF THREE KASH PEPTIDES TOTITL 2 DOMAIN INTERFACES OF TRIMERIC SUN PROTEINS.REF CELL(CAMBRIDGE,MASS.) V. 149 1035 2012REFN ISSN 0092-8674PMID 22632968DOI 10.1016/J.CELL.2012.03.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2oxc DDX20 human dead-box rna helicase ddx20, dead domain in complex with adp 1.3Å AUTH T.KARLBERG,D.OGG,C.H ARROWSMITH,H.BERGLUND,AUTH 2 R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,B.M.HALLBERG,AUTH 4 M.HAMMARSTROM,M.HOGBOM,I.JOHANSSON,T.KOTENYOVA,AUTH 5 L.LEHTIO,M.MOCHE,P.NORDLUND,T.NYMAN,C.PERSSON,AUTH 6 J.SAGEMARK,P.STENMARK,M.SUNDSTROM,A.G.THORSELL,AUTH 7 S.VAN DEN BERG,J.WEIGELT,L.HOLMBERG-SCHIAVONETITL HUMAN DEAD-BOX RNA HELICASE DDX20REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3uoa MALT1 crystal structure of the malt1 paracaspase (p21 form) 1.75Å AUTH J.W.YU,P.D.JEFFREY,J.Y.HA,X.YANG,Y.SHITITL CRYSTAL STRUCTURE OF THE MUCOSA-ASSOCIATED LYMPHOID TISSUETITL 2 LYMPHOMA TRANSLOCATION 1 (MALT1) PARACASPASE REGION.REF PROC.NATL.ACAD.SCI.USA V. 108 21004 2011REFN ISSN 0027-8424PMID 22158899DOI 10.1073/PNAS.1111708108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4cos ZMYND8 crystal structure of the phd-bromo-pwwp cassette of human prkcbp1 1.67Å AUTH P.FILIPPAKOPOULOSTITL CRYSTAL STRUCTURE OF THE PHD-BROMO-PWWP CASSETTE OF HUMANTITL 2 PRKCBP1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2m6n FBXO5 3d solution structure of emi1 (early mitotic inhibitor 1) -1.0Å AUTH J.J.FRYE,N.G.BROWN,G.PETZOLD,E.R.WATSON,C.R.GRACE,A.NOURSE,AUTH 2 M.A.JARVIS,R.W.KRIWACKI,J.M.PETERS,H.STARK,B.A.SCHULMANTITL ELECTRON MICROSCOPY STRUCTURE OF HUMAN APC/C(CDH1)-EMI1TITL 2 REVEALS MULTIMODAL MECHANISM OF E3 LIGASE SHUTDOWN.REF NAT.STRUCT.MOL.BIOL. V. 20 827 2013REFN ISSN 1545-9993PMID 23708605DOI 10.1038/NSMB.2593 Variant Set Distributions Mapped Variants