Assessment of Structural Intolerance and Durability
General Structure Information 4f9z ERP27 crystal structure of human erp27 2.2Å AUTH F.X.KOBER,W.KOELMEL,J.KUPER,J.DRECHSLER,C.MAIS,H.M.HERMANNS,AUTH 2 H.SCHINDELINTITL THE CRYSTAL STRUCTURE OF THE PROTEIN-DISULFIDE ISOMERASETITL 2 FAMILY MEMBER ERP27 PROVIDES INSIGHTS INTO ITS SUBSTRATETITL 3 BINDING CAPABILITIES.REF J.BIOL.CHEM. V. 288 2029 2013REFN ISSN 0021-9258PMID 23192347DOI 10.1074/JBC.M112.410522 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2vn8 RTN4IP1 crystal structure of human reticulon 4 interacting protein 1 in complex with nadph 2.1Å AUTH A.C.W.PIKE,K.GUO,J.ELKINS,E.UGOCHUKWU,A.K.ROOS,AUTH 2 P.FILIPPAKOPOULOS,F.VON DELFT,A.EDWARDS,C.H.ARROWSMITH,AUTH 3 J.WEIGELT,C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN RETICULON 4 INTERACTING PROTEINTITL 2 1 IN COMPLEX WITH NADPHREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2rkb SDSL serine dehydratase like-1 from human cancer cells 2.8Å AUTH T.YAMADA,J.KOMOTO,T.KASUYA,Y.TAKATA,H.OGAWA,H.MORI,AUTH 2 F.TAKUSAGAWATITL A CATALYTIC MECHANISM THAT EXPLAINS A LOW CATALYTIC ACTIVITYTITL 2 OF SERINE DEHYDRATASE LIKE-1 FROM HUMAN CANCER CELLS:TITL 3 CRYSTAL STRUCTURE AND SITE-DIRECTED MUTAGENESIS STUDIES.REF BIOCHIM.BIOPHYS.ACTA V.1780 809 2008REFN ISSN 0006-3002PMID 18342636DOI 10.1016/J.BBAGEN.2008.01.020 Variant Set Distributions Ripley’s K […]
General Structure Information 3ldz STAM crystal structure of human stam1 vhs domain in complex with ubiquitin 2.6Å AUTH X.REN,J.H.HURLEYTITL VHS DOMAINS OF ESCRT-0 COOPERATE IN HIGH-AVIDITYTITL 2 BINDING TO POLYUBIQUITINATED CARGO.REF EMBO J. V. 29 1045 2010REFN ISSN 0261-4189PMID 20150893DOI 10.1038/EMBOJ.2010.6 Variant Set Distributions Mapped Variants
General Structure Information 2bei SAT2 x-ray structure of thialysine n-acetyltransferase (ssat2) from homo sapiens 1.84Å AUTH B.W.HAN,C.A.BINGMAN,G.E.WESENBERG,G.N.PHILLIPSTITL CRYSTAL STRUCTURE OF HOMO SAPIENS THIALYSINETITL 2 NEPSILON-ACETYLTRANSFERASE (HSSSAT2) IN COMPLEXTITL 3 WITH ACETYL COENZYME A.REF PROTEINS V. 64 288 2006REFN ISSN 0887-3585PMID 16596569DOI 10.1002/PROT.20967 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1y02 RFFL crystal structure of a fyve-type domain from caspase regulator carp2 1.8Å AUTH M.D.TIBBETTS,E.N.SHIOZAKI,L.GU,E.R.MCDONALD,AUTH 2 W.S.EL-DEIRY,Y.SHITITL CRYSTAL STRUCTURE OF A FYVE-TYPE ZINC FINGERTITL 2 DOMAIN FROM THE CASPASE REGULATOR CARP2.REF STRUCTURE V. 12 2257 2004REFN ISSN 0969-2126PMID 15576038DOI 10.1016/J.STR.2004.10.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4hlq TBC1D20 crystal structure of human rab1b bound to gdp and bef3 in complex with the gap domain of tbc1d20 from homo sapiens 3.3Å AUTH K.GAVRILJUK,E.M.GAZDAG,A.ITZEN,C.KOTTING,R.S.GOODY,K.GERWERTTITL CATALYTIC MECHANISM OF A MAMMALIAN RAB-RABGAP COMPLEX INTITL 2 ATOMIC DETAIL.REF PROC.NATL.ACAD.SCI.USA V. 109 21348 2012REFN ISSN 0027-8424PMID 23236136DOI 10.1073/PNAS.1214431110 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2lgx FERMT2 nmr structure for kindle-2 n-terminus -1.0Å AUTH H.D.PERERA,Y.Q.MA,J.YANG,J.HIRBAWI,E.F.PLOW,J.QINTITL MEMBRANE BINDING OF THE N-TERMINAL UBIQUITIN-LIKE DOMAIN OFTITL 2 KINDLIN-2 IS CRUCIAL FOR ITS REGULATION OF INTEGRINTITL 3 ACTIVATION.REF STRUCTURE V. 19 1664 2011REFN ISSN 0969-2126PMID 22078565DOI 10.1016/J.STR.2011.08.012 Variant Set Distributions Mapped Variants
General Structure Information 1l2j ESR2 human estrogen receptor beta ligand-binding domain in complex with (r, r)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol 2.95Å AUTH A.K.SHIAU,D.BARSTAD,J.T.RADEK,M.J.MEYERS,K.W.NETTLES,AUTH 2 B.S.KATZENELLENBOGEN,J.A.KATZENELLENBOGEN,D.A.AGARD,AUTH 3 G.L.GREENETITL STRUCTURAL CHARACTERIZATION OF A SUBTYPE-SELECTIVE LIGANDTITL 2 REVEALS A NOVEL MODE OF ESTROGEN RECEPTOR ANTAGONISM.REF NAT.STRUCT.BIOL. V. 9 359 2002REFN ISSN 1072-8368PMID 11953755 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3d3k EDC3 crystal structure of human edc3p 2.2Å AUTH S.H.M.LING,C.J.DECKER,M.A.WALSH,M.SHE,R.PARKER,H.SONGTITL CRYSTAL STRUCTURE OF HUMAN EDC3 AND ITS FUNCTIONALTITL 2 IMPLICATIONSREF MOL.CELL.BIOL. V. 28 5965 2008REFN ISSN 0270-7306PMID 18678652DOI 10.1128/MCB.00761-08 Variant Set Distributions Mapped Variants