Assessment of Structural Intolerance and Durability
General Structure Information 1x5f NEO1 the solution structure of the first fibronectin type iii domain of human neogenin -1.0Å AUTH N.TOCHIO,A.SASAGAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL THE SOLUTION STRUCTURE OF THE FIRST FIBRONECTINTITL 2 TYPE III DOMAIN OF HUMAN NEOGENINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2pa1 PDLIM2 structure of the pdz domain of human pdlim2 bound to a c-terminal extension from human beta-tropomyosin 1.7Å AUTH J.UPPENBERG,L.SHRESTHA,J.ELKINS,N.BURGESS-BROWN,E.SALAH,AUTH 2 G.BUNKOCZI,E.PAPAGRIGORIOU,A.C.W.PIKE,A.P.TURNBULL,AUTH 3 E.UGOCHUKWU,C.UMEANO,F.VON DELFT,J.WEIGELT,C.H.ARROWSMITH,AUTH 4 A.EDWARDS,M.SUNDSTROM,D.A.DOYLETITL STRUCTURE OF THE PDZ DOMAIN OF HUMAN PDLIM2 BOUND TO ATITL 2 C-TERMINAL EXTENSION FROM HUMAN BETA-TROPOMYOSIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped […]
General Structure Information 3g9v IL22RA2 crystal structure of a soluble decoy receptor il-22bp bound to interleukin-22 2.76Å AUTH P.R.DE MOURA,L.WATANABE,L.BLEICHER,D.COLAU,AUTH 2 L.DUMOUTIER,M.M.LEMAIRE,J.-C.RENAULD,I.POLIKARPOVTITL CRYSTAL STRUCTURE OF A SOLUBLE DECOY RECEPTORTITL 2 IL-22BP BOUND TO INTERLEUKIN-22REF FEBS LETT. V. 583 1072 2009REFN ISSN 0014-5793PMID 19285080DOI 10.1016/J.FEBSLET.2009.03.006 Variant Set Distributions Mapped Variants
General Structure Information 2erx DIRAS2 crystal structure of diras2 in complex with gdp and inorganic phosphate 1.65Å AUTH E.PAPAGRIGORIOU,X.YANG,J.ELKINS,F.E.NIESEN,AUTH 2 N.BURGESS,E.SALAH,O.FEDOROV,L.J.BALL,F.VON DELFT,AUTH 3 M.SUNDSTROM,A.EDWARDS,C.ARROWSMITH,J.WEIGELT,AUTH 4 D.DOYLETITL CRYSTAL STRUCTURE OF DIRAS2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1xr0 FRS2 structural basis of snt ptb domain interactions with distinct neurotrophic receptors -1.0Å AUTH C.DHALLUIN,K.S.YAN,O.PLOTNIKOVA,K.W.LEE,L.ZENG,AUTH 2 M.KUTI,S.MUJTABA,M.P.GOLDFARB,M.-M.ZHOUTITL STRUCTURAL BASIS OF SNT PTB DOMAIN INTERACTIONSTITL 2 WITH DISTINCT NEUROTROPHIC RECEPTORSREF MOL.CELL V. 6 921 2000REFN ISSN 1097-2765PMID 11090629DOI 10.1016/S1097-2765(05)00087-0 Variant Set Distributions Mapped Variants
General Structure Information 4f52 GLMN structure of a glomulin-rbx1-cul1 complex 3.0Å AUTH D.M.DUDA,J.L.OLSZEWSKI,A.E.TRON,M.HAMMEL,L.J.LAMBERT,AUTH 2 M.B.WADDELL,T.MITTAG,J.A.DECAPRIO,B.A.SCHULMANTITL STRUCTURE OF A GLOMULIN-RBX1-CUL1 COMPLEX: INHIBITION OF ATITL 2 RING E3 LIGASE THROUGH MASKING OF ITS E2-BINDING SURFACE.REF MOL.CELL V. 47 371 2012REFN ISSN 1097-2765PMID 22748924DOI 10.1016/J.MOLCEL.2012.05.044 Variant Set Distributions Mapped Variants
General Structure Information 3ahr ERO1L inactive human ero1 3.07Å AUTH K.INABA,S.MASUI,H.IIDA,S.VAVASSORI,R.SITIA,M.SUZUKITITL CRYSTAL STRUCTURES OF HUMAN ERO1-ALPHA REVEAL THE MECHANISMSTITL 2 OF REGULATED AND TARGETED OXIDATION OF PDIREF EMBO J. V. 29 3330 2010REFN ISSN 0261-4189PMID 20834232DOI 10.1038/EMBOJ.2010.222 Variant Set Distributions Mapped Variants
General Structure Information 3ddt TRIM63 crystal structure of the b2 box from murf1 in dimeric state 1.9Å AUTH M.MROSEK,S.MEIER,Z.UCURUM-FOTIADIS,E.VON CASTELMUR,AUTH 2 E.HEDBOM,A.LUSTIG,S.GRZESIEK,D.LABEIT,S.LABEIT,AUTH 3 O.MAYANSTITL STRUCTURAL ANALYSIS OF B-BOX 2 FROM MURF1:TITL 2 IDENTIFICATION OF A NOVEL SELF-ASSOCIATION PATTERNTITL 3 IN A RING-LIKE FOLDREF BIOCHEMISTRY V. 47 10722 2008REFN ISSN 0006-2960PMID 18795805DOI 10.1021/BI800733Z Variant Set Distributions […]
General Structure Information 1qzu PPCDC crystal structure of human phosphopantothenoylcysteine decarboxylase 2.91Å AUTH N.MANOJ,S.E.EALICKTITL UNUSUAL SPACE-GROUP PSEUDOSYMMETRY IN CRYSTALS OF HUMANTITL 2 PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE.REF ACTA CRYSTALLOGR.,SECT.D V. 59 1762 2003REFN ISSN 0907-4449PMID 14501115DOI 10.1107/S0907444903016214 Variant Set Distributions Mapped Variants
General Structure Information 3bl7 DCPS synthetic gene encoded dcps bound to inhibitor dg156844 2.31Å AUTH J.SINGH,M.SALCIUS,S.W.LIU,B.L.STAKER,R.MISHRA,AUTH 2 J.THURMOND,G.MICHAUD,D.R.MATTOON,J.PRINTEN,AUTH 3 J.CHRISTENSEN,J.M.BJORNSSON,B.A.POLLOK,M.KILEDJIAN,AUTH 4 L.STEWART,J.JARECKI,M.E.GURNEYTITL DCPS AS A THERAPEUTIC TARGET FOR SPINAL MUSCULARTITL 2 ATROPHY.REF ACS CHEM.BIOL. V. 3 711 2008REFN ISSN 1554-8929PMID 18839960DOI 10.1021/CB800120T Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]