Assessment of Structural Intolerance and Durability
General Structure Information 1lo6 KLK6 human kallikrein 6 (hk6) active form with benzamidine inhibitor at 1.56 a resolution 1.56Å AUTH M.J.BERNETT,S.I.BLABER,I.A.SCARISBRICK,AUTH 2 P.DHANARAJAN,S.M.THOMPSON,M.BLABERTITL CRYSTAL STRUCTURE AND BIOCHEMICAL CHARACTERIZATIONTITL 2 OF HUMAN KALLIKREIN 6 REVEALS A TRYPSIN-LIKETITL 3 KALLIKREIN IS EXPRESSED IN THE CENTRAL NERVOUSTITL 4 SYSTEMREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2dme PHF3 solution structure of the tfiis domain ii of human phd finger protein 3 -1.0Å AUTH M.YONEYAMA,N.TOCHIO,S.KOSHIBA,S.WATABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE TFIIS DOMAIN II OF HUMANTITL 2 PHD FINGER PROTEIN 3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ut1 L3MBTL3 crystal structure of the 3-mbt repeat domain of l3mbtl3 2.05Å AUTH N.ZHONG,W.TEMPEL,A.K.WERNIMONT,S.GRASLUND,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,P.J.BROWNTITL CRYSTAL STRUCTURE OF THE 3-MBT REPEAT DOMAIN OF L3MBTL3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2iqj SMAP2 crystal structure of the gap domain of smap1l (loc64744) stromal membrane-associated protein 1-like 1.9Å AUTH Y.TONG,S.DIMOV,L.SHEN,W.TEMPEL,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL STRUCTURE OF THE GAP DOMAIN OF SMAP1L (LOC64744)TITL 2 STROMAL MEMBRANE-ASSOCIATED PROTEIN 1-LIKEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1ey2 HGD human homogentisate dioxygenase with fe(ii) 2.3Å AUTH G.P.TITUS,H.A.MUELLER,J.BURGNER,S.RODRIGUEZ DE CORDOBA,AUTH 2 M.A.PENALVA,D.E.TIMMTITL CRYSTAL STRUCTURE OF HUMAN HOMOGENTISATE DIOXYGENASE.REF NAT.STRUCT.BIOL. V. 7 542 2000REFN ISSN 1072-8368PMID 10876237DOI 10.1038/76756 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4f7h FERMT2 the crystal structure of kindlin-2 pleckstrin homology domain in free form 1.9Å AUTH Y.LIU,Y.ZHU,S.YE,R.ZHANGTITL CRYSTAL STRUCTURE OF KINDLIN-2 PH DOMAIN REVEALS ATITL 2 CONFORMATIONAL TRANSITION FOR ITS MEMBRANE ANCHORING ANDTITL 3 REGULATION OF INTEGRIN ACTIVATION.REF PROTEIN CELL V. 3 434 2012REFN ISSN 1674-800XPMID 22653426DOI 10.1007/S13238-012-2046-1 Variant Set Distributions Mapped Variants
General Structure Information 2i1n DLG3 crystal structure of the 1st pdz domain of human dlg3 1.85Å AUTH J.M.ELKINS,E.PAPAGRIGORIOU,G.BERRIDGE,X.YANG,C.PHILLIPS,AUTH 2 C.GILEADI,P.SAVITSKY,D.A.DOYLETITL STRUCTURE OF PICK1 AND OTHER PDZ DOMAINS OBTAINED WITH THETITL 2 HELP OF SELF-BINDING C-TERMINAL EXTENSIONS.REF PROTEIN SCI. V. 16 683 2007REFN ISSN 0961-8368PMID 17384233DOI 10.1110/PS.062657507 Variant Set Distributions Mapped Variants
General Structure Information 4juy RNF31 crystal structure of the pub domain of e3 ubiquitin ligase rnf31 2.4Å AUTH J.HU,A.DONG,Y.LI,A.WERNIMONT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,Y.TONGTITL CRYSTAL STRUCTURE OF THE PUB DOMAIN OF E3 UBIQUITIN LIGASETITL 2 RNF31REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2vx2 ECHDC3 crystal structure of human enoyl coenzyme a hydratase domain-containing protein 3 (echdc3) 2.3Å AUTH W.W.YUE,K.GUO,G.KOCHAN,E.PILKA,J.W.MURRAY,E.SALAH,R.COCKING,AUTH 2 Z.SUN,A.K.ROOS,A.C.W.PIKE,P.FILIPPAKOPOULOS,C.ARROWSMITH,AUTH 3 M.WIKSTROM,A.EDWARDS,C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN ENOYL COENZYME A HYDRATASETITL 2 DOMAIN-CONTAINING PROTEIN 3 (ECHDC3)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ytw HTRA1 solution structure of the pdz-domain of human protease htra 1 precursor -1.0Å AUTH A.K.GORONCY,K.SAITO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PDZ-DOMAIN OF HUMANTITL 2 PROTEASE HTRA 1 PRECURSORREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants