Assessment of Structural Intolerance and Durability
General Structure Information 1yzg ARL5B structure of human adp-ribosylation factor-like 8 2.0Å AUTH A.ATANASSOVA,J.CHOE,C.ARROWSMITH,A.EDWARDS,AUTH 2 M.SUNDSTROM,A.BOCHKAREV,H.PARKTITL STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR-LIKE 8REF TO BE PUBLISHED 2005REFN Variant Set Distributions Mapped Variants
General Structure Information 2kje CREBBP nmr structure of cbp taz2 and adenoviral e1a complex -1.0Å AUTH J.C.FERREON,M.A.MARTINEZ-YAMOUT,H.J.DYSON,AUTH 2 P.E.WRIGHTTITL STRUCTURAL BASIS FOR SUBVERSION OF CELLULAR CONTROLTITL 2 MECHANISMS BY THE ADENOVIRAL E1A ONCOPROTEIN.REF PROC.NATL.ACAD.SCI.USA V. 106 13260 2009REFN ISSN 0027-8424PMID 19651603DOI 10.1073/PNAS.0906770106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1zd9 ARL8A structure of human adp-ribosylation factor-like 10b 1.7Å AUTH A.ATANASSOVA,J.CHOE,C.ARROWSMITH,A.EDWARDS,AUTH 2 M.SUNDSTROM,A.BOCHKAREV,H.PARKTITL STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR-LIKE 10BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3b13 DOCK2 crystal structure of the dhr-2 domain of dock2 in complex with rac1 (t17n mutant) 3.01Å AUTH K.HANAWA-SUETSUGU,M.KUKIMOTO-NIINO,C.MISHIMA-TSUMAGARI,AUTH 2 R.AKASAKA,N.OHSAWA,S.SEKINE,T.ITO,N.TOCHIO,S.KOSHIBA,AUTH 3 T.KIGAWA,T.TERADA,M.SHIROUZU,A.NISHIKIMI,T.URUNO,T.KATAKAI,AUTH 4 T.KINASHI,D.KOHDA,Y.FUKUI,S.YOKOYAMATITL STRUCTURAL BASIS FOR MUTUAL RELIEF OF THE RAC GUANINETITL 2 NUCLEOTIDE EXCHANGE FACTOR DOCK2 AND ITS PARTNER ELMO1 FROMTITL 3 THEIR AUTOINHIBITED FORMS.REF PROC.NATL.ACAD.SCI.USA V. 109 3305 […]
General Structure Information 3tht ALKBH8 crystal structure and rna binding properties of the rrm/alkb domains in human abh8, an enzyme catalyzing trna hypermodification, northeast structural genomics consortium target hr5601b 3.01Å AUTH C.PASTORE,I.TOPALIDOU,F.FOROUHAR,A.C.YAN,M.LEVY,J.F.HUNTTITL CRYSTAL STRUCTURE AND RNA BINDING PROPERTIES OF THE RNATITL 2 RECOGNITION MOTIF (RRM) AND ALKB DOMAINS IN HUMAN ALKBTITL 3 HOMOLOG 8 (ABH8), […]
General Structure Information 3o2q SYMPK crystal structure of the human symplekin-ssu72-ctd phosphopeptide complex 2.4Å AUTH K.XIANG,T.NAGAIKE,S.XIANG,T.KILIC,M.M.BEH,J.L.MANLEY,L.TONGTITL CRYSTAL STRUCTURE OF THE HUMAN SYMPLEKIN-SSU72-CTDTITL 2 PHOSPHOPEPTIDE COMPLEX.REF NATURE V. 467 729 2010REFN ISSN 0028-0836PMID 20861839DOI 10.1038/NATURE09391 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2dm3 PALLD solution structure of the second ig domain of human palladin -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND IG DOMAIN OFTITL 2 HUMAN PALLADINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kvw DYRK2 crystal structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (dyrk2) in complex with an indirubin ligand 2.28Å AUTH P.FILIPPAKOPOULOS,V.MYRIANTHOPOULOS,M.KRITSANIDA,P.MAGIATIS,AUTH 2 A.L.SKALTSOUNIS,M.SOUNDARARAJAN,T.KROJER,O.GILEADI,E.HAPKA,AUTH 3 O.FEDOROV,G.BERRIDGE,J.WANG,L.SHRESTHA,M.VOLLMAR,AUTH 4 F.VON DELFT,C.H.ARROWSMITH,A.EDWARDS,J.WEIGELT,C.BOUNTRA,AUTH 5 E.MIKROS,S.KNAPPTITL CRYSTAL STRUCTURE OF DUAL-SPECIFICITY TYROSINETITL 2 PHOSPHORYLATION REGULATED KINASE 2 (DYRK2) IN COMPLEX WITHTITL 3 AN INDIRUBIN LIGANDREF TO BE PUBLISHEDREFN Variant […]
General Structure Information 2id5 LINGO1 crystal structure of the lingo-1 ectodomain 2.7Å AUTH L.MOSYAK,A.WOOD,B.DWYER,M.BUDDHA,M.JOHNSON,A.AULABAUGH,AUTH 2 X.ZHONG,E.PRESMAN,S.BENARD,K.KELLEHER,J.WILHELM,M.L.STAHL,AUTH 3 R.KRIZ,Y.GAO,Z.CAO,H.P.LING,M.N.PANGALOS,F.S.WALSH,AUTH 4 W.S.SOMERSTITL THE STRUCTURE OF THE LINGO-1 ECTODOMAIN, A MODULE IMPLICATEDTITL 2 IN CENTRAL NERVOUS SYSTEM REPAIR INHIBITION.REF J.BIOL.CHEM. V. 281 36378 2006REFN ISSN 0021-9258PMID 17005555DOI 10.1074/JBC.M607314200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2xnk TOPBP1 structure and function of the rad9-binding region of the dna damage checkpoint adaptor topbp1 2.6Å AUTH M.RAPPAS,A.W.OLIVER,L.H.PEARLTITL STRUCTURE AND FUNCTION OF THE RAD9-BINDING REGION OF THETITL 2 DNA-DAMAGE CHECKPOINT ADAPTOR TOPBP1.REF NUCLEIC ACIDS RES. V. 39 313 2011REFN ISSN 0305-1048PMID 20724438DOI 10.1093/NAR/GKQ743 Variant Set Distributions Mapped Variants