General Structure Information
| PDB ID | 2id5 |
| HGNC Gene Label(s) | LINGO1 |
| Structure Name | crystal structure of the lingo-1 ectodomain |
| Resolution | 2.7Å |
| Reference | AUTH L.MOSYAK,A.WOOD,B.DWYER,M.BUDDHA,M.JOHNSON,A.AULABAUGH,AUTH 2 X.ZHONG,E.PRESMAN,S.BENARD,K.KELLEHER,J.WILHELM,M.L.STAHL,AUTH 3 R.KRIZ,Y.GAO,Z.CAO,H.P.LING,M.N.PANGALOS,F.S.WALSH,AUTH 4 W.S.SOMERSTITL THE STRUCTURE OF THE LINGO-1 ECTODOMAIN, A MODULE IMPLICATEDTITL 2 IN CENTRAL NERVOUS SYSTEM REPAIR INHIBITION.REF J.BIOL.CHEM. V. 281 36378 2006REFN ISSN 0021-9258PMID 17005555DOI 10.1074/JBC.M607314200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 471 |
| Number Of SNVs | 102 |
| Number Of Permutations | 42024 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.124 |
| p-value | 0.002 |
COSMIC
| Number Of Residues | 471 |
| Number Of SNVs | 12 |
| Number Of Permutations | 21265 |
| Optimal Distance Threshold | 35.0 |
| K Statistic | 0.303 |
| p-value | 0.18 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 102 |
| Number Of COSMIC SNVs | 10 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | -0.035 |
| p-value | 0.966 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
