Assessment of Structural Intolerance and Durability
General Structure Information 4ifp NLRP1 x-ray crystal structure of human nlrp1 card domain 1.99Å AUTH T.JIN,J.CURRY,P.SMITH,J.JIANG,T.S.XIAOTITL STRUCTURE OF THE NLRP1 CASPASE RECRUITMENT DOMAIN SUGGESTSTITL 2 POTENTIAL MECHANISMS FOR ITS ASSOCIATION WITH PROCASPASE-1.REF PROTEINS V. 81 1266 2013REFN ISSN 0887-3585PMID 23508996DOI 10.1002/PROT.24287 Variant Set Distributions Mapped Variants
General Structure Information 2cn1 NT5C3A crystal structure of human cytosolic 5-nucleotidase iii ( nt5c3)(casp target) 2.67Å AUTH K.WALLDEN,P.STENMARK,T.NYMAN,S.FLODIN,S.GRASLUND,P.LOPPNAU,AUTH 2 V.BIANCHI,P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC 5-NUCLEOTIDASE II:TITL 2 INSIGHTS INTO ALLOSTERIC REGULATION AND SUBSTRATETITL 3 RECOGNITION.REF J.BIOL.CHEM. V. 282 17828 2007REFN ISSN 0021-9258PMID 17405878DOI 10.1074/JBC.M700917200 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ihw AGAP3 crystal structure of the ras-like domain of centg3 1.92Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,Y.LI,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RAS-LIKE DOMAIN OF CENTG3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4im6 NLRP1 lrr domain from human nlrp1 1.65Å Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2rep KIFC1 crystal structure of the motor domain of human kinesin family member c1 2.6Å AUTH H.ZHU,W.TEMPEL,H.HE,Y.SHEN,J.WANG,G.BROTHERS,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF HUMAN KINESINTITL 2 FAMILY MEMBER C1.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1yhn RILP structure basis of rilp recruitment by rab7 3.0Å AUTH M.WU,T.WANG,E.LOH,W.HONG,H.SONGTITL STRUCTURAL BASIS FOR RECRUITMENT OF RILP BY SMALL GTPASETITL 2 RAB7.REF EMBO J. V. 24 1491 2005REFN ISSN 0261-4189PMID 15933719DOI 10.1038/SJ.EMBOJ.7600643 Variant Set Distributions Mapped Variants
General Structure Information 1v88 OSBPL8 solution structure of the pleckstrin homology domain of oxysterol-binding protein-related protein 8 (kiaa1451 protein) -1.0Å AUTH H.LI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PLECKSTRIN HOMOLOGYTITL 2 DOMAIN OF OXYSTEROL-BINDING PROTEIN-RELATEDTITL 3 PROTEIN 8 (KIAA1451 PROTEIN)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2yud YTHDC1 solution structure of the yth domain in yth domain- containing protein 1 (putative splicing factor yt521) -1.0Å AUTH F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TARADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE YTH DOMAIN IN YTHTITL 2 DOMAIN-CONTAINING PROTEIN 1 (PUTATIVE SPLICINGTITL 3 FACTOR YT521)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1dgv CIB1 homology-based model of apo cib (calcium-and integrin- binding protein) -1.0Å AUTH P.M.HWANG,H.J.VOGELTITL STRUCTURES OF THE PLATELET CALCIUM- ANDTITL 2 INTEGRIN-BINDING PROTEIN AND THE ALPHAIIB-INTEGRINTITL 3 CYTOPLASMIC DOMAIN SUGGEST A MECHANISM FORTITL 4 CALCIUM-REGULATED RECOGNITION; HOMOLOGY MODELLINGTITL 5 AND NMR STUDIES.REF J.MOL.RECOG. V. 13 83 2000REFN ISSN 0952-3499PMID 10822252DOI 10.1002/(SICI)1099-1352(200003/04)13:23.3.CO;2-1 Variant […]
General Structure Information 2wmn DOCK9 structure of the complex between dock9 and cdc42-gdp. 2.39Å AUTH J.YANG,Z.ZHANG,S.M.ROE,C.J.MARSHALL,D.BARFORDTITL ACTIVATION OF RHO GTPASES BY DOCK EXCHANGE FACTORSTITL 2 IS MEDIATED BY A NUCLEOTIDE SENSOR.REF SCIENCE V. 325 1398 2009REFN ISSN 0036-8075PMID 19745154DOI 10.1126/SCIENCE.1174468 Variant Set Distributions Mapped Variants