Assessment of Structural Intolerance and Durability
General Structure Information 3qrf FOXP3 structure of a domain-swapped foxp3 dimer 2.8Å AUTH H.S.BANDUKWALA,Y.WU,M.FEUERER,Y.CHEN,B.BARBOZA,S.GHOSH,AUTH 2 J.C.STROUD,C.BENOIST,D.MATHIS,A.RAO,L.CHENTITL STRUCTURE OF A DOMAIN-SWAPPED FOXP3 DIMER ON DNA AND ITSTITL 2 FUNCTION IN REGULATORY T CELLS.REF IMMUNITY V. 34 479 2011REFN ISSN 1074-7613PMID 21458306DOI 10.1016/J.IMMUNI.2011.02.017 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4n1d NODAL nodal/bmp2 chimera nb250 1.91Å AUTH L.ESQUIVIES,A.BLACKLER,M.PERAN,C.RODRIGUEZ-ESTEBAN,AUTH 2 J.C.IZPISUA BELMONTE,E.BOOKER,P.C.GRAY,C.AHN,W.KWIATKOWSKI,AUTH 3 S.CHOETITL DESIGNER NODAL/BMP2 CHIMERAS MIMIC NODAL SIGNALING, PROMOTETITL 2 CHONDROGENESIS, AND REVEAL A BMP2-LIKE STRUCTURE.REF J.BIOL.CHEM. V. 289 1788 2014REFN ISSN 0021-9258PMID 24311780DOI 10.1074/JBC.M113.529180 Variant Set Distributions Mapped Variants
General Structure Information 2ovj RACGAP1 the crystal structure of the human rac gtpase activating protein 1 (racgap1) mgcracgap. 1.49Å AUTH L.SHRESTHA,E.PAPAGRIGORIOU,M.SOUNDARARAJAN,J.ELKINS,AUTH 2 C.JOHANSSON,F.VON DELFT,A.C.W.PIKE,N.BURGESS,A.TURNBULL,AUTH 3 J.DEBRECZENI,F.GORREC,C.UMEANO,A.EDWARDS,C.H.ARROWSMITH,AUTH 4 J.WEIGELT,M.SUNDSTROM,D.A.DOYLETITL THE CRYSTAL STRUCTURE OF THE HUMAN RAC GTPASE ACTIVATINGTITL 2 PROTEIN 1 (RACGAP1) MGCRACGAP.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ew3 SH3GL3 solution structure of the sh3 domain of human sh3gl3 -1.0Å AUTH Y.G.GAO,X.Z.YAN,H.Y.HUTITL STRUCTURAL BASIS FOR THE BINDING SPECIFICITIES OFTITL 2 HUNTINGTIN PROLINE-RICH REGION WITH SH3 AND WWTITL 3 DOMAINSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4apc NEK1 crystal structure of human nima-related kinase 1 (nek1) 2.1Å AUTH J.M.ELKINS,T.D.M.HANCHUK,D.V.LOVATO,F.L.BASEI,G.V.MEIRELLES,AUTH 2 J.KOBARG,M.SZKLARZ,M.VOLLMAR,P.MAHAJAN,P.RELLOS,Y.ZHANG,AUTH 3 T.KROJER,A.C.W.PIKE,C.BOUNTRA,C.ARROWSMITH,A.EDWARDS,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN NIMA-RELATED KINASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2b6f SRXN1 solution structure of human sulfiredoxin (srx) -1.0Å AUTH D.-Y.LEE,S.J.PARK,W.JEONG,H.J.SUNG,T.OHO,X.WU,AUTH 2 S.G.RHEE,J.M.GRUSCHUSTITL MUTAGENESIS AND MODELING OF THE PEROXIREDOXINTITL 2 (PRX) COMPLEX WITH THE NMR STRUCTURE OF ATP-BOUNDTITL 3 HUMAN SULFIREDOXIN IMPLICATE ASPARTATE 187 OF PRXTITL 4 I AS THE CATALYTIC RESIDUE IN ATP HYDROLYSISREF BIOCHEMISTRY V. 45 15301 2006REFN ISSN 0006-2960PMID […]
General Structure Information 1uw4 UPF3B the structural basis of the interaction between nonsense mediated decay factors upf2 and upf3 1.95Å AUTH J.KADLEC,E.IZAURRALDE,S.CUSACKTITL THE STRUCTURAL BASIS FOR THE INTERACTION BETWEENTITL 2 NONSENSE-MEDIATED MRNA DECAY FACTORS UPF2 AND UPF3REF NAT.STRUCT.MOL.BIOL. V. 11 330 2004REFN ISSN 1545-9993PMID 15004547DOI 10.1038/NSMB741 Variant Set Distributions Mapped Variants
General Structure Information 4gl2 IFIH1 structural basis for dsrna duplex backbone recognition by mda5 3.56Å AUTH B.WU,A.PEISLEY,C.RICHARDS,H.YAO,X.ZENG,C.LIN,F.CHU,T.WALZ,AUTH 2 S.HURTITL STRUCTURAL BASIS FOR DSRNA RECOGNITION, FILAMENT FORMATION,TITL 2 AND ANTIVIRAL SIGNAL ACTIVATION BY MDA5.REF CELL(CAMBRIDGE,MASS.) V. 152 276 2013REFN ISSN 0092-8674PMID 23273991DOI 10.1016/J.CELL.2012.11.048 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3rqf PDCD10 cerebral cavernous malformation 3 (ccm3) in complex with paxillin ld2 2.7Å AUTH X.LI,W.JI,R.ZHANG,E.FOLTA-STOGNIEW,W.MIN,T.J.BOGGONTITL MOLECULAR RECOGNITION OF LEUCINE-ASPARTATE REPEAT (LD)TITL 2 MOTIFS BY THE FOCAL ADHESION TARGETING HOMOLOGY DOMAIN OFTITL 3 CEREBRAL CAVERNOUS MALFORMATION 3 (CCM3).REF J.BIOL.CHEM. V. 286 26138 2011REFN ISSN 0021-9258PMID 21632544DOI 10.1074/JBC.M110.211250 Variant Set Distributions Mapped Variants
General Structure Information 4h4f CTRC crystal structure of human chymotrypsin c (ctrc) bound to inhibitor eglin c from hirudo medicinalis 1.9Å AUTH J.BATRA,A.SZABO,T.R.CAULFIELD,A.S.SOARES,M.SAHIN-TOTH,AUTH 2 E.S.RADISKYTITL LONG-RANGE ELECTROSTATIC COMPLEMENTARITY GOVERNS SUBSTRATETITL 2 RECOGNITION BY HUMAN CHYMOTRYPSIN C, A KEY REGULATOR OFTITL 3 DIGESTIVE ENZYME ACTIVATION.REF J.BIOL.CHEM. V. 288 9848 2013REFN ISSN 0021-9258PMID 23430245DOI 10.1074/JBC.M113.457382 Variant Set […]