Assessment of Structural Intolerance and Durability
General Structure Information 3sd4 PHF20 crystal structure of the first tudor domain of human phf20 1.93Å AUTH G.CUI,S.PARK,A.I.BADEAUX,D.KIM,J.LEE,J.R.THOMPSON,F.YAN,AUTH 2 S.KANEKO,Z.YUAN,M.V.BOTUYAN,M.T.BEDFORD,J.Q.CHENG,G.MERTITL PHF20 IS AN EFFECTOR PROTEIN OF P53 DOUBLE LYSINETITL 2 METHYLATION THAT STABILIZES AND ACTIVATES P53.REF NAT.STRUCT.MOL.BIOL. V. 19 916 2012REFN ISSN 1545-9993PMID 22864287DOI 10.1038/NSMB.2353 Variant Set Distributions Mapped Variants
General Structure Information 2kk0 ARID3A solution structure of dead ringer-like protein 1 (at-rich interactive domain-containing protein 3a) from homo sapiens, northeast structural genomics consortium (nesg) target hr4394c -1.0Å AUTH G.LIU,Y.J.HUANG,R.XIAO,D.WANG,T.B.ACTON,G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF THE ARID DOMAIN OF HUMAN AT-RICHTITL 2 INTERACTIVE DOMAIN-CONTAINING PROTEIN 3A: A HUMAN CANCERTITL 3 PROTEIN INTERACTION NETWORK TARGET.REF PROTEINS V. […]
General Structure Information 3bpu MAGI1 crystal structure of the 3rd pdz domain of human membrane associated guanylate kinase, c677s and c709s double mutant 1.6Å AUTH E.S.PILKA,V.HOZJAN,C.COOPER,A.C.W.PIKE,J.ELKINS,D.A.DOYLE,AUTH 2 F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE 3RD PDZ DOMAIN OF HUMAN MEMBRANETITL 2 ASSOCIATED GUANYLATE KINASE, C677S AND C709S DOUBLE MUTANT.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped […]
General Structure Information 2heh KIF2C crystal structure of the kif2c motor domain (casp target) 2.15Å AUTH J.WANG,Y.SHEN,W.TEMPEL,R.LANDRY,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE KIF2C MOTOR DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2coa PRKD2 solution structure of the ph domain of protein kinase c, d2 type from human -1.0Å AUTH H.LI,K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF PROTEINTITL 2 KINASE C, D2 TYPE FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3tfy NAA50 naa50p amino-terminal acetyltransferase bound to substrate peptide fragment and coa 2.75Å AUTH G.LISZCZAK,T.ARNESEN,R.MARMORSTEINTITL STRUCTURE OF A TERNARY NAA50P (NAT5/SAN) N-TERMINALTITL 2 ACETYLTRANSFERASE COMPLEX REVEALS THE MOLECULAR BASIS FORTITL 3 SUBSTRATE-SPECIFIC ACETYLATION.REF J.BIOL.CHEM. V. 286 37002 2011REFN ISSN 0021-9258PMID 21900231DOI 10.1074/JBC.M111.282863 Variant Set Distributions Mapped Variants
General Structure Information 4h5s CADM1 complex structure of necl-2 and crtam 1.7Å AUTH S.ZHANG,G.LU,J.QI,Y.LI,Z.ZHANG,B.ZHANG,Z.FAN,J.YAN,G.F.GAOTITL COMPETITION OF CELL ADHESION AND IMMUNE RECOGNITION:TITL 2 INSIGHTS INTO THE INTERACTION BETWEEN CRTAM AND NECTIN-LIKETITL 3 2REF STRUCTURE V. 21 2013REFN ISSN 0969-2126PMID 23871486DOI 10.1016/J.STR.2013.06.006 Variant Set Distributions Mapped Variants
General Structure Information 2h57 ARL6 crystal structure of human adp-ribosylation factor-like 6 2.0Å AUTH J.WANG,Y.SHEN,W.TEMPEL,R.LANDRY,J.LEW,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN ADP-RIBOSYLATIONTITL 2 FACTOR-LIKE 6 (CASP TARGET)REF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lj8 DUSP9 crystal structure of mkp-4 2.7Å AUTH D.G.JEONG,T.S.YOON,S.-K.JUNG,B.C.PARK,H.S.PARK,S.E.RYU,AUTH 2 S.J.KIMTITL EXPLORING BINDING SITES OTHER THAN THE CATALYTIC CORE IN THETITL 2 CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MKP-4REF ACTA CRYSTALLOGR.,SECT.D V. 67 25 2011REFN ISSN 0907-4449PMID 21206059DOI 10.1107/S0907444910042381 Variant Set Distributions Mapped Variants
General Structure Information 1zd1 SULT4A1 human sulfortransferase sult4a1 2.24Å AUTH A.ALLALI-HASSANI,P.W.PAN,L.DOMBROVSKI,R.NAJMANOVICH,AUTH 2 W.TEMPEL,A.DONG,P.LOPPNAU,F.MARTIN,J.THORNTON,J.THONTON,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOV,M.VEDADI,AUTH 4 C.H.ARROWSMITHTITL STRUCTURAL AND CHEMICAL PROFILING OF THE HUMAN CYTOSOLICTITL 2 SULFOTRANSFERASES.REF PLOS BIOL. V. 5 E97 2007REFN ISSN 1544-9173PMID 17425406DOI 10.1371/JOURNAL.PBIO.0050097 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants