Assessment of Structural Intolerance and Durability
General Structure Information 2hei RAB5B crystal structure of human rab5b in complex with gdp 1.55Å AUTH B.HONG,L.SHEN,J.WANG,W.TEMPEL,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB5B IN COMPLEX WITHTITL 2 GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3v31 HDAC4 crystal structure of the peptide bound complex of the ankyrin repeat domains of human ankra2 1.57Å AUTH C.XU,J.JIN,C.BIAN,R.LAM,R.TIAN,R.WEIST,L.YOU,J.NIE,AUTH 2 A.BOCHKAREV,W.TEMPEL,C.S.TAN,G.A.WASNEY,M.VEDADI,G.D.GISH,AUTH 3 C.H.ARROWSMITH,T.PAWSON,X.J.YANG,J.MINTITL SEQUENCE-SPECIFIC RECOGNITION OF A PXLPXI/L MOTIF BY ANTITL 2 ANKYRIN REPEAT TUMBLER LOCK.REF SCI.SIGNAL. V. 5 RA39 2012REFN ESSN 1937-9145PMID 22649097DOI 10.1126/SCISIGNAL.2002979 Variant Set Distributions Mapped Variants
General Structure Information 2obv MAT1A crystal structure of the human s-adenosylmethionine synthetase 1 in complex with the product 2.05Å AUTH E.S.PILKA,N.SHAFQAT,K.L.KAVANAGH,C.COOPER,V.HOZJAN,AUTH 2 A.TURNBULL,F.VON DELFT,C.H.ARROWSMITH,A.EDWARDS,J.WEIGELT,AUTH 3 M.SUNDSTROM,U.OPPERMANN,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE HUMAN S-ADENOSYLMETHIONINETITL 2 SYNTHETASE 1 IN COMPLEX WITH THE PRODUCT.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1esr CCL8 crystal structure of human monocyte chemotactic protein-2 2.0Å AUTH J.BLASZCZYK,E.V.COILLIE,P.PROOST,J.V.DAMME,AUTH 2 G.OPDENAKKER,G.D.BUJACZ,J.M.WANG,X.JITITL COMPLETE CRYSTAL STRUCTURE OF MONOCYTE CHEMOTACTICTITL 2 PROTEIN-2, A CC CHEMOKINE THAT INTERACTS WITHTITL 3 MULTIPLE RECEPTORS.REF BIOCHEMISTRY V. 39 14075 2000REFN ISSN 0006-2960PMID 11087354DOI 10.1021/BI0009340 Variant Set Distributions Mapped Variants
General Structure Information 3mmy RAE1 structural and functional analysis of the interaction between the nucleoporin nup98 and the mrna export factor rae1 1.65Å AUTH Y.REN,H.S.SEO,G.BLOBEL,A.HOELZTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE INTERACTIONTITL 2 BETWEEN THE NUCLEOPORIN NUP98 AND THE MRNA EXPORT FACTORTITL 3 RAE1.REF PROC.NATL.ACAD.SCI.USA V. 107 10406 2010REFN ISSN 0027-8424PMID 20498086DOI 10.1073/PNAS.1005389107 Variant Set […]
General Structure Information 4f8q BTN3A2 crystal structure of the human btn3a2 ectodomain 2.38Å AUTH A.PALAKODETI,A.SANDSTROM,L.SUNDARESAN,C.HARLY,S.NEDELLEC,AUTH 2 D.OLIVE,E.SCOTET,M.BONNEVILLE,E.J.ADAMSTITL THE MOLECULAR BASIS FOR MODULATION OF HUMANTITL 2 V(GAMMA)9V(DELTA)2 T CELL RESPONSES BY CD277/BUTYROPHILIN-3TITL 3 (BTN3A)-SPECIFIC ANTIBODIESREF J.BIOL.CHEM. V. 287 32780 2012REFN ISSN 0021-9258PMID 22846996DOI 10.1074/JBC.M112.384354 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1q1u FGF12 crystal structure of human fhf1b (fgf12b) 1.7Å AUTH S.K.OLSEN,M.GARBI,N.ZAMPIERI,A.V.ELISEENKOVA,AUTH 2 D.M.ORNITZ,M.GOLDFARB,M.MOHAMMADITITL FIBROBLAST GROWTH FACTOR (FGF) HOMOLOGOUS FACTORSTITL 2 SHARE STRUCTURAL BUT NOT FUNCTIONAL HOMOLOGY WITHTITL 3 FGFSREF J.BIOL.CHEM. V. 278 34226 2003REFN ISSN 0021-9258PMID 12815063DOI 10.1074/JBC.M303183200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1y8x UBE2M structural basis for recruitment of ubc12 by an e2-binding domain in nedd8s e1 2.4Å AUTH D.T.HUANG,A.PAYDAR,M.ZHUANG,M.B.WADDELL,J.M.HOLTON,AUTH 2 B.A.SCHULMANTITL STRUCTURAL BASIS FOR RECRUITMENT OF UBC12 BY AN E2TITL 2 BINDING DOMAIN IN NEDD8S E1.REF MOL.CELL V. 17 341 2005REFN ISSN 1097-2765PMID 15694336DOI 10.1016/J.MOLCEL.2004.12.020 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2yuz MYBPC1 solution structure of 4th immunoglobulin domain of slow type myosin-binding protein c -1.0Å AUTH T.N.NIRAULA,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF 4TH IMMUNOGLOBULIN DOMAIN OFTITL 2 SLOW TYPE MYOSIN-BINDING PROTEIN CREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1i3d HBG1 human carbonmonoxy hemoglobin barts (gamma4) 1.7Å AUTH R.D.KIDD,H.M.BAKER,A.J.MATHEWS,T.BRITTAIN,E.N.BAKERTITL OLIGOMERIZATION AND LIGAND BINDING IN ATITL 2 HOMOTETRAMERIC HEMOGLOBIN: TWO HIGH-RESOLUTIONTITL 3 CRYSTAL STRUCTURES OF HEMOGLOBIN BARTSTITL 4 (GAMMA(4)), A MARKER FOR ALPHA-THALASSEMIA.REF PROTEIN SCI. V. 10 1739 2001REFN ISSN 0961-8368PMID 11514664DOI 10.1110/PS.11701 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]