Assessment of Structural Intolerance and Durability
General Structure Information 1ljm RUNX1 dna recognition is mediated by conformational transition and by dna bending 2.5Å AUTH D.BARTFELD,L.SHIMON,G.COUTURE,D.RABINOVICH,AUTH 2 F.FROLOW,D.LEVANON,Y.GRONER,Z.SHAKKEDTITL DNA RECOGNITION BY THE RUNX1 TRANSCRIPTION FACTORTITL 2 IS MEDIATED BY AN ALLOSTERIC TRANSITION IN THETITL 3 RUNT DOMAIN AND BY DNA BENDING.REF STRUCTURE V. 10 1395REFN ISSN 0969-2126PMID 12377125DOI 10.1016/S0969-2126(02)00853-5 Variant Set Distributions […]
General Structure Information 3wiy MCL1 crystal structure of mcl-1 in complex with compound 10 2.15Å AUTH Y.TANAKA,K.AIKAWA,G.NISHIDA,M.HOMMA,S.SOGABE,S.IGAKI,AUTH 2 Y.HAYANO,T.SAMESHIMA,I.MIYAHISA,T.KAWAMOTO,M.TAWADA,Y.IMAI,AUTH 3 M.INAZUKA,N.CHO,Y.IMAEDA,T.ISHIKAWATITL DISCOVERY OF POTENT MCL-1/BCL-XL DUAL INHIBITORS BY USING ATITL 2 HYBRIDIZATION STRATEGY BASED ON STRUCTURAL ANALYSIS OFTITL 3 TARGET PROTEINS.REF J.MED.CHEM. V. 56 9635 2013REFN ISSN 0022-2623PMID 24215352DOI 10.1021/JM401170C Variant Set Distributions Mapped Variants
General Structure Information 3jui EIF2B5 crystal structure of the c-terminal domain of human translation initiation factor eif2b epsilon subunit 2.0Å AUTH J.WEI,H.XU,C.ZHANG,M.WANG,F.GAO,W.GONGTITL CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMANTITL 2 TRANSLATION INITIATION FACTOR EIF2B EPSILON SUBUNITREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2nn6 EXOSC9 structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40 3.35Å AUTH Q.LIU,J.C.GREIMANN,C.D.LIMATITL RECONSTITUTION, ACTIVITIES, AND STRUCTURE OF THETITL 2 EUKARYOTIC RNA EXOSOME.REF CELL(CAMBRIDGE,MASS.) V. 127 1223 2006REFN ISSN 0092-8674PMID 17174896DOI 10.1016/J.CELL.2006.10.037 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1e8i CD69 human cd69 – tetragonal form 1.95Å AUTH A.S.LLERA,F.VIEDMA,F.SANCHEZ-MADRID,J.TORMOTITL CRYSTAL STRUCTURE OF THE C-TYPE LECTIN-LIKE DOMAINTITL 2 FROM THE HUMAN HEMATOPOIETIC CELL RECEPTOR CD69REF J.BIOL.CHEM. V. 276 7312 2001REFN ISSN 0021-9258PMID 11036086DOI 10.1074/JBC.M008573200 Variant Set Distributions Mapped Variants
General Structure Information 4bd7 BAX bax domain swapped dimer induced by octylmaltoside 2.9Å AUTH P.E.CZABOTAR,D.WESTPHAL,G.DEWSON,S.MA,C.HOCKINGS,AUTH 2 W.D.FAIRLIE,E.F.LEE,S.YAO,A.Y.ROBIN,B.J.SMITH,D.C.HUANG,AUTH 3 R.M.KLUCK,J.M.ADAMS,P.M.COLMANTITL BAX CRYSTAL STRUCTURES REVEAL HOW BH3 DOMAINS ACTIVATE BAXTITL 2 AND NUCLEATE ITS OLIGOMERIZATION TO INDUCE APOPTOSIS.REF CELL(CAMBRIDGE,MASS.) V. 152 519 2013REFN ISSN 0092-8674PMID 23374347DOI 10.1016/J.CELL.2012.12.031 Variant Set Distributions Mapped Variants
General Structure Information 1zdt NR5A1 the crystal structure of human steroidogenic factor-1 2.1Å AUTH W.WANG,C.ZHANG,A.MARIMUTHU,H.I.KRUPKA,M.TABRIZIZAD,AUTH 2 R.SHELLOE,U.MEHRA,K.ENG,H.NGUYEN,C.SETTACHATGUL,B.POWELL,AUTH 3 M.V.MILBURN,B.L.WESTTITL THE CRYSTAL STRUCTURES OF HUMAN STEROIDOGENIC FACTOR-1 ANDTITL 2 LIVER RECEPTOR HOMOLOGUE-1REF PROC.NATL.ACAD.SCI.USA V. 102 7505 2005REFN ISSN 0027-8424PMID 15897460DOI 10.1073/PNAS.0409482102 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1rhf TYRO3 crystal structure of human tyro3-d1d2 1.96Å AUTH C.HEIRING,B.DAHLBACK,Y.A.MULLERTITL LIGAND RECOGNITION AND HOMOPHILIC INTERACTIONS IN TYRO3:TITL 2 STRUCTURAL INSIGHTS INTO THE AXL/TYRO3 RECEPTOR TYROSINETITL 3 KINASE FAMILY.REF J.BIOL.CHEM. V. 279 6952 2004REFN ISSN 0021-9258PMID 14623883DOI 10.1074/JBC.M311750200 Variant Set Distributions Mapped Variants
General Structure Information 2oo4 NOTCH2 structure of lnr-hd (negative regulatory region) from human notch 2 2.0Å AUTH W.R.GORDON,D.VARDAR-ULU,G.HISTEN,C.SANCHEZ-IRIZARRY,AUTH 2 J.C.ASTER,S.C.BLACKLOWTITL STRUCTURAL BASIS FOR AUTOINHIBITION OF NOTCHREF NAT.STRUCT.MOL.BIOL. V. 14 295 2007REFN ISSN 1545-9993PMID 17401372DOI 10.1038/NSMB1227 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1yse SATB1 solution structure of the mar-binding domain of satb1 -1.0Å AUTH H.YAMAGUCHI,M.TATENO,K.YAMASAKITITL SOLUTION STRUCTURE AND DNA-BINDING MODE OF THETITL 2 MATRIX ATTACHMENT REGION-BINDING DOMAIN OF THETITL 3 TRANSCRIPTION FACTOR SATB1 THAT REGULATES THETITL 4 T-CELL MATURATIONREF J.BIOL.CHEM. V. 281 5319 2006REFN ISSN 0021-9258PMID 16371359DOI 10.1074/JBC.M510933200 Variant Set Distributions Mapped Variants