Assessment of Structural Intolerance and Durability
General Structure Information 3rl8 DLG1 crytal structure of hdlg1-pdz2 complexed with apc 2.2Å AUTH Z.ZHANG,H.LI,L.CHEN,X.LU,J.ZHANG,P.XU,K.LIN,G.WUTITL MOLECULAR BASIS FOR THE RECOGNITION OF ADENOMATOUS POLYPOSISTITL 2 COLI BY THE DISCS LARGE 1 PROTEIN.REF PLOS ONE V. 6 23507 2011REFN ESSN 1932-6203PMID 21858148DOI 10.1371/JOURNAL.PONE.0023507 Variant Set Distributions Mapped Variants
General Structure Information 2v64 MAD2L1 crystallographic structure of the conformational dimer of the spindle assembly checkpoint protein mad2. 2.9Å AUTH M.MAPELLI,L.MASSIMILIANO,S.SANTAGUIDA,A.MUSACCHIOTITL THE MAD2 CONFORMATIONAL DIMER: STRUCTURE ANDTITL 2 IMPLICATIONS FOR THE SPINDLE ASSEMBLY CHECKPOINTREF CELL(CAMBRIDGE,MASS.) V. 131 730 2007REFN ISSN 0092-8674PMID 18022367DOI 10.1016/J.CELL.2007.08.049 Variant Set Distributions Mapped Variants
General Structure Information 2qym PDE4C crystal structure of unliganded pde4c2 1.9Å AUTH H.WANG,M.S.PENG,Y.CHEN,J.GENG,H.ROBINSON,AUTH 2 M.D.HOUSLAY,J.CAI,H.KETITL STRUCTURES OF THE FOUR SUBFAMILIES OFTITL 2 PHOSPHODIESTERASE-4 PROVIDE INSIGHT INTO THETITL 3 SELECTIVITY OF THEIR INHIBITORS.REF BIOCHEM.J. V. 408 193 2007REFN ISSN 0264-6021PMID 17727341DOI 10.1042/BJ20070970 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ct2 TRIM32 solution structure of the ring domain of the tripartite motif protein 32 -1.0Å AUTH K.MIYAMOTO,N.TOCHIO,M.SATO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RING DOMAIN OF THETITL 2 TRIPARTITE MOTIF PROTEIN 32REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4oav RNASEL complete human rnase l in complex with 2-5a (5-ppp heptamer), amppcp and rna substrate. 2.1Å AUTH Y.HAN,J.DONOVAN,S.RATH,G.WHITNEY,A.CHITRAKAR,A.KORENNYKHTITL STRUCTURE OF HUMAN RNASE L REVEALS THE BASIS FOR REGULATEDTITL 2 RNA DECAY IN THE IFN RESPONSE.REF SCIENCE V. 343 1244 2014REFN ISSN 0036-8075PMID 24578532DOI 10.1126/SCIENCE.1249845 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1xdv SOS1 experimentally phased structure of human the son of sevenless protein at 4.1 ang. 4.1Å AUTH H.SONDERMANN,S.M.SOISSON,S.BOYKEVISCH,S.S.YANG,AUTH 2 D.BAR-SAGI,J.KURIYANTITL STRUCTURAL ANALYSIS OF AUTOINHIBITION IN THE RASTITL 2 ACTIVATOR SON OF SEVENLESS.REF CELL(CAMBRIDGE,MASS.) V. 119 393 2004REFN ISSN 0092-8674PMID 15507210DOI 10.1016/J.CELL.2004.10.005 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3sag EXOSC10 crystal structure of the human rrp6 catalytic domain with d313n mutation in the active site 2.7Å AUTH K.JANUSZYK,Q.LIU,C.D.LIMATITL ACTIVITIES OF HUMAN RRP6 AND STRUCTURE OF THE HUMAN RRP6TITL 2 CATALYTIC DOMAIN.REF RNA V. 17 1566 2011REFN ISSN 1355-8382PMID 21705430DOI 10.1261/RNA.2763111 Variant Set Distributions Mapped Variants
General Structure Information 2la5 FMR1 rna duplex-quadruplex junction complex with fmrp rgg peptide -1.0Å AUTH A.T.PHAN,V.KURYAVYI,J.C.DARNELL,A.SERGANOV,A.MAJUMDAR,AUTH 2 S.ILIN,T.RASLIN,A.POLONSKAIA,C.CHEN,D.CLAIN,R.B.DARNELL,AUTH 3 D.J.PATELTITL STRUCTURE-FUNCTION STUDIES OF FMRP RGG PEPTIDE RECOGNITIONTITL 2 OF AN RNA DUPLEX-QUADRUPLEX JUNCTION.REF NAT.STRUCT.MOL.BIOL. V. 18 796 2011REFN ISSN 1545-9993PMID 21642970DOI 10.1038/NSMB.2064 Variant Set Distributions Mapped Variants
General Structure Information 2lk9 BST2 structure of bst-2/tetherin transmembrane domain -1.0Å AUTH M.SKASKO,Y.WANG,Y.TIAN,A.TOKAREV,J.MUNGUIA,A.RUIZ,AUTH 2 E.B.STEPHENS,S.J.OPELLA,J.GUATELLITITL HIV-1 VPU PROTEIN ANTAGONIZES INNATE RESTRICTION FACTORTITL 2 BST-2 VIA LIPID-EMBEDDED HELIX-HELIX INTERACTIONS.REF J.BIOL.CHEM. V. 287 58 2012REFN ISSN 0021-9258PMID 22072710DOI 10.1074/JBC.M111.296772 Variant Set Distributions Mapped Variants
General Structure Information 2dt7 SF3A3 solution structure of the second surp domain of human splicing factor sf3a120 in complex with a fragment of human splicing factor sf3a60 -1.0Å AUTH K.KUWASAKO,F.HE,M.INOUE,A.TANAKA,S.SUGANO,AUTH 2 P.GUENTERT,Y.MUTO,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE SURP DOMAINS AND THETITL 2 SUBUNIT-ASSEMBLY MECHANISM WITHIN THE SPLICINGTITL 3 FACTOR SF3A COMPLEX IN 17S U2 SNRNPREF STRUCTURE […]