Assessment of Structural Intolerance and Durability
General Structure Information 3tkr PRDX4 crystal structure of full-length human peroxiredoxin 4 with t118e mutation 2.1Å AUTH X.WANG,L.WANG,X.WANG,F.SUN,C.-C.WANGTITL STRUCTURAL INSIGHTS INTO THE PEROXIDASE ACTIVITY ANDTITL 2 INACTIVATION OF HUMAN PEROXIREDOXIN 4REF BIOCHEM.J. 2011REFN ESSN 1470-8728PMID 21916849DOI 10.1042/BJ20110380 Variant Set Distributions Mapped Variants
General Structure Information 1uv0 REG3A pancreatitis-associated protein 1 from human 1.78Å AUTH C.ABERGEL,S.CHENIVESSE,M.G.STINNAKRE,S.GUASCO,C.BRECHOT,AUTH 2 J.M.CLAVERIE,E.DEVINOY,L.CHRISTATITL CRYSTALLIZATION AND PRELIMINARY CRYSTALLOGRAPHIC STUDY OFTITL 2 HIP/PAP, A HUMAN C-LECTIN OVEREXPRESSED IN PRIMARY LIVERTITL 3 CANCERS.REF ACTA CRYSTALLOGR.,SECT.D V. 55 1487 1999REFN ISSN 0907-4449PMID 10417404 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2dh7 TIAL1 solution structure of the second rna binding domain in nucleolysin tiar -1.0Å AUTH T.IMAI,K.TSUDA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND RNA BINDINGTITL 2 DOMAIN IN NUCLEOLYSIN TIARREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2qyn PDE4D crystal structure of pde4d2 in complex with inhibitor npv 1.57Å AUTH H.WANG,M.S.PENG,Y.CHEN,J.GENG,H.ROBINSON,AUTH 2 M.D.HOUSLAY,J.CAI,H.KETITL STRUCTURES OF THE FOUR SUBFAMILIES OFTITL 2 PHOSPHODIESTERASE-4 PROVIDE INSIGHT INTO THETITL 3 SELECTIVITY OF THEIR INHIBITORS.REF BIOCHEM.J. V. 408 193 2007REFN ISSN 0264-6021PMID 17727341DOI 10.1042/BJ20070970 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3vvw CALCOCO2 ndp52 in complex with lc3c 2.5Å AUTH N.V.MUHLINEN,M.AKUTSU,B.J.RAVENHILL,A.FOEGLEIN,S.BLOOR,AUTH 2 T.J.RUTHERFORD,S.M.FREUND,D.KOMANDER,F.RANDOWTITL LC3C, BOUND SELECTIVELY BY A NONCANONICAL LIR MOTIF INTITL 2 NDP52, IS REQUIRED FOR ANTIBACTERIAL AUTOPHAGYREF MOL.CELL V. 48 329 2012REFN ISSN 1097-2765PMID 23022382DOI 10.1016/J.MOLCEL.2012.08.024 Variant Set Distributions Mapped Variants
General Structure Information 3vvw CALCOCO2 ndp52 in complex with lc3c 2.5Å AUTH N.V.MUHLINEN,M.AKUTSU,B.J.RAVENHILL,A.FOEGLEIN,S.BLOOR,AUTH 2 T.J.RUTHERFORD,S.M.FREUND,D.KOMANDER,F.RANDOWTITL LC3C, BOUND SELECTIVELY BY A NONCANONICAL LIR MOTIF INTITL 2 NDP52, IS REQUIRED FOR ANTIBACTERIAL AUTOPHAGYREF MOL.CELL V. 48 329 2012REFN ISSN 1097-2765PMID 23022382DOI 10.1016/J.MOLCEL.2012.08.024 Variant Set Distributions Mapped Variants
General Structure Information 3vvw CALCOCO2 ndp52 in complex with lc3c 2.5Å AUTH N.V.MUHLINEN,M.AKUTSU,B.J.RAVENHILL,A.FOEGLEIN,S.BLOOR,AUTH 2 T.J.RUTHERFORD,S.M.FREUND,D.KOMANDER,F.RANDOWTITL LC3C, BOUND SELECTIVELY BY A NONCANONICAL LIR MOTIF INTITL 2 NDP52, IS REQUIRED FOR ANTIBACTERIAL AUTOPHAGYREF MOL.CELL V. 48 329 2012REFN ISSN 1097-2765PMID 23022382DOI 10.1016/J.MOLCEL.2012.08.024 Variant Set Distributions Mapped Variants
General Structure Information 2nyl PPP2R5C crystal structure of protein phosphatase 2a (pp2a) holoenzyme with the catalytic subunit carboxyl terminus truncated 3.8Å AUTH Y.XU,Y.XING,Y.CHEN,Y.CHAO,Z.LIN,E.FAN,J.W.YU,S.STRACK,AUTH 2 P.D.JEFFREY,Y.SHITITL STRUCTURE OF THE PROTEIN PHOSPHATASE 2A HOLOENZYME.REF CELL(CAMBRIDGE,MASS.) V. 127 1239 2006REFN ISSN 0092-8674PMID 17174897DOI 10.1016/J.CELL.2006.11.033 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1yc0 HGFAC short form hgfa with first kunitz domain from hai-1 2.6Å AUTH S.SHIA,J.STAMOS,D.KIRCHHOFER,B.FAN,J.WU,R.T.CORPUZ,AUTH 2 L.SANTELL,R.A.LAZARUS,C.EIGENBROTTITL CONFORMATIONAL LABILITY IN SERINE PROTEASE ACTIVE SITES:TITL 2 STRUCTURES OF HEPATOCYTE GROWTH FACTOR ACTIVATOR (HGFA)TITL 3 ALONE AND WITH THE INHIBITORY DOMAIN FROM HGFA INHIBITOR-1B.REF J.MOL.BIOL. V. 346 1335 2005REFN ISSN 0022-2836PMID 15713485DOI 10.1016/J.JMB.2004.12.048 Variant Set […]
General Structure Information 1f3m PAK1 crystal structure of human serine/threonine kinase pak1 2.3Å AUTH M.LEI,W.LU,W.MENG,M.C.PARRINI,M.J.ECK,B.J.MAYER,AUTH 2 S.C.HARRISONTITL STRUCTURE OF PAK1 IN AN AUTOINHIBITED CONFORMATIONTITL 2 REVEALS A MULTISTAGE ACTIVATION SWITCH.REF CELL(CAMBRIDGE,MASS.) V. 102 387 2000REFN ISSN 0092-8674PMID 10975528DOI 10.1016/S0092-8674(00)00043-X Variant Set Distributions Mapped Variants