Assessment of Structural Intolerance and Durability
General Structure Information 2gf5 FADD structure of intact fadd (mort1) -1.0Å AUTH P.E.CARRINGTON,C.SANDU,Y.WEI,J.M.HILL,G.MORISAWA,AUTH 2 T.HUANG,E.GAVATHIOTIS,Y.WEI,M.H.WERNERTITL THE STRUCTURE OF FADD AND ITS MODE OF INTERACTIONTITL 2 WITH PROCASPASE-8REF MOL.CELL V. 22 599 2006REFN ISSN 1097-2765PMID 16762833DOI 10.1016/J.MOLCEL.2006.04.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1avo PSME1 proteasome activator reg(alpha) 2.8Å AUTH J.R.KNOWLTON,S.C.JOHNSTON,F.G.WHITBY,C.REALINI,AUTH 2 Z.ZHANG,M.RECHSTEINER,C.P.HILLTITL STRUCTURE OF THE PROTEASOME ACTIVATOR REGALPHATITL 2 (PA28ALPHA).REF NATURE V. 390 639 1997REFN ISSN 0028-0836PMID 9403698DOI 10.1038/37670 Variant Set Distributions Mapped Variants
General Structure Information 4hzs TNK2 crystal structure of ack1 kinase domain with c-terminal sh3 domain 3.23Å AUTH K.S.GAJIWALA,K.MAEGLEY,R.FERRE,Y.A.HE,X.YUTITL ACK1: ACTIVATION AND REGULATION BY ALLOSTERY.REF PLOS ONE V. 8 53994 2013REFN ESSN 1932-6203PMID 23342057DOI 10.1371/JOURNAL.PONE.0053994 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2enz PRKCQ solution structure of the second c1 domain from human protein kinase c theta -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND C1 DOMAIN FROMTITL 2 HUMAN PROTEIN KINASE C THETAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2xdg GHRHR crystal structure of the extracellular domain of human growth hormone releasing hormone receptor. 1.95Å AUTH A.C.W.PIKE,A.QUIGLEY,A.J.BARR,N.BURGESS BROWN,L.SHRESTHA,AUTH 2 J.YANG,A.CHAIKUAD,M.VOLLMAR,J.R.C.MUNIZ,F.VON DELFT,AUTH 3 A.EDWARDS,C.H.ARROWSMITH,J.WEIGELT,C.BOUNTRA,E.P.CARPENTERTITL CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMANTITL 2 GROWTH HORMONE RELEASING HORMONE RECEPTOR.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3lqh KMT2A crystal structure of mll1 phd3-bromo in the free form 1.72Å AUTH Z.WANG,J.SONG,T.A.MILNE,G.G.WANG,H.LI,C.D.ALLIS,D.J.PATELTITL PRO ISOMERIZATION IN MLL1 PHD3-BROMO CASSETTE CONNECTSTITL 2 H3K4ME READOUT TO CYP33 AND HDAC-MEDIATED REPRESSION.REF CELL(CAMBRIDGE,MASS.) V. 141 1183 2010REFN ISSN 0092-8674PMID 20541251DOI 10.1016/J.CELL.2010.05.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ha8 TARBP1 methyltransferase domain of human tar (hiv-1) rna binding protein 1 1.6Å AUTH H.WU,J.MIN,H.ZENG,P.LOPPNAU,K.BATTAILE,J.WEIGELT,AUTH 2 M.SUNDSTROM,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAINTITL 2 OF HUMAN TAR (HIV-1) RNA BINDING PROTEIN 1 INTITL 3 COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2kie OCRL a ph domain within ocrl bridges clathrin mediated membrane trafficking to phosphoinositide metabolis -1.0Å AUTH Y.MAO,D.M.BALKIN,R.ZONCU,K.S.ERDMANN,L.TOMASINI,AUTH 2 F.HU,M.M.JIN,M.E.HODSDON,P.DE CAMILLITITL A PH DOMAIN WITHIN OCRL BRIDGES CLATHRIN-MEDIATEDTITL 2 MEMBRANE TRAFFICKING TO PHOSPHOINOSITIDE METABOLISMREF EMBO J. V. 28 1831 2009REFN ISSN 0261-4189PMID 19536138DOI 10.1038/EMBOJ.2009.155 Variant Set Distributions Mapped Variants
General Structure Information 3com STK4 crystal structure of mst1 kinase 2.2Å AUTH S.ATWELL,S.K.BURLEY,M.DICKEY,B.LEON,J.M.SAUDERTITL CRYSTAL STRUCTURE OF MST1 KINASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2om5 CNTN2 n-terminal fragment of human tax1 3.07Å AUTH M.MORTL,P.SONDEREGGER,K.DIEDERICHS,W.WELTETITL THE CRYSTAL STRUCTURE OF THE LIGAND-BINDING MODULE OF HUMANTITL 2 TAG-1 SUGGESTS A NEW MODE OF HOMOPHILIC INTERACTIONREF PROTEIN SCI. V. 16 2174 2007REFN ISSN 0961-8368PMID 17766378DOI 10.1110/PS.072802707 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants