Assessment of Structural Intolerance and Durability
General Structure Information 1f2h TRADD solution structure of the n-terminal domain of the tnfr1 associated protein, tradd. -1.0Å AUTH D.H.TSAO,T.MCDONAGH,J.B.TELLIEZ,S.HSU,K.MALAKIAN,AUTH 2 G.Y.XU,L.L.LINTITL SOLUTION STRUCTURE OF N-TRADD AND CHARACTERIZATIONTITL 2 OF THE INTERACTION OF N-TRADD AND C-TRAF2, A KEYTITL 3 STEP IN THE TNFR1 SIGNALING PATHWAY.REF MOL.CELL V. 5 1051 2000REFN ISSN 1097-2765PMID 10911999DOI 10.1016/S1097-2765(00)80270-1 Variant […]
General Structure Information 4hcr MADCAM1 crystal structure of human madcam-1 d1d2 complexed with fab pf-547659 2.3Å AUTH T.SPRINGER,Y.YU,J.ZHU,J.-H.WANG,P.-S.HUANGTITL A DIFFERENT FOLD WITH AN INTEGRIN-BINDING LOOP SPECIALIZEDTITL 2 FOR FLEXIBILITY IN MUCOSAL ADDRESSIN CELL ADHESIONTITL 3 MOLECULE-1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2uvl BIRC3 human bir3 domain of baculoviral inhibitor of apoptosis repeat-containing 3 (birc3) 1.91Å AUTH M.D.HERMAN,M.MOCHE,S.FLODIN,M.WELIN,L.TRESAUGUES,AUTH 2 I.JOHANSSON,M.NILSSON,P.NORDLUND,T.NYMANTITL STRUCTURES OF BIR DOMAINS FROM HUMAN NAIP AND CIAP2.REF ACTA CRYSTALLOGR.,SECT.F V. 65 1091 2009REFN ISSN 1744-3091PMID 19923725DOI 10.1107/S1744309109038597 Variant Set Distributions Mapped Variants
General Structure Information 3uot MDC1 crystal structure of mdc1 fha domain in complex with a phosphorylated peptide from the mdc1 n-terminus 1.8Å AUTH S.JUNGMICHEL,J.A.CLAPPERTON,J.LLOYD,F.J.HARI,C.SPYCHER,AUTH 2 L.PAVIC,J.LI,L.F.HAIRE,M.BONALLI,D.H.LARSEN,C.LUKAS,J.LUKAS,AUTH 3 D.MACMILLAN,M.L.NIELSEN,M.STUCKI,S.J.SMERDONTITL THE MOLECULAR BASIS OF ATM-DEPENDENT DIMERIZATION OF THETITL 2 MDC1 DNA DAMAGE CHECKPOINT MEDIATOR.REF NUCLEIC ACIDS RES. V. 40 3913 2012REFN ISSN 0305-1048PMID 22234878DOI 10.1093/NAR/GKR1300 Variant Set […]
General Structure Information 3uot MDC1 crystal structure of mdc1 fha domain in complex with a phosphorylated peptide from the mdc1 n-terminus 1.8Å AUTH S.JUNGMICHEL,J.A.CLAPPERTON,J.LLOYD,F.J.HARI,C.SPYCHER,AUTH 2 L.PAVIC,J.LI,L.F.HAIRE,M.BONALLI,D.H.LARSEN,C.LUKAS,J.LUKAS,AUTH 3 D.MACMILLAN,M.L.NIELSEN,M.STUCKI,S.J.SMERDONTITL THE MOLECULAR BASIS OF ATM-DEPENDENT DIMERIZATION OF THETITL 2 MDC1 DNA DAMAGE CHECKPOINT MEDIATOR.REF NUCLEIC ACIDS RES. V. 40 3913 2012REFN ISSN 0305-1048PMID 22234878DOI 10.1093/NAR/GKR1300 Variant Set […]
General Structure Information 3uot MDC1 crystal structure of mdc1 fha domain in complex with a phosphorylated peptide from the mdc1 n-terminus 1.8Å AUTH S.JUNGMICHEL,J.A.CLAPPERTON,J.LLOYD,F.J.HARI,C.SPYCHER,AUTH 2 L.PAVIC,J.LI,L.F.HAIRE,M.BONALLI,D.H.LARSEN,C.LUKAS,J.LUKAS,AUTH 3 D.MACMILLAN,M.L.NIELSEN,M.STUCKI,S.J.SMERDONTITL THE MOLECULAR BASIS OF ATM-DEPENDENT DIMERIZATION OF THETITL 2 MDC1 DNA DAMAGE CHECKPOINT MEDIATOR.REF NUCLEIC ACIDS RES. V. 40 3913 2012REFN ISSN 0305-1048PMID 22234878DOI 10.1093/NAR/GKR1300 Variant Set […]
General Structure Information 2z7q RPS6KA1 crystal structure of the n-terminal kinase domain of human rsk-1 bound to amp-pcp 2.0Å AUTH M.IKUTA,M.KORNIENKO,N.BYRNE,J.C.REID,S.MIZUARAI,H.KOTANI,AUTH 2 S.K.MUNSHITITL CRYSTAL STRUCTURES OF THE N-TERMINAL KINASE DOMAIN OF HUMANTITL 2 RSK1 BOUND TO THREE DIFFERENT LIGANDS: IMPLICATIONS FOR THETITL 3 DESIGN OF RSK1 SPECIFIC INHIBITORS.REF PROTEIN SCI. V. 16 2626 2007REFN ISSN […]
General Structure Information 2qag SEPT6 crystal structure of human septin trimer 2/6/7 4.0Å AUTH M.SIRAJUDDIN,M.FARKASOVSKY,F.HAUER,D.KUHLMANN,AUTH 2 I.G.MACARA,M.WEYAND,H.STARK,A.WITTINGHOFERTITL STRUCTURAL INSIGHT INTO FILAMENT FORMATION BYTITL 2 MAMMALIAN SEPTINS.REF NATURE V. 449 311 2007REFN ISSN 0028-0836PMID 17637674DOI 10.1038/NATURE06052 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1xtj DDX39B structure of human uap56 in complex with adp 2.7Å AUTH H.SHI,O.CORDIN,C.M.MINDER,P.LINDER,R.-M.XUTITL CRYSTAL STRUCTURE OF THE HUMAN ATP-DEPENDENTTITL 2 SPLICING AND EXPORT FACTOR UAP56REF PROC.NATL.ACAD.SCI.USA V. 101 17628 2004REFN ISSN 0027-8424PMID 15585580DOI 10.1073/PNAS.0408172101 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4gwr PDIA6 crystal structure of the second catalytic domain of protein disulfide isomerase p5 1.81Å AUTH R.VINAIK,G.KOZLOV,K.GEHRINGTITL TO BE PUBLISHEDREF TO BE PUBLISHED 2013REFN Variant Set Distributions Mapped Variants