Assessment of Structural Intolerance and Durability
General Structure Information 4gmj CNOT7 structure of human not1 mif4g domain co-crystallized with caf1 2.7Å AUTH A.P.PETIT,L.WOHLBOLD,P.BAWANKAR,E.HUNTZINGER,S.SCHMIDT,AUTH 2 E.IZAURRALDE,O.WEICHENRIEDERTITL THE STRUCTURAL BASIS FOR THE INTERACTION BETWEEN THE CAF1TITL 2 NUCLEASE AND THE NOT1 SCAFFOLD OF THE HUMAN CCR4-NOTTITL 3 DEADENYLASE COMPLEXREF NUCLEIC ACIDS RES. V. 40 11058 2012REFN ISSN 0305-1048PMID 22977175DOI 10.1093/NAR/GKS883 Variant Set Distributions […]
General Structure Information 3kv4 PHF8 structure of phf8 in complex with histone h3 2.19Å AUTH J.R.HORTON,A.K.UPADHYAY,H.H.QI,X.ZHANG,Y.SHI,AUTH 2 X.CHENGTITL ENZYMATIC AND STRUCTURAL INSIGHTS FOR SUBSTRATETITL 2 SPECIFICITY OF A FAMILY OF JUMONJI HISTONE LYSINETITL 3 DEMETHYLASES.REF NAT.STRUCT.MOL.BIOL. V. 17 38 2010REFN ISSN 1545-9993PMID 20023638DOI 10.1038/NSMB.1753 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4avm BIN2 crystal structure of the n-bar domain of human bridging integrator 2. 1.91Å AUTH C.K.ALLERSTON,T.KROJER,C.D.O.COOPER,M.VOLLMAR,AUTH 2 C.H.ARROWSMITH,A.EDWARDS,C.BOUNTRA,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURE OF THE N-BAR DOMAIN OF HUMAN BRIDGINGTITL 2 INTEGRATOR 2.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4lu3 CA14 the crystal structure of the human carbonic anhydrase xiv 2.0Å AUTH V.ALTERIO,P.PAN,S.PARKKILA,M.BUONANNO,C.T.SUPURAN,S.M.MONTI,AUTH 2 G.DE SIMONETITL THE STRUCTURAL COMPARISON BETWEEN MEMBRANE-ASSOCIATED HUMANTITL 2 CARBONIC ANHYDRASES PROVIDES INSIGHTS INTO DRUG DESIGN OFTITL 3 SELECTIVE INHIBITORS.REF BIOPOLYMERS V. 101 769 2014REFN ISSN 0006-3525PMID 24374484DOI 10.1002/BIP.22456 Variant Set Distributions Mapped Variants
General Structure Information 2lkt RARRES3 solution structure of n-terminal domain of human tig3 in 2 m urea -1.0Å AUTH L.WANG,W.YU,X.REN,J.LIN,C.JIN,B.XIATITL (1)H, (13)C, AND (15)N RESONANCE ASSIGNMENTS OF THETITL 2 N-TERMINAL DOMAIN OF HUMAN TIG3REF BIOMOL.NMR ASSIGN. V. 6 201 2012REFN ISSN 1874-2718PMID 22290676DOI 10.1007/S12104-012-9357-2 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4g34 EIF2AK3 crystal structure of gsk6924 bound to perk (r587-r1092, delete a660- t867) at 2.70 a resolution 2.7Å AUTH J.M.AXTEN,J.R.MEDINA,Y.FENG,A.SHU,S.P.ROMERIL,S.W.GRANT,AUTH 2 W.H.LI,D.A.HEERDING,E.MINTHORN,T.MENCKEN,C.ATKINS,Q.LIU,AUTH 3 S.RABINDRAN,R.KUMAR,X.HONG,A.GOETZ,T.STANLEY,J.D.TAYLOR,AUTH 4 S.D.SIGETHY,G.H.TOMBERLIN,A.M.HASSELL,K.M.KAHLER,AUTH 5 L.M.SHEWCHUK,R.T.GAMPETITL DISCOVERY OFTITL 2 7-METHYL-5-(1-{[3-(TRIFLUOROMETHYL)PHENYL]ACETYL}-2,3-TITL 3 DIHYDRO-1H-INDOL-5-YL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINETITL 4 (GSK2606414), A POTENT AND SELECTIVE FIRST-IN-CLASSTITL 5 INHIBITOR OF PROTEIN KINASE R (PKR)-LIKE ENDOPLASMICTITL 6 RETICULUM KINASE […]
General Structure Information 3rzn GLTP crystal structure of human glycolipid transfer protein complexed with 3-o-sulfo-galactosylceramide containing nervonoyl acyl chain (24:1) 1.1Å AUTH V.R.SAMYGINA,A.N.POPOV,A.CABO-BILBAO,B.OCHOA-LIZARRALDE,AUTH 2 F.GONI-DE-CERIO,X.ZHAI,J.G.MOLOTKOVSKY,D.J.PATEL,R.E.BROWN,AUTH 3 L.MALININATITL ENHANCED SELECTIVITY FOR SULFATIDE BY ENGINEERED HUMANTITL 2 GLYCOLIPID TRANSFER PROTEIN.REF STRUCTURE V. 19 1644 2011REFN ISSN 0969-2126PMID 22078563DOI 10.1016/J.STR.2011.09.011 Variant Set Distributions Mapped Variants
General Structure Information 2kdg MYOT solution structure of the 1st ig domain of myotilin -1.0Å AUTH O.HEIKKINEN,P.PERMI,H.KOSKELA,O.CARPEN,J.YLANNE,AUTH 2 I.KILPELAINENTITL SOLUTION STRUCTURE OF THE FIRST IMMUNOGLOBULINTITL 2 DOMAIN OF HUMAN MYOTILINREF J.BIOMOL.NMR V. 44 107 2009REFN ISSN 0925-2738PMID 19418025DOI 10.1007/S10858-009-9320-4 Variant Set Distributions Mapped Variants
General Structure Information 4ch9 KLHL3 crystal structure of the human klhl3 kelch domain in complex with a wnk4 peptide 1.84Å AUTH F.SCHUMACHER,F.J.SORRELL,D.R.ALESSI,A.N.BULLOCK,T.KURZTITL STRUCTURAL AND BIOCHEMICAL CHARACTERISATION OF THE KLHL3-TITL 2 WNK KINASE INTERACTION IMPORTANT IN BLOOD PRESSURETITL 3 REGULATION.REF BIOCHEM.J. V. 460 237 2014REFN ISSN 0264-6021PMID 24641320DOI 10.1042/BJ20140153 Variant Set Distributions Mapped Variants
General Structure Information 1iur SACS dnaj domain of human kiaa0730 protein -1.0Å AUTH N.KOBAYASHI,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF DNAJ DOMAIN OF HUMANTITL 2 KIAA0730 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants