Assessment of Structural Intolerance and Durability
General Structure Information 2axl WRN solution structure of a multifunctional dna- and protein- binding domain of human werner syndrome protein -1.0Å AUTH J.-S.HU,H.FENG,W.ZENG,G.-X.LIN,X.G.XITITL SOLUTION STRUCTURE OF A MULTIFUNCTIONAL DNA- ANDTITL 2 PROTEIN-BINDING MOTIF OF HUMAN WERNER SYNDROMETITL 3 PROTEIN.REF PROC.NATL.ACAD.SCI.USA V. 102 18379 2005REFN ISSN 0027-8424PMID 16339893DOI 10.1073/PNAS.0509380102 Variant Set Distributions Mapped Variants
General Structure Information 2m0g SF1 structure, phosphorylation and u2af65 binding of the nterminal domain of splicing factor 1 during 3 splice site recognition -1.0Å AUTH Y.ZHANG,T.MADL,I.BAGDIUL,T.KERN,H.S.KANG,P.ZOU,N.MAUSBACHER,AUTH 2 S.A.SIEBER,A.KRAMER,M.SATTLERTITL STRUCTURE, PHOSPHORYLATION AND U2AF65 BINDING OF THETITL 2 N-TERMINAL DOMAIN OF SPLICING FACTOR 1 DURING 3-SPLICE SITETITL 3 RECOGNITION.REF NUCLEIC ACIDS RES. V. 41 1343 2013REFN ISSN […]
General Structure Information 4o9b STIM1 the structure of cc1-ih in human stim1. 2.6Å AUTH B.CUI,X.YANG,S.LI,Z.LIN,Z.WANG,C.DONG,Y.SHENTITL THE INHIBITORY HELIX CONTROLS THE INTRAMOLECULARTITL 2 CONFORMATIONAL SWITCHING OF THE C-TERMINUS OF STIM1.REF PLOS ONE V. 8 74735 2013REFN ESSN 1932-6203PMID 24069340DOI 10.1371/JOURNAL.PONE.0074735 Variant Set Distributions Mapped Variants
General Structure Information 4ed5 ELAVL1 crystal structure of the two n-terminal rrm domains of hur complexed with rna 2.0Å AUTH H.WANG,F.ZENG,Q.LIU,H.LIU,Z.LIU,L.NIU,M.TENG,X.LITITL THE STRUCTURE OF THE ARE-BINDING DOMAINS OF HU ANTIGEN RTITL 2 (HUR) UNDERGOES CONFORMATIONAL CHANGES DURING RNA BINDING.REF ACTA CRYSTALLOGR.,SECT.D V. 69 373 2013REFN ISSN 0907-4449PMID 23519412DOI 10.1107/S0907444912047828 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3i35 LASP1 human sh3 domain of protein lasp1 1.4Å AUTH M.I.SIPONEN,A.K.ROOS,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T KOTENYOVA,A.KOTZSCH,T.KRAGH NIELSEN,M.MOCHE,T.NYMAN,AUTH 5 C.PERSSON,J.SAGEMARK,H.SCHUELER,P.SCHUTZ,A.G.THORSELL,AUTH 6 L.TRESAUGUES,S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WISNIEWSKA,AUTH 7 P.NORDLUNDTITL HUMAN SH3 DOMAIN OF PROTEIN LASP1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3f7p PLEC crystal structure of a complex between integrin beta4 and plectin 2.75Å AUTH J.M.DE PEREDA,M.P.LILLO,A.SONNENBERGTITL STRUCTURAL BASIS OF THE INTERACTION BETWEENTITL 2 INTEGRIN ALPHA6BETA4 AND PLECTIN AT THETITL 3 HEMIDESMOSOMESREF EMBO J. V. 28 1180 2009REFN ISSN 0261-4189PMID 19242489DOI 10.1038/EMBOJ.2009.48 Variant Set Distributions Mapped Variants
General Structure Information 2le8 MCM6 the protein complex for dna replication -1.0Å AUTH C.LIU,Z.WEI,R.WU,C.LIANG,G.ZHUTITL THE PROTEIN COMPLEX FOR DNA REPLICATIONREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2e1e WRN crystal structure of the hrdc domain of human werner syndrome protein, wrn 2.3Å AUTH K.KITANO,N.YOSHIHARA,T.HAKOSHIMATITL CRYSTAL STRUCTURE OF THE HRDC DOMAIN OF HUMAN WERNERTITL 2 SYNDROME PROTEIN, WRNREF J.BIOL.CHEM. V. 282 2717 2007REFN ISSN 0021-9258PMID 17148451DOI 10.1074/JBC.M610142200 Variant Set Distributions Mapped Variants
General Structure Information 2bzl PTPN14 crystal structure of the human protein tyrosine phosphatase n14 at 1.65 a resolution 1.65Å AUTH A.J.BARR,J.E.DEBRECZENI,J.ESWARAN,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINETITL 2 PHOSPHATASE 14 (PTPN14) AT 1.65-A RESOLUTION.REF PROTEINS V. 63 1132 2006REFN ISSN 0887-3585PMID 16534812DOI 10.1002/PROT.20958 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1zkl PDE7A multiple determinants for inhibitor selectivity of cyclic nucleotide phosphodiesterases 1.67Å AUTH H.WANG,Y.LIU,Y.CHEN,H.ROBINSON,H.KETITL MULTIPLE ELEMENTS JOINTLY DETERMINE INHIBITORTITL 2 SELECTIVITY OF CYCLIC NUCLEOTIDETITL 3 PHOSPHODIESTERASES 4 AND 7REF J.BIOL.CHEM. V. 280 30949 2005REFN ISSN 0021-9258PMID 15994308DOI 10.1074/JBC.M504398200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]