Assessment of Structural Intolerance and Durability
General Structure Information 2vcv GSTA3 glutathione transferase a3-3 in complex with glutathione and delta-4-androstene-3-17-dione 1.8Å AUTH K.TARS,B.OLIN,B.MANNERVIKTITL STRUCTURAL BASIS FOR FEATURING OF STEROID ISOMERASETITL 2 ACTIVITY IN ALPHA CLASS GLUTATHIONE TRANSFERASES.REF J.MOL.BIOL. V. 397 332 2010REFN ISSN 0022-2836PMID 20083122DOI 10.1016/J.JMB.2010.01.023 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3i7p DCAF12 crystal structure of ddb1 in complex with the h-box motif of wdr40a 3.0Å AUTH T.LI,E.I.ROBERT,P.C.VAN BREUGEL,M.STRUBIN,N.ZHENGTITL A PROMISCUOUS ALPHA-HELICAL MOTIF ANCHORS VIRALTITL 2 HIJACKERS AND SUBSTRATE RECEPTORS TO THE CUL4-DDB1TITL 3 UBIQUITIN LIGASE MACHINERY.REF NAT.STRUCT.MOL.BIOL. V. 17 105 2010REFN ISSN 1545-9993PMID 19966799DOI 10.1038/NSMB.1719 Variant Set Distributions Mapped Variants
General Structure Information 2vns STEAP3 crystal structure of the membrane proximal oxidoreductase domain of human steap3, the dominant ferric reductase of the erythroid transferrin cycle 2.0Å AUTH A.K.SENDAMARAI,R.S.OHGAMI,M.D.FLEMING,C.M.LAWRENCETITL STRUCTURE OF THE MEMBRANE PROXIMAL OXIDOREDUCTASETITL 2 DOMAIN OF HUMAN STEAP3, THE DOMINANTTITL 3 FERRIREDUCTASE OF THE ERYTHROID TRANSFERRIN CYCLEREF PROC.NATL.ACAD.SCI.USA V. 105 7410 2008REFN ISSN 0027-8424PMID […]
General Structure Information 2y4i KSR2 ksr2-mek1 heterodimer 3.46Å AUTH D.F.BRENNAN,A.C.DAR,N.T.HERTZ,W.CHAO,A.L.BURLINGAME,AUTH 2 K.M.SHOKAT,D.BARFORDTITL A RAF-INDUCED ALLOSTERIC TRANSITION OF KSR STIMULATES KSRTITL 2 AND RAF PHOSPHORYLATION OF MEKREF NATURE V. 472 366 2011REFN ISSN 0028-0836PMID 21441910DOI 10.1038/NATURE09860 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4dou ADIPOQ crystal structure of a single-chain trimer of human adiponectin globular domain 2.0Å AUTH X.MIN,B.LEMON,J.TANG,Q.LIU,R.ZHANG,N.WALKER,Y.LI,Z.WANGTITL CRYSTAL STRUCTURE OF A SINGLE-CHAIN TRIMER OF HUMANTITL 2 ADIPONECTIN GLOBULAR DOMAIN.REF FEBS LETT. V. 586 912 2012REFN ISSN 0014-5793PMID 22449980DOI 10.1016/J.FEBSLET.2012.02.024 Variant Set Distributions Mapped Variants
General Structure Information 3ldb JMJD6 structure of jmjd6 complexd with alpha-ketoglutarate and fab fragment. 2.7Å AUTH X.HONG,J.ZANG,J.WHITE,C.WANG,C.H.PAN,R.ZHAO,R.C.MURPHY,AUTH 2 S.DAI,P.HENSON,J.W.KAPPLER,J.HAGMAN,G.ZHANGTITL INTERACTION OF JMJD6 WITH SINGLE-STRANDED RNA.REF PROC.NATL.ACAD.SCI.USA V. 107 14568 2010REFN ISSN 0027-8424PMID 20679243DOI 10.1073/PNAS.1008832107 Variant Set Distributions Mapped Variants
General Structure Information 2edv FRMPD1 solution structure of the pdz domain from human ferm and pdz domain containing 1 -1.0Å AUTH K.SEIMIYA,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PDZ DOMAIN FROM HUMANTITL 2 FERM AND PDZ DOMAIN CONTAINING 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2edr OBSCN solution structure of the ig-like domain (3361-3449) of human obscurin -1.0Å AUTH C.KUROSAKI,K.IZUMI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE IG-LIKE DOMAINTITL 2 (3361-3449) OF HUMAN OBSCURINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1mkp DUSP6 crystal structure of pyst1 (mkp3) 2.35Å AUTH A.E.STEWART,S.DOWD,S.M.KEYSE,N.Q.MCDONALDTITL CRYSTAL STRUCTURE OF THE MAPK PHOSPHATASE PYST1TITL 2 CATALYTIC DOMAIN AND IMPLICATIONS FOR REGULATEDTITL 3 ACTIVATION.REF NAT.STRUCT.BIOL. V. 6 174 1999REFN ISSN 1072-8368PMID 10048930DOI 10.1038/5861 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3pmi MUM1 pwwp domain of human mutated melanoma-associated antigen 1 2.82Å AUTH H.WU,H.ZENG,R.LAM,W.TEMPEL,M.F.AMAYA,C.XU,L.DOMBROVSKI,AUTH 2 W.QIU,Y.WANG,J.MINTITL STRUCTURAL AND HISTONE BINDING ABILITY CHARACTERIZATIONS OFTITL 2 HUMAN PWWP DOMAINS.REF PLOS ONE V. 6 18919 2011REFN ESSN 1932-6203PMID 21720545DOI 10.1371/JOURNAL.PONE.0018919 Variant Set Distributions Mapped Variants