Assessment of Structural Intolerance and Durability
General Structure Information 3ddt TRIM63 crystal structure of the b2 box from murf1 in dimeric state 1.9Å AUTH M.MROSEK,S.MEIER,Z.UCURUM-FOTIADIS,E.VON CASTELMUR,AUTH 2 E.HEDBOM,A.LUSTIG,S.GRZESIEK,D.LABEIT,S.LABEIT,AUTH 3 O.MAYANSTITL STRUCTURAL ANALYSIS OF B-BOX 2 FROM MURF1:TITL 2 IDENTIFICATION OF A NOVEL SELF-ASSOCIATION PATTERNTITL 3 IN A RING-LIKE FOLDREF BIOCHEMISTRY V. 47 10722 2008REFN ISSN 0006-2960PMID 18795805DOI 10.1021/BI800733Z Variant Set Distributions […]
General Structure Information 1qzu PPCDC crystal structure of human phosphopantothenoylcysteine decarboxylase 2.91Å AUTH N.MANOJ,S.E.EALICKTITL UNUSUAL SPACE-GROUP PSEUDOSYMMETRY IN CRYSTALS OF HUMANTITL 2 PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE.REF ACTA CRYSTALLOGR.,SECT.D V. 59 1762 2003REFN ISSN 0907-4449PMID 14501115DOI 10.1107/S0907444903016214 Variant Set Distributions Mapped Variants
General Structure Information 3bl7 DCPS synthetic gene encoded dcps bound to inhibitor dg156844 2.31Å AUTH J.SINGH,M.SALCIUS,S.W.LIU,B.L.STAKER,R.MISHRA,AUTH 2 J.THURMOND,G.MICHAUD,D.R.MATTOON,J.PRINTEN,AUTH 3 J.CHRISTENSEN,J.M.BJORNSSON,B.A.POLLOK,M.KILEDJIAN,AUTH 4 L.STEWART,J.JARECKI,M.E.GURNEYTITL DCPS AS A THERAPEUTIC TARGET FOR SPINAL MUSCULARTITL 2 ATROPHY.REF ACS CHEM.BIOL. V. 3 711 2008REFN ISSN 1554-8929PMID 18839960DOI 10.1021/CB800120T Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2gw6 TSEN15 nmr structure of the human trna endonuclease sen15 subunit -1.0Å AUTH J.SONG,J.L.MARKLEYTITL THREE-DIMENSIONAL STRUCTURE DETERMINED FOR ATITL 2 SUBUNIT OF HUMAN TRNA SPLICING ENDONUCLEASETITL 3 (SEN15) REVEALS A NOVEL DIMERIC FOLD.REF J.MOL.BIOL. V. 366 155 2007REFN ISSN 0022-2836PMID 17166513DOI 10.1016/J.JMB.2006.11.024 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3le4 DGCR8 crystal structure of the dgcr8 dimerization domain 1.7Å AUTH R.SENTURIA,M.FALLER,S.YIN,J.A.LOO,D.CASCIO,M.R.SAWAYA,AUTH 2 D.HWANG,R.T.CLUBB,F.GUOTITL STRUCTURE OF THE DIMERIZATION DOMAIN OF DIGEORGE CRITICALTITL 2 REGION 8REF PROTEIN SCI. V. 19 1354 2010REFN ISSN 0961-8368PMID 20506313DOI 10.1002/PRO.414 Variant Set Distributions Mapped Variants
General Structure Information 2r02 PDCD6IP crystal structure of alix/aip1 in complex with the hiv-1 ypltsl late domain 2.6Å AUTH Q.ZHAI,R.D.FISHER,H.Y.CHUNG,D.G.MYSZKA,AUTH 2 W.I.SUNDQUIST,C.P.HILLTITL STRUCTURAL AND FUNCTIONAL STUDIES OF ALIXTITL 2 INTERACTIONS WITH YPX(N)L LATE DOMAINS OF HIV-1TITL 3 AND EIAV.REF NAT.STRUCT.MOL.BIOL. V. 15 43 2008REFN ISSN 1545-9993PMID 18066081DOI 10.1038/NSMB1319 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3tjo HTRA1 htra1 catalytic domain, mutationally inactivated 2.3Å AUTH C.EIGENBROT,M.ULTSCH,M.T.LIPARI,P.MORAN,S.J.LIN,R.GANESAN,AUTH 2 C.QUAN,J.TOM,W.SANDOVAL,M.VAN LOOKEREN CAMPAGNE,D.KIRCHHOFERTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF HTRA1 AND ITSTITL 2 SUBDOMAINS.REF STRUCTURE V. 20 1040 2012REFN ISSN 0969-2126PMID 22578544DOI 10.1016/J.STR.2012.03.021 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2hm2 PYDC1 solution structure of asc2 -1.0Å AUTH A.NATARAJAN,R.GHOSE,J.M.HILLTITL STRUCTURE AND DYNAMICS OF ASC2, A PYRINTITL 2 DOMAIN-ONLY PROTEIN THAT REGULATES INFLAMMATORYTITL 3 SIGNALINGREF J.BIOL.CHEM. V. 281 31863 2006REFN ISSN 0021-9258PMID 16905547DOI 10.1074/JBC.M605458200 Variant Set Distributions Mapped Variants
General Structure Information 3tmo OTUD5 the catalytic domain of human deubiquitinase duba 2.2Å AUTH O.W.HUANG,X.MA,J.YIN,J.FLINDERS,T.MAURER,N.KAYAGAKI,Q.PHUNG,AUTH 2 I.BOSANAC,D.ARNOTT,V.M.DIXIT,S.G.HYMOWITZ,M.A.STAROVASNIK,AUTH 3 A.G.COCHRANTITL PHOSPHORYLATION-DEPENDENT ACTIVITY OF THE DEUBIQUITINASETITL 2 DUBA.REF NAT.STRUCT.MOL.BIOL. V. 19 171 2012REFN ISSN 1545-9993PMID 22245969DOI 10.1038/NSMB.2206 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2jk9 SPSB1 the structure of spla-ryanodine receptor domain and socs box containing 1 in complex with a par-4 peptide 1.79Å AUTH P.FILIPPAKOPOULOS,A.LOW,T.D.SHARPE,J.UPPENBERG,S.YAO,AUTH 2 Z.KUANG,P.SAVITSKY,R.S.LEWIS,S.E.NICHOLSON,R.S.NORTON,AUTH 3 A.BULLOCKTITL STRUCTURAL BASIS FOR PAR-4 RECOGNITION BY THE SPRY DOMAIN-TITL 2 AND SOCS BOX-CONTAINING PROTEINS SPSB1, SPSB2, AND SPSB4.REF J.MOL.BIOL. V. 401 389 2010REFN ISSN 0022-2836PMID 20561531DOI […]