Assessment of Structural Intolerance and Durability
General Structure Information 2k6g RFC1 solution structure of the dna binding brct domain from the large subunit of human replication factor c -1.0Å AUTH M.KOBAYASHI,E.AB,A.M.J.J.BONVIN,G.SIEGALTITL SOLUTION STRUCTURE OF THE DNA BOUND BRCT DOMAINTITL 2 FROM HUMAN REPLICATION FACTOR C P140REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4bsj FLT4 crystal structure of vegfr-3 extracellular domains d4-5 2.5Å AUTH V.-M.LEPPANEN,D.TVOROGOV,K.KISKO,A.E.PROTA,M.JELTSCH,AUTH 2 A.ANISIMOV,S.MARKOVIC-MUELLER,E.STUTTFELD,K.N.GOLDIE,AUTH 3 K.BALLMER-HOFER,K.ALITALOTITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO VEGFR-3 LIGANDTITL 2 BINDING AND ACTIVATIONREF PROC.NATL.ACAD.SCI.USA V. 110 12960 2013REFN ISSN 0027-8424PMID 23878260DOI 10.1073/PNAS.1301415110 Variant Set Distributions Mapped Variants
General Structure Information 3fmp NUP214 crystal structure of the nucleoporin nup214 in complex with the dead- box helicase ddx19 3.19Å AUTH J.NAPETSCHNIG,S.A.KASSUBE,E.W.DEBLER,R.W.WONG,G.BLOBEL,AUTH 2 A.HOELZTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE INTERACTIONTITL 2 BETWEEN THE NUCLEOPORIN NUP214 AND THE DEAD-BOX HELICASETITL 3 DDX19.REF PROC.NATL.ACAD.SCI.USA V. 106 3089 2009REFN ISSN 0027-8424PMID 19208808DOI 10.1073/PNAS.0813267106 Variant Set Distributions Ripley’s […]
General Structure Information 2dm0 TXK solution structure of the sh2 domain of human tyrosine- protein kinase txk -1.0Å AUTH H.ENDO,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH2 DOMAIN OF HUMANTITL 2 TYROSINE-PROTEIN KINASE TXKREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3qs9 FLT3 crystal structure of a human flt3 ligand-receptor ternary complex 7.8Å AUTH K.VERSTRAETE,G.VANDRIESSCHE,M.JANUAR,J.ELEGHEERT,AUTH 2 A.V.SHKUMATOV,A.DESFOSSES,K.VAN CRAENENBROECK,D.I.SVERGUN,AUTH 3 I.GUTSCHE,B.VERGAUWEN,S.N.SAVVIDESTITL STRUCTURAL INSIGHTS INTO THE EXTRACELLULAR ASSEMBLY OF THETITL 2 HEMATOPOIETIC FLT3 SIGNALING COMPLEX.REF BLOOD V. 118 60 2011REFN ISSN 0006-4971PMID 21389326DOI 10.1182/BLOOD-2011-01-329532 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1ytq CRYBB2 structure of native human beta b2 crystallin 1.7Å AUTH M.A.SMITH,O.A.BATEMAN,R.JAENICKE,C.SLINGSBYTITL MUTATION OF INTERFACES IN DOMAIN-SWAPPED HUMANTITL 2 BETAB2-CRYSTALLINREF PROTEIN SCI. V. 16 615 2007REFN ISSN 0961-8368PMID 17327390DOI 10.1110/PS.062659107 Variant Set Distributions Mapped Variants
General Structure Information 4h80 ALDH3A1 crystal structure of human aldh3a1 with its isozyme selective inhibitor – n-[4-(4-methylsulfonyl-2-nitroanilino)phenyl]acetamide 2.5Å AUTH B.PARAJULI,T.GEORGIADIS,M.L.FISHEL,T.D.HURLEYTITL KINETIC AND STRUCTURAL CHARACTERIZATION OF A SELECTIVETITL 2 INHIBITOR FOR HUMAN ALDH3A1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2psr S100A7 human psoriasin (s100a7) ca2+ and zn2+ bound form (crystal form ii) 2.05Å AUTH D.E.BRODERSEN,J.NYBORG,M.KJELDGAARDTITL ZINC-BINDING SITE OF AN S100 PROTEIN REVEALED. TWO CRYSTALTITL 2 STRUCTURES OF CA2+-BOUND HUMAN PSORIASIN (S100A7) IN THETITL 3 ZN2+-LOADED AND ZN2+-FREE STATES.REF BIOCHEMISTRY V. 38 1695 1999REFN ISSN 0006-2960PMID 10026247DOI 10.1021/BI982483D Variant Set Distributions Ripley’s […]
General Structure Information 2v40 ADSS human adenylosuccinate synthetase isozyme 2 in complex with gdp 1.9Å AUTH M.WELIN,M.MOCHE,C.ARROWSMITH,H.BERGLUND,R.BUSAM,AUTH 2 R.COLLINS,L.G.DAHLGREN,A.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,B.M.HALLBERG,AUTH 4 L.HOLMBERG-SCHIAVONE,I.JOHANSSON,A.KALLAS,AUTH 5 T.KARLBERG,T.KOTENYOVA,L.LEHTIO,T.NYMAN,D.OGG,AUTH 6 C.PERSSON,J.SAGEMARK,P.STENMARK,M.SUNDSTROM,AUTH 7 A.G.THORSELL,S.VAN-DEN-BERG,J.WEIGELT,P.NORDLUNDTITL HUMAN ADENYLOSUCCINATE SYNTHETASE ISOZYME 2 INTITL 2 COMPLEX WITH GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3w82 IDUA human alpha-l-iduronidase in complex with iduronic acid 2.76Å AUTH N.MAITA,T.TSUKIMURA,T.TANIGUCHI,S.SAITO,K.OHNO,H.TANIGUCHI,AUTH 2 H.SAKURABATITL HUMAN ALPHA-L-IDURONIDASE USES ITS OWN N-GLYCAN AS ATITL 2 SUBSTRATE-BINDING AND CATALYTIC MODULEREF PROC.NATL.ACAD.SCI.USA V. 110 14628 2013REFN ISSN 0027-8424PMID 23959878DOI 10.1073/PNAS.1306939110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants