Assessment of Structural Intolerance and Durability
General Structure Information 3rbn MLH1 crystal structure of mutl protein homolog 1 isoform 1 [homo sapiens] 2.16Å AUTH L.DOMBROVSKY,A.DONG,A.WERNIMONT,P.LOPPNAU,C.BOUNTRA,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,H.WUTITL CRYSTAL STRUCTURE OF MUTL PROTEIN HOMOLOG 1 ISOFORM 1 [HOMOTITL 2 SAPIENS]REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1vd2 PRKCI solution structure of the pb1 domain of pkciota -1.0Å AUTH Y.HIRANO,S.YOSHINAGA,K.OGURA,M.YOKOCHI,Y.NODA,AUTH 2 H.SUMIMOTO,F.INAGAKITITL SOLUTION STRUCTURE OF ATYPICAL PROTEIN KINASE CTITL 2 PB1 DOMAIN AND ITS MODE OF INTERACTION WITHTITL 3 ZIP/P62 AND MEK5REF J.BIOL.CHEM. V. 279 31883 2004REFN ISSN 0021-9258PMID 15143057DOI 10.1074/JBC.M403092200 Variant Set Distributions Mapped Variants
General Structure Information 1t0p ICAM3 structural basis of icam recognition by integrin alpahlbeta2 revealed in the complex structure of binding domains of icam-3 and alphalbeta2 at 1.65 a 1.66Å AUTH G.SONG,Y.YANG,J.H.LIU,J.M.CASASNOVAS,M.SHIMAOKA,AUTH 2 T.A.SPRINGER,J.H.WANGTITL AN ATOMIC RESOLUTION VIEW OF ICAM RECOGNITION IN A COMPLEXTITL 2 BETWEEN THE BINDING DOMAINS OF ICAM-3 AND INTEGRINTITL 3 ALPHALBETA2.REF PROC.NATL.ACAD.SCI.USA […]
General Structure Information 4dcn ARL1 crystal structure analysis of the arfaptin2 bar domain in complex with arl1 3.01Å AUTH K.NAKAMURA,Z.MAN,Y.XIE,A.HANAI,H.MAKYIO,M.KAWASAKI,R.KATO,AUTH 2 H.-W.SHIN,K.NAKAYAMA,S.WAKATSUKITITL STRUCTURAL BASIS FOR MEMBRANE BINDING SPECIFICITY OF THETITL 2 BIN/AMPHIPHYSIN/RVS (BAR) DOMAIN OF ARFAPTIN-2 DETERMINED BYTITL 3 ARL1 GTPASEREF J.BIOL.CHEM. V. 287 25478 2012REFN ISSN 0021-9258PMID 22679020DOI 10.1074/JBC.M112.365783 Variant Set Distributions Ripley’s K […]
General Structure Information 3r7s CASP2 crystal structure of apo caspase2 2.25Å AUTH Y.TANG,J.A.WELLS,M.R.ARKINTITL STRUCTURAL AND ENZYMATIC INSIGHTS INTO CASPASE-2 PROTEINTITL 2 SUBSTRATE RECOGNITION AND CATALYSIS.REF J.BIOL.CHEM. V. 286 34147 2011REFN ISSN 0021-9258PMID 21828056DOI 10.1074/JBC.M111.247627 Variant Set Distributions Mapped Variants
General Structure Information 3q8k FEN1 crystal structure of human flap endonuclease fen1 (wt) in complex with product 5-flap dna, sm3+, and k+ 2.2Å AUTH S.E.TSUTAKAWA,S.CLASSEN,B.R.CHAPADOS,A.S.ARVAI,L.D.FINGER,AUTH 2 G.GUENTHER,C.G.TOMLINSON,P.THOMPSON,A.H.SARKER,B.SHEN,AUTH 3 P.K.COOPER,J.A.GRASBY,J.A.TAINERTITL HUMAN FLAP ENDONUCLEASE STRUCTURES, DNA DOUBLE-BASETITL 2 FLIPPING, AND A UNIFIED UNDERSTANDING OF THE FEN1TITL 3 SUPERFAMILY.REF CELL(CAMBRIDGE,MASS.) V. 145 198 2011REFN ISSN 0092-8674PMID 21496641DOI 10.1016/J.CELL.2011.03.004 […]
General Structure Information 2jdr AKT2 structure of pkb-beta (akt2) complexed with the inhibitor a- 443654 2.3Å AUTH T.G.DAVIES,M.L.VERDONK,B.GRAHAM,S.SAALAU-BETHELL,AUTH 2 C.C.F.HAMLETT,T.MCHARDY,I.COLLINS,M.D.GARRETT,AUTH 3 P.WORKMAN,S.J.WOODHEAD,H.JHOTI,D.BARFORDTITL A STRUCTURAL COMPARISON OF INHIBITOR BINDING TOTITL 2 PKB, PKA AND PKA-PKB CHIMERAREF J.MOL.BIOL. V. 367 882 2007REFN ISSN 0022-2836PMID 17275837DOI 10.1016/J.JMB.2007.01.004 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3b5h BSG crystal structure of the extracellular portion of hab18g/cd147 2.8Å AUTH X.L.YU,T.HU,J.M.DU,J.P.DING,X.M.YANG,J.ZHANG,B.YANG,X.SHEN,AUTH 2 Z.ZHANG,W.D.ZHONG,N.WEN,H.JIANG,P.ZHU,Z.N.CHENTITL CRYSTAL STRUCTURE OF HAB18G/CD147: IMPLICATIONS FORTITL 2 IMMUNOGLOBULIN SUPERFAMILY HOMOPHILIC ADHESION.REF J.BIOL.CHEM. V. 283 18056 2008REFN ISSN 0021-9258PMID 18430721DOI 10.1074/JBC.M802694200 Variant Set Distributions Mapped Variants
General Structure Information 1h8b ACTN2 ef-hands 3,4 from alpha-actinin / z-repeat 7 from titin -1.0Å AUTH R.A.ATKINSON,C.JOSEPH,G.KELLY,F.W.MUSKETT,AUTH 2 T.A.FRENKIEL,D.NIETLISPACH,A.PASTORETITL CA2+-INDEPENDENT BINDING OF AN EF-HAND DOMAIN TO ATITL 2 NOVEL MOTIF IN THE ALPHA-ACTININ-TITIN COMPLEXREF NAT.STRUCT.BIOL. V. 8 853 2001REFN ISSN 1072-8368PMID 11573089DOI 10.1038/NSB1001-853 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2rnr GTF2H1 solution structure of the complex between tfiie alpha c- terminal acidic domain and tfiih p62 ph domain -1.0Å AUTH M.OKUDA,A.TANAKA,M.SATOH,S.MIZUTA,M.TAKAZAWA,AUTH 2 Y.OHKUMA,Y.NISHIMURATITL STRUCTURAL INSIGHT INTO THE TFIIE-TFIIHTITL 2 INTERACTION: TFIIE AND P53 SHARE THE BINDINGTITL 3 REGION ON TFIIHREF EMBO J. V. 27 1161 2008REFN ISSN 0261-4189PMID 18354501DOI 10.1038/EMBOJ.2008.47 Variant […]