Assessment of Structural Intolerance and Durability
General Structure Information 2a8h ADAM17 crystal structure of catalytic domain of tace with thiomorpholine sulfonamide hydroxamate inhibitor 2.3Å AUTH J.I.LEVIN,J.M.CHEN,L.M.LAAKSO,M.DU,J.SCHMID,W.XU,AUTH 2 T.CUMMONS,J.XU,G.JIN,D.BARONE,J.S.SKOTNICKITITL ACETYLENIC TACE INHIBITORS. PART 3: THIOMORPHOLINETITL 2 SULFONAMIDE HYDROXAMATES.REF BIOORG.MED.CHEM.LETT. V. 16 1605 2006REFN ISSN 0960-894XPMID 16426848DOI 10.1016/J.BMCL.2005.12.020 Variant Set Distributions Mapped Variants
General Structure Information 1hur ARF1 human adp-ribosylation factor 1 complexed with gdp, full length non-myristoylated 2.0Å AUTH J.C.AMOR,D.H.HARRISON,R.A.KAHN,D.RINGETITL STRUCTURE OF THE HUMAN ADP-RIBOSYLATION FACTOR 1TITL 2 COMPLEXED WITH GDP.REF NATURE V. 372 704 1994REFN ISSN 0028-0836PMID 7990966DOI 10.1038/372704A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1qkl POLR2F hrpabc14.4, essential subunit of human rna polymerases i, ii and iii -1.0Å AUTH F.DEL RIO-PORTILLA,A.G.GASKELL,D.GILBERT,AUTH 2 J.A.A.LADIAS,G.WAGNERTITL SOLUTION STRUCTURE OF THE HRPABC14.4 SUBUNIT OFTITL 2 HUMAN RNA POLYMERASESREF NAT.STRUCT.BIOL. V. 6 1039 1999REFN ISSN 1072-8368PMID 10542096DOI 10.1038/14923 Variant Set Distributions Mapped Variants
General Structure Information 1l8l PSPH molecular basis for the local confomational rearrangement of human phosphoserine phosphatase 2.51Å AUTH H.Y.KIM,Y.S.HEO,J.H.KIM,M.H.PARK,J.MOON,E.KIM,AUTH 2 D.KWON,J.YOON,D.SHIN,E.J.JEONG,S.Y.PARK,T.G.LEE,AUTH 3 Y.H.JEON,S.RO,J.M.CHO,K.Y.HWANGTITL MOLECULAR BASIS FOR THE LOCAL CONFORMATIONALTITL 2 REARRANGEMENT OF HUMAN PHOSPHOSERINE PHOSPHATASE.REF J.BIOL.CHEM. V. 277 46651 2002REFN ISSN 0021-9258PMID 12213811DOI 10.1074/JBC.M204866200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2br9 YWHAE 14-3-3 protein epsilon (human) complexed to peptide 1.75Å AUTH X.YANG,W.H.LEE,F.SOBOTT,E.PAPAGRIGORIOU,C.V.ROBINSON,AUTH 2 J.G.GROSSMANN,M.SUNDSTROM,D.A.DOYLE,J.M.ELKINSTITL STRUCTURAL BASIS FOR PROTEIN-PROTEIN INTERACTIONS IN THETITL 2 14-3-3 PROTEIN FAMILY.REF PROC.NATL.ACAD.SCI.USA V. 103 17237 2006REFN ISSN 0027-8424PMID 17085597DOI 10.1073/PNAS.0605779103 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3jts B2M gy9-mamu-a*02-hb2m 2.8Å AUTH L.DAITITL STRUCTURE OF MAMU A*2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4kfm GNB1 crystal structure of the g protein-gated inward rectifier k+ channel girk2 (kir3.2) in complex with the beta-gamma g protein subunits 3.45Å AUTH M.R.WHORTON,R.MACKINNONTITL X-RAY STRUCTURE OF THE MAMMALIAN GIRK2-BETA GAMMA G-PROTEINTITL 2 COMPLEX.REF NATURE V. 498 190 2013REFN ISSN 0028-0836PMID 23739333DOI 10.1038/NATURE12241 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4kfm GNG2 crystal structure of the g protein-gated inward rectifier k+ channel girk2 (kir3.2) in complex with the beta-gamma g protein subunits 3.45Å AUTH M.R.WHORTON,R.MACKINNONTITL X-RAY STRUCTURE OF THE MAMMALIAN GIRK2-BETA GAMMA G-PROTEINTITL 2 COMPLEX.REF NATURE V. 498 190 2013REFN ISSN 0028-0836PMID 23739333DOI 10.1038/NATURE12241 Variant Set Distributions Mapped Variants
General Structure Information 1vjb ESRRG crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with 4- hydroxytamoxifen 3.2Å AUTH H.GRESCHIK,R.FLAIG,J.P.RENAUD,D.MORASTITL STRUCTURAL BASIS FOR THE DEACTIVATION OF THETITL 2 ESTROGEN-RELATED RECEPTOR {GAMMA} BYTITL 3 DIETHYLSTILBESTROL OR 4-HYDROXYTAMOXIFEN ANDTITL 4 DETERMINANTS OF SELECTIVITY.REF J.BIOL.CHEM. V. 279 33639 2004REFN ISSN 0021-9258PMID 15161930DOI 10.1074/JBC.M402195200 Variant […]
General Structure Information 2wng SIRPA complete extracellular structure of human signal regulatory protein (sirp) alpha 2.49Å AUTH D.HATHERLEY,S.C.GRAHAM,K.HARLOS,D.I.STUART,AUTH 2 A.N.BARCLAYTITL STRUCTURE OF SIGNAL-REGULATORY PROTEIN ALPHA: ATITL 2 LINK TO ANTIGEN RECEPTOR EVOLUTION.REF J.BIOL.CHEM. V. 284 26613 2009REFN ISSN 0021-9258PMID 19628875DOI 10.1074/JBC.M109.017566 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]