Assessment of Structural Intolerance and Durability
General Structure Information 1dgn CARD18 solution structure of iceberg, an inhibitor of interleukin- 1beta generation -1.0Å AUTH E.W.HUMKE,S.K.SHRIVER,M.A.STAROVASNIK,AUTH 2 W.J.FAIRBROTHER,V.M.DIXITTITL ICEBERG: A NOVEL INHIBITOR OF INTERLEUKIN-1BETATITL 2 GENERATION.REF CELL(CAMBRIDGE,MASS.) V. 103 99 2000REFN ISSN 0092-8674PMID 11051551DOI 10.1016/S0092-8674(00)00108-2 Variant Set Distributions Mapped Variants
General Structure Information 3gd8 AQP4 crystal structure of human aquaporin 4 at 1.8 and its mechanism of conductance 1.8Å AUTH J.D.HO,R.YEH,A.SANDSTROM,I.CHORNY,W.E.HARRIES,R.A.ROBBINS,AUTH 2 L.J.MIERCKE,R.M.STROUDTITL CRYSTAL STRUCTURE OF HUMAN AQUAPORIN 4 AT 1.8 A AND ITSTITL 2 MECHANISM OF CONDUCTANCE.REF PROC.NATL.ACAD.SCI.USA V. 106 7437 2009REFN ISSN 0027-8424PMID 19383790DOI 10.1073/PNAS.0902725106 Variant Set Distributions Mapped Variants
General Structure Information 3nkx YWHAZ impaired binding of 14-3-3 to raf1 is linked to noonan and leopard syndrome 2.4Å AUTH M.MOLZAN,B.SCHUMACHER,C.OTTMANN,A.BALJULS,L.POLZIEN,AUTH 2 M.WEYAND,P.THIEL,R.ROSE,M.ROSE,P.KUHENNE,M.KAISER,U.R.RAPP,AUTH 3 J.KUHLMANN,C.OTTMANNTITL IMPAIRED BINDING OF 14-3-3 TO C-RAF IN NOONAN SYNDROMETITL 2 SUGGESTS NEW APPROACHES IN DISEASES WITH INCREASED RASTITL 3 SIGNALINGREF MOL.CELL.BIOL. V. 30 4698 2010REFN ISSN 0270-7306PMID 20679480DOI 10.1128/MCB.01636-09 Variant […]
General Structure Information 2vjf MDM2 crystal structure of the mdm2-mdmx ring domain heterodimer 2.3Å AUTH K.LINKE,P.D.MACE,C.A.SMITH,D.L.VAUX,J.SILKE,C.L.DAYTITL STRUCTURE OF THE MDM2/MDMX RING DOMAIN HETERODIMERTITL 2 REVEALS DIMERIZATION IS REQUIRED FOR THEIRTITL 3 UBIQUITYLATION IN TRANS.REF CELL DEATH DIFFER. V. 15 841 2008REFN ISSN 1350-9047PMID 18219319DOI 10.1038/SJ.CDD.4402309 Variant Set Distributions Mapped Variants
General Structure Information 1yg5 HBA2 t-to-t(high) quaternary transitions in human hemoglobin: betaw37h oxy (2mm ihp, 20% peg) (10 test sets) 2.7Å AUTH J.S.KAVANAUGH,P.H.ROGERS,A.ARNONETITL CRYSTALLOGRAPHIC EVIDENCE FOR A NEW ENSEMBLE OFTITL 2 LIGAND-INDUCED ALLOSTERIC TRANSITIONS INTITL 3 HEMOGLOBIN: THE T-TO-T(HIGH) QUATERNARYTITL 4 TRANSITIONS.REF BIOCHEMISTRY V. 44 6101 2005REFN ISSN 0006-2960PMID 15835899DOI 10.1021/BI047813A Variant Set Distributions Pathogenic […]
General Structure Information 1yg5 HBA1 t-to-t(high) quaternary transitions in human hemoglobin: betaw37h oxy (2mm ihp, 20% peg) (10 test sets) 2.7Å AUTH J.S.KAVANAUGH,P.H.ROGERS,A.ARNONETITL CRYSTALLOGRAPHIC EVIDENCE FOR A NEW ENSEMBLE OFTITL 2 LIGAND-INDUCED ALLOSTERIC TRANSITIONS INTITL 3 HEMOGLOBIN: THE T-TO-T(HIGH) QUATERNARYTITL 4 TRANSITIONS.REF BIOCHEMISTRY V. 44 6101 2005REFN ISSN 0006-2960PMID 15835899DOI 10.1021/BI047813A Variant Set Distributions Pathogenic […]
General Structure Information 1pq6 NR1H2 human lxr beta hormone receptor / gw3965 complex 2.4Å AUTH M.FARNEGARDH,T.BONN,S.SUN,J.LJUNGGREN,H.AHOLA,A.WILHELMSSON,AUTH 2 J.-A.GUSTAFSSON,M.CARLQUISTTITL THE THREE-DIMENSIONAL STRUCTURE OF THE LIVER X RECEPTOR BETATITL 2 REVEALS A FLEXIBLE LIGAND-BINDING POCKET THAT CANTITL 3 ACCOMMODATE FUNDAMENTALLY DIFFERENT LIGANDS.REF J.BIOL.CHEM. V. 278 38821 2003REFN ISSN 0021-9258PMID 12819202DOI 10.1074/JBC.M304842200 Variant Set Distributions Mapped Variants
General Structure Information 1z0a RAB2A gdp-bound rab2a gtpase 2.12Å AUTH S.EATHIRAJ,X.PAN,C.RITACCO,D.G.LAMBRIGHTTITL STRUCTURAL BASIS OF FAMILY-WIDE RAB GTPASETITL 2 RECOGNITION BY RABENOSYN-5.REF NATURE V. 436 415 2005REFN ISSN 0028-0836PMID 16034420DOI 10.1038/NATURE03798 Variant Set Distributions Mapped Variants
General Structure Information 4bw5 KCNK10 crystal structure of human two pore domain potassium ion channel trek2 (k2p10.1) 3.4Å AUTH A.C.W.PIKE,A.MACKENZIE,C.MCCLENAGHAN,P.ARYAL,L.DONG,AUTH 2 A.QUIGLEY,M.GRIEBEN,S.GOUBIN,S.MUKHOPADHYAY,G.F.RUDA,AUTH 3 M.V.CLAUSEN,L.CAO,P.E.BRENNAN,N.A.BURGESS-BROWN,AUTH 4 M.S.P.SANSOM,S.J.TUCKER,E.P.CARPENTERTITL K2P CHANNEL GATING MECHANISMS REVEALED BY STRUCTURES OFTITL 2 TREK-2 AND A COMPLEX WITH PROZACREF SCIENCE V. 347 1256 2015REFN ISSN 0036-8075PMID 25766236DOI 10.1126/SCIENCE.1261512 Variant Set Distributions Ripley’s K […]
General Structure Information 3v3k CASP9 human caspase 9 in complex with bacterial effector protein 3.49Å AUTH M.MOERTL,K.MASKOS,H.STEUBERTITL HUMAN CASPASE 9 IN COMPLEX WITH BACTERIAL EFFECTOR PROTEINREF PLOS ONE 2013REFN ESSN 1932-6203 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants