Assessment of Structural Intolerance and Durability
General Structure Information 1x2p PRMT2 solution structure of the sh3 domain of the protein arginine n-methyltransferase 2 -1.0Å AUTH E.CHIKAYAMA,T.KIGAWA,K.SAITO,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF THETITL 2 PROTEIN ARGININE N-METHYLTRANSFERASE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2tgi TGFB2 crystal structure of transforming growth factor-beta2: an unusual fold for the superfamily 1.8Å AUTH S.DAOPIN,K.A.PIEZ,Y.OGAWA,D.R.DAVIESTITL CRYSTAL STRUCTURE OF TRANSFORMING GROWTH FACTOR-BETA 2: ANTITL 2 UNUSUAL FOLD FOR THE SUPERFAMILY.REF SCIENCE V. 257 369 1992REFN ISSN 0036-8075PMID 1631557 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1×44 MYBPC1 solution structure of the third ig-like domain of myosin- dinding protein c, slow-type -1.0Å AUTH X.-R.QIN,C.KUROSAKI,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD IG-LIKE DOMAIN OFTITL 2 MYOSIN-DINDING PROTEIN C, SLOW-TYPEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1gy5 NUTF2 d92n,d94n double point mutant of human nuclear transport factor 2 (ntf2) 2.3Å AUTH R.BAYLISS,S.LEUNG,R.BAKER,B.QUIMBY,A.CORBETT,AUTH 2 M.STEWARTTITL STRUCTURAL BASIS FOR THE INTERACTION BETWEEN NTF2TITL 2 AND NUCLEOPORIN FXFG REPEATSREF EMBO J. V. 21 2843 2002REFN ISSN 0261-4189PMID 12065398DOI 10.1093/EMBOJ/CDF305 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2z5d UBE2H human ubiquitin-conjugating enzyme e2 h 2.1Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL.CELL PROTEOMICS V. 11 329 2012REFN ISSN 1535-9476PMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants
General Structure Information 4ie2 ARG2 crystal structure of human arginase-2 complexed with inhibitor 1h 2.21Å AUTH A.GOLEBIOWSKI,R.PAUL BECKETT,M.VAN ZANDT,M.K.JI,AUTH 2 D.WHITEHOUSE,T.R.RYDER,E.JAGDMANN,M.ANDREOLI,A.MAZUR,AUTH 3 M.PADMANILAYAM,A.COUSIDO-SIAH,A.MITSCHLER,F.X.RUIZ,AUTH 4 A.PODJARNY,H.SCHROETERTITL 2-SUBSTITUTED-2-AMINO-6-BORONOHEXANOIC ACIDS AS ARGINASETITL 2 INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 23 2027 2013REFN ISSN 0960-894XPMID 23453840DOI 10.1016/J.BMCL.2013.02.024 Variant Set Distributions Mapped Variants
General Structure Information 2xeu RNF4 ring domain 1.5Å AUTH A.PLECHANOVOVA,E.G.JAFFRAY,S.A.MCMAHON,K.A.JOHNSON,AUTH 2 I.NAVRATILOVA,J.H.NAISMITH,R.T.HAYTITL MECHANISM OF UBIQUITYLATION BY DIMERIC RING LIGASE RNF4REF NAT.STRUCT.MOL.BIOL. V. 18 1052 2011REFN ISSN 1545-9993PMID 21857666DOI 10.1038/NSMB.2108 Variant Set Distributions Mapped Variants
General Structure Information 2lxp UBE2G2 nmr structure of two domains in ubiquitin ligase gp78, ring and g2br, bound to its conjugating enzyme ube2g -1.0Å AUTH R.DAS,Y.H.LIANG,J.MARIANO,J.LI,T.HUANG,A.KING,S.G.TARASOV,AUTH 2 A.M.WEISSMAN,X.JI,R.A.BYRDTITL ALLOSTERIC REGULATION OF E2:E3 INTERACTIONS PROMOTE ATITL 2 PROCESSIVE UBIQUITINATION MACHINE.REF EMBO J. V. 32 2504 2013REFN ISSN 0261-4189PMID 23942235DOI 10.1038/EMBOJ.2013.174 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2djn DLX5 the solution structure of the homeobox domain of human homeobox protein dlx-5 -1.0Å AUTH A.SASAGAWA,S.OHNISHI,N.TOCHIO,K.SAITO,S.KOSHIBA,AUTH 2 M.INOUE,T.KIGAWA,S.YOKOYAMATITL THE SOLUTION STRUCTURE OF THE HOMEOBOX DOMAIN OFTITL 2 HUMAN HOMEOBOX PROTEIN DLX-5REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dav MYBPC1 solution structure of the first ig-like domain of myosin- binding protein c, slow-type -1.0Å AUTH X.R.QIN,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST IG-LIKE DOMAIN OFTITL 2 MYOSIN-BINDING PROTEIN C, SLOW-TYPEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants