Assessment of Structural Intolerance and Durability
General Structure Information 2m2f ADAM17 the membran-proximal domain of adam17 -1.0Å AUTH S.DUSTERHOFT,S.JUNG,C.W.HUNG,A.THOLEY,F.D.SONNICHSEN,AUTH 2 J.GROTZINGER,I.LORENZENTITL MEMBRANE-PROXIMAL DOMAIN OF A DISINTEGRIN ANDTITL 2 METALLOPROTEASE-17 REPRESENTS THE PUTATIVE MOLECULAR SWITCHTITL 3 OF ITS SHEDDING ACTIVITY OPERATED BY PROTEIN-DISULFIDETITL 4 ISOMERASE.REF J.AM.CHEM.SOC. V. 135 5776 2013REFN ISSN 0002-7863PMID 23521534DOI 10.1021/JA400340U Variant Set Distributions Mapped Variants
General Structure Information 3hu2 VCP structure of p97 n-d1 r86a mutant in complex with atpgs 2.85Å AUTH W.K.TANG,D.LI,C.C.LI,L.ESSER,R.DAI,L.GUO,D.XIATITL A NOVEL ATP-DEPENDENT CONFORMATION IN P97 N-D1 FRAGMENTTITL 2 REVEALED BY CRYSTAL STRUCTURES OF DISEASE-RELATED MUTANTS.REF EMBO J. V. 29 2217 2010REFN ISSN 0261-4189PMID 20512113DOI 10.1038/EMBOJ.2010.104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2cte HDLBP solution structure of the 1st kh type i domain from human vigilin -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 1ST KH TYPE I DOMAINTITL 2 FROM HUMAN VIGILINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3i4w DLG4 crystal structure of the third pdz domain of psd-95 1.35Å AUTH A.CAMARA-ARTIGAS,J.MURCIANO-CALLES,J.A.GAVIRA,E.S.COBOS,AUTH 2 J.C.MARTINEZTITL NOVEL CONFORMATIONAL ASPECTS OF THE THIRD PDZ DOMAIN OF THETITL 2 NEURONAL POST-SYNAPTIC DENSITY-95 PROTEIN REVEALED FROM TWOTITL 3 1.4A X-RAY STRUCTURESREF J.STRUCT.BIOL. V. 170 565 2010REFN ISSN 1047-8477PMID 20227506DOI 10.1016/J.JSB.2010.03.005 Variant Set Distributions Mapped Variants
General Structure Information 3ygs CASP9 apaf-1 card in complex with prodomain of procaspase-9 2.5Å AUTH H.QIN,S.M.SRINIVASULA,G.WU,T.FERNANDES-ALNEMRI,AUTH 2 E.S.ALNEMRI,Y.SHITITL STRUCTURAL BASIS OF PROCASPASE-9 RECRUITMENT BYTITL 2 THE APOPTOTIC PROTEASE-ACTIVATING FACTOR 1.REF NATURE V. 399 549 1999REFN ISSN 0028-0836PMID 10376594DOI 10.1038/21124 Variant Set Distributions Mapped Variants
General Structure Information 2wcb S100A12 s100a12 complex with zinc in the absence of calcium 1.73Å AUTH O.V.MOROZ,E.V.BLAGOVA,A.J.WILKINSON,K.S.WILSON,I.B.BRONSTEINTITL THE CRYSTAL STRUCTURES OF HUMAN S100A12 IN APO FORM AND INTITL 2 COMPLEX WITH ZINC: NEW INSIGHTS INTO S100A12TITL 3 OLIGOMERISATION.REF J.MOL.BIOL. V. 391 536 2009REFN ISSN 0022-2836PMID 19501594DOI 10.1016/J.JMB.2009.06.004 Variant Set Distributions Mapped Variants
General Structure Information 2ihd RGS8 crystal structure of human regulator of g-protein signaling 8, rgs8 1.7Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1mhd SMAD3 crystal structure of a smad mh1 domain bound to dna 2.8Å AUTH Y.SHI,Y.F.WANG,L.JAYARAMAN,H.YANG,J.MASSAGUE,AUTH 2 N.P.PAVLETICHTITL CRYSTAL STRUCTURE OF A SMAD MH1 DOMAIN BOUND TOTITL 2 DNA: INSIGHTS ON DNA BINDING IN TGF-BETA SIGNALING.REF CELL(CAMBRIDGE,MASS.) V. 94 585 1998REFN ISSN 0092-8674PMID 9741623DOI 10.1016/S0092-8674(00)81600-1 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1×50 LGALS4 solution structure of the c-terminal gal-bind lectin domain from human galectin-4 -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,K.SAITO,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C-TERMINAL GAL-BINDTITL 2 LECTIN DOMAIN FROM HUMAN GALECTIN-4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3bpn IL13RA1 crystal structure of the il4-il4r-il13ra ternary complex 3.02Å AUTH S.L.LAPORTE,Z.S.JUO,J.VACLAVIKOVA,L.A.COLF,X.QI,N.M.HELLER,AUTH 2 A.D.KEEGAN,K.C.GARCIATITL MOLECULAR AND STRUCTURAL BASIS OF CYTOKINE RECEPTORTITL 2 PLEIOTROPY IN THE INTERLEUKIN-4/13 SYSTEM.REF CELL(CAMBRIDGE,MASS.) V. 132 259 2008REFN ISSN 0092-8674PMID 18243101DOI 10.1016/J.CELL.2007.12.030 Variant Set Distributions Mapped Variants