Assessment of Structural Intolerance and Durability
General Structure Information 2ery RRAS2 the crystal structure of the ras related protein rras2 (rras2) in the gdp bound state 1.7Å AUTH E.SALAH,G.SCHOCH,A.TURNBULL,E.PAPAGRIGORIOU,M.SOUNDARARAJAN,AUTH 2 N.BURGESS,J.ELKINS,C.GILEADI,O.GILEADI,F.VON DELFT,AUTH 3 A.EDWARDS,C.ARROWSMITH,J.WEIGELT,M.SUNDSTROM,D.DOYLETITL THE CRYSTAL STRUCTURE OF THE RAS RELATED PROTEIN RRAS2TITL 2 (RRAS2) IN THE GDP BOUND STATEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1unl CDK5 structural mechanism for the inhibition of cd5-p25 from the roscovitine, aloisine and indirubin. 2.2Å AUTH M.MAPELLI,L.MASSIMILINAO,C.CROVACE,M.A.SEELIGER,L.-H.TSAI,AUTH 2 L.MEIJER,A.MUSACCHIOTITL MECHANISM OF CDK5/P25 BINDING BY CDK INHIBITORSREF J.MED.CHEM. V. 48 671 2005REFN ISSN 0022-2623PMID 15689152DOI 10.1021/JM049323M Variant Set Distributions Mapped Variants
General Structure Information 2hf6 COPZ1 solution structure of human zeta-cop -1.0Å AUTH W.YU,J.LIN,C.JIN,B.XIATITL SOLUTION STRUCTURE OF HUMAN ZETA-COP: DIRECT EVIDENCES FORTITL 2 STRUCTURAL SIMILARITY BETWEEN COP I AND CLATHRIN-ADAPTORTITL 3 COATSREF J.MOL.BIOL. V. 386 903 2009REFN ISSN 0022-2836PMID 19167404DOI 10.1016/J.JMB.2008.12.083 Variant Set Distributions Mapped Variants
General Structure Information 4aow GNB2L1 crystal structure of the human rack1 protein at a resolution of 2.45 angstrom 2.45Å AUTH D.RUIZ CARRILLO,R.CHANDRASEKARAN,M.NILSSON,T.CORNVIK,AUTH 2 C.W.LIEW,S.M.TAN,J.LESCARTITL STRUCTURE OF HUMAN RACK1 PROTEIN AT A RESOLUTION OF 2.45 A.REF ACTA CRYSTALLOGR.,SECT.F V. 68 867 2012REFN ISSN 1744-3091PMID 22869111DOI 10.1107/S1744309112027480 Variant Set Distributions Mapped Variants
General Structure Information 1w50 BACE1 apo structure of bace (beta secretase) 1.75Å AUTH S.PATEL,L.VUILLARD,A.CLEASBY,C.W.MURRAY,J.YONTITL APO AND INHIBITOR COMPLEX STRUCTURES OF BACETITL 2 (BETA-SECRETASE)REF J.MOL.BIOL. V. 343 407 2004REFN ISSN 0022-2836PMID 15451669DOI 10.1016/J.JMB.2004.08.018 Variant Set Distributions Mapped Variants
General Structure Information 4iyp IGBP1 structure of the npp2ac-alpha4 complex 2.8Å AUTH L.JIANG,V.STANEVICH,K.A.SATYSHUR,M.KONG,G.R.WATKINS,AUTH 2 B.E.WADZINSKI,R.SENGUPTA,Y.XINGTITL STRUCTURAL BASIS OF PROTEIN PHOSPHATASE 2A STABLE LATENCY.REF NAT COMMUN V. 4 1699 2013REFN ESSN 2041-1723PMID 23591866DOI 10.1038/NCOMMS2663 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4f52 RBX1 structure of a glomulin-rbx1-cul1 complex 3.0Å AUTH D.M.DUDA,J.L.OLSZEWSKI,A.E.TRON,M.HAMMEL,L.J.LAMBERT,AUTH 2 M.B.WADDELL,T.MITTAG,J.A.DECAPRIO,B.A.SCHULMANTITL STRUCTURE OF A GLOMULIN-RBX1-CUL1 COMPLEX: INHIBITION OF ATITL 2 RING E3 LIGASE THROUGH MASKING OF ITS E2-BINDING SURFACE.REF MOL.CELL V. 47 371 2012REFN ISSN 1097-2765PMID 22748924DOI 10.1016/J.MOLCEL.2012.05.044 Variant Set Distributions Mapped Variants
General Structure Information 3d9s AQP5 human aquaporin 5 (aqp5) – high resolution x-ray structure 2.0Å AUTH R.HORSEFIELD,K.NORDEN,M.FELLERT,A.BACKMARK,AUTH 2 S.TORNROTH-HORSEFIELD,AUTH 3 A.C.TERWISSCHA VAN SCHELTINGA,J.KVASSMAN,AUTH 4 P.KJELLBOM,U.JOHANSON,R.NEUTZETITL HIGH-RESOLUTION X-RAY STRUCTURE OF HUMAN AQUAPORINTITL 2 5REF PROC.NATL.ACAD.SCI.USA V. 105 13327 2008REFN ISSN 0027-8424PMID 18768791DOI 10.1073/PNAS.0801466105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1hp8 CMC4 solution structure of human p8-mtcp1, a cysteine-rich protein encoded by the mtcp1 oncogene,reveals a new alpha- helical assembly motif, nmr, minimized average structure -1.0Å AUTH P.BARTHE,Y.S.YANG,L.CHICHE,F.HOH,M.P.STRUB,AUTH 2 L.GUIGNARD,J.SOULIER,M.H.STERN,H.VAN TILBEURGH,AUTH 3 J.M.LHOSTE,C.ROUMESTANDTITL SOLUTION STRUCTURE OF HUMAN P8MTCP1, ATITL 2 CYSTEINE-RICH PROTEIN ENCODED BY THE MTCP1TITL 3 ONCOGENE, REVEALS A NEW ALPHA-HELICAL […]
General Structure Information 3crd CRADD nmr structure of the raidd card domain, 15 structures -1.0Å AUTH J.J.CHOU,H.MATSUO,H.DUAN,G.WAGNERTITL SOLUTION STRUCTURE OF THE RAIDD CARD AND MODEL FORTITL 2 CARD/CARD INTERACTION IN CASPASE-2 AND CASPASE-9TITL 3 RECRUITMENT.REF CELL(CAMBRIDGE,MASS.) V. 94 171 1998REFN ISSN 0092-8674PMID 9695946DOI 10.1016/S0092-8674(00)81417-8 Variant Set Distributions Mapped Variants