Assessment of Structural Intolerance and Durability
General Structure Information 1vol GTF2B tfiib (human core domain)/tbp (a.thaliana)/tata element ternary complex 2.7Å AUTH D.B.NIKOLOV,H.CHEN,E.D.HALAY,A.A.USHEVA,K.HISATAKE,AUTH 2 D.K.LEE,R.G.ROEDER,S.K.BURLEYTITL CRYSTAL STRUCTURE OF A TFIIB-TBP-TATA-ELEMENTTITL 2 TERNARY COMPLEX.REF NATURE V. 377 119 1995REFN ISSN 0028-0836PMID 7675079DOI 10.1038/377119A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3sf4 GPSM2 crystal structure of the complex between the conserved cell polarity proteins inscuteable and lgn 2.6Å AUTH S.YUZAWA,S.KAMAKURA,Y.IWAKIRI,J.HAYASE,H.SUMIMOTOTITL STRUCTURAL BASIS FOR INTERACTION BETWEEN THE CONSERVED CELLTITL 2 POLARITY PROTEINS INSCUTEABLE AND LEU-GLY-ASNTITL 3 REPEAT-ENRICHED PROTEIN (LGN)REF PROC.NATL.ACAD.SCI.USA V. 108 19210 2011REFN ISSN 0027-8424PMID 22074847DOI 10.1073/PNAS.1110951108 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1jsg TCL1A crystal structure of p14tcl1, an oncogene product involved in t-cell prolymphocytic leukemia, reveals a novel b- barrel topology 2.5Å AUTH F.HOH,Y.S.YANG,L.GUIGNARD,A.PADILLA,M.H.STERN,AUTH 2 J.M.LHOSTE,H.VAN TILBEURGHTITL CRYSTAL STRUCTURE OF P14TCL1, AN ONCOGENE PRODUCTTITL 2 INVOLVED IN T-CELL PROLYMPHOCYTIC LEUKEMIA,TITL 3 REVEALS A NOVEL BETA-BARREL TOPOLOGY.REF STRUCTURE V. 6 147 1998REFN ISSN 0969-2126PMID […]
General Structure Information 4js0 CDC42 complex of cdc42 with the crib-pr domain of irsp53 1.9Å AUTH D.J.KAST,C.YANG,A.DISANZA,M.BOCZKOWSKA,Y.MADASU,G.SCITA,AUTH 2 T.SVITKINA,R.DOMINGUEZTITL MECHANISM OF IRSP53 INHIBITION AND COMBINATORIAL ACTIVATIONTITL 2 BY CDC42 AND DOWNSTREAM EFFECTORS.REF NAT.STRUCT.MOL.BIOL. V. 21 413 2014REFN ISSN 1545-9993PMID 24584464DOI 10.1038/NSMB.2781 Variant Set Distributions Mapped Variants
General Structure Information 1o7b TNFAIP6 refined solution structure of the human tsg-6 link module -1.0Å AUTH C.D.BLUNDELL,D.MAHONEY,A.ALMOND,P.DEANGELIS,AUTH 2 J.D.KAHMANN,P.TERIETE,A.R.PICKFORD,I.D.CAMPBELL,AUTH 3 A.J.DAYTITL THE LINK MODULE FROM OVULATION- ANDTITL 2 INFLAMMATION-ASSOCIATED PROTEIN TSG-6 CHANGESTITL 3 CONFORMATION ON HYALURONAN BINDINGREF J.BIOL.CHEM. V. 278 49261 2003REFN ISSN 0021-9258PMID 12972412DOI 10.1074/JBC.M309623200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2nlw EIF3B solution structure of the rrm domain of human eukaryotic initiation factor 3b -1.0Å AUTH L.ELANTAK,A.G.TZAKOS,N.LOCKER,P.J.LUKAVSKYTITL STRUCTURE OF EIF3B RNA RECOGNITION MOTIF AND ITSTITL 2 INTERACTION WITH EIF3J: STRUCTURAL INSIGHTS INTOTITL 3 THE RECRUITMENT OF EIF3B TO THE 40 S RIBOSOMALTITL 4 SUBUNIT.REF J.BIOL.CHEM. V. 282 8165 2007REFN ISSN 0021-9258PMID 17190833DOI […]
General Structure Information 1pl6 SORD human sdh/nadh/inhibitor complex 2.0Å AUTH T.A.PAULY,J.L.EKSTROM,D.A.BEEBE,B.CHRUNYK,D.CUNNINGHAM,AUTH 2 M.GRIFFOR,A.KAMATH,S.E.LEE,R.MADURA,D.MCGUIRE,T.SUBASHI,AUTH 3 D.WASILKO,P.WATTS,B.L.MYLARI,P.J.OATES,P.D.ADAMS,V.L.RATHTITL X-RAY CRYSTALLOGRAPHIC AND KINETIC STUDIES OF HUMAN SORBITOLTITL 2 DEHYDROGENASE.REF STRUCTURE V. 11 1071 2003REFN ISSN 0969-2126PMID 12962626DOI 10.1016/S0969-2126(03)00167-9 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ht6 GEM crystal structure of human gem g-domain bound to gdp 2.4Å AUTH Y.OPATOWSKY,Y.SASSON,I.SHAKED,Y.WARD,AUTH 2 O.CHOMSKY-HECHT,Y.LITVAK,Z.SELINGER,K.KELLY,AUTH 3 J.A.HIRSCHTITL STRUCTURE-FUNCTION STUDIES OF THE G-DOMAIN FROMTITL 2 HUMAN GEM, A NOVEL SMALL G-PROTEIN.REF FEBS LETT. V. 580 5959 2006REFN ISSN 0014-5793PMID 17052716DOI 10.1016/J.FEBSLET.2006.09.067 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4dgj TMPRSS15 structure of a human enteropeptidase light chain variant 1.9Å AUTH P.SIMEONOV,M.ZAHN,N.STRATER,T.ZUCHNERTITL CRYSTAL STRUCTURE OF A SUPERCHARGED VARIANT OF THE HUMANTITL 2 ENTEROPEPTIDASE LIGHT CHAIN.REF PROTEINS V. 80 1907 2012REFN ISSN 0887-3585PMID 22488687DOI 10.1002/PROT.24084 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3u9c CSNK2A1 structure of a c-terminal deletion mutant of human protein kinase ck2 catalytic subunit with the atp-competitive inhibitor resorufin 3.2Å AUTH K.KLOPFFLEISCH,O.G.ISSINGER,K.NIEFINDTITL LOW-DENSITY CRYSTAL PACKING OF HUMAN PROTEIN KINASE CK2TITL 2 CATALYTIC SUBUNIT IN COMPLEX WITH RESORUFIN OR OTHERTITL 3 LIGANDS: A TOOL TO STUDY THE UNIQUE HINGE-REGION PLASTICITYTITL 4 OF […]