Assessment of Structural Intolerance and Durability
General Structure Information 3s6n GEMIN2 crystal structure of the gemin2-binding domain of smn, gemin2 in complex with smd1/d2/f/e/g from human 2.5Å AUTH R.ZHANG,B.R.SO,P.LI,J.YONG,T.GLISOVIC,L.WAN,G.DREYFUSSTITL STRUCTURE OF A KEY INTERMEDIATE OF THE SMN COMPLEX REVEALSTITL 2 GEMIN2S CRUCIAL FUNCTION IN SNRNP ASSEMBLY.REF CELL(CAMBRIDGE,MASS.) V. 146 384 2011REFN ISSN 0092-8674PMID 21816274DOI 10.1016/J.CELL.2011.06.043 Variant Set Distributions Mapped Variants
General Structure Information 4gqb PRMT5 crystal structure of the human prmt5:mep50 complex 2.06Å AUTH S.ANTONYSAMY,Z.BONDAY,R.M.CAMPBELL,B.DOYLE,Z.DRUZINA,AUTH 2 T.GHEYI,B.HAN,L.N.JUNGHEIM,Y.QIAN,C.RAUCH,M.RUSSELL,AUTH 3 J.M.SAUDER,S.R.WASSERMAN,K.WEICHERT,F.S.WILLARD,A.ZHANG,AUTH 4 S.EMTAGETITL CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 109 17960 2012REFN ISSN 0027-8424PMID 23071334DOI 10.1073/PNAS.1209814109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3fdl BCL2L11 bim bh3 peptide in complex with bcl-xl 1.78Å AUTH E.F.LEE,J.D.SADOWSKY,B.J.SMITH,P.E.CZABOTAR,AUTH 2 K.J.PETERSON-KAUFMAN,P.M.COLMAN,S.H.GELLMAN,AUTH 3 W.D.FAIRLIETITL HIGH-RESOLUTION STRUCTURAL CHARACTERIZATION OF ATITL 2 HELICAL ALPHA/BETA-PEPTIDE FOLDAMER BOUND TO THETITL 3 ANTI-APOPTOTIC PROTEIN BCL-X(L)REF ANGEW.CHEM.INT.ED.ENGL. V. 48 4318 2009REFN ISSN 1433-7851PMID 19229915DOI 10.1002/ANIE.200805761 Variant Set Distributions Mapped Variants
General Structure Information 3avr KDM6A catalytic fragment of utx/kdm6a bound with histone h3k27me3 peptide, n-oxyalylglycine, and ni(ii) 1.8Å AUTH T.SENGOKU,S.YOKOYAMATITL STRUCTURAL BASIS FOR HISTONE H3 LYS 27 DEMETHYLATION BYTITL 2 UTX/KDM6AREF GENES DEV. V. 25 2266 2011REFN ISSN 0890-9369PMID 22002947DOI 10.1101/GAD.172296.111 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1ehw NME4 human nucleoside diphosphate kinase 4 2.4Å AUTH L.MILON,P.MEYER,M.CHIADMI,A.MUNIER,M.JOHANSSON,A.KARLSSON,AUTH 2 I.LASCU,J.CAPEAU,J.JANIN,M.L.LACOMBETITL THE HUMAN NM23-H4 GENE PRODUCT IS A MITOCHONDRIAL NUCLEOSIDETITL 2 DIPHOSPHATE KINASE.REF J.BIOL.CHEM. V. 275 14264 2000REFN ISSN 0021-9258PMID 10799505DOI 10.1074/JBC.275.19.14264 Variant Set Distributions Mapped Variants
General Structure Information 2crp RGS5 solution structure of the rgs domain of regulator of g- protein signalling 5 (rgs 5) -1.0Å AUTH H.P.ZHANG,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RGS DOMAIN OF REGULATORTITL 2 OF G-PROTEIN SIGNALLING 5 (RGS 5)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2c0j TRAPPC3 crystal structure of the bet3-trs33 heterodimer 2.2Å AUTH M.-S.KIM,M.-J.YI,K.-H.LEE,J.WAGNER,C.MUNGER,Y.-G.KIM,AUTH 2 M.WHITEWAY,M.CYGLER,B.-H.OH,M.SACHERTITL BIOCHEMICAL AND CRYSTALLOGRAPHIC STUDIES REVEAL A SPECIFICTITL 2 INTERACTION BETWEEN TRAPP SUBUNITS TRS33P AND BET3PREF TRAFFIC V. 6 1183 2005REFN ISSN 1398-9219PMID 16262728DOI 10.1111/J.1600-0854.2005.00352.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3l4v MGAM crystal complex of n-terminal human maltase-glucoamylase with kotalanol 2.1Å AUTH L.SIM,K.JAYAKANTHAN,S.MOHAN,R.NASI,B.D.JOHNSTON,AUTH 2 B.M.PINTO,D.R.ROSETITL NEW GLUCOSIDASE INHIBITORS FROM AN AYURVEDIC HERBALTITL 2 TREATMENT FOR TYPE 2 DIABETES: STRUCTURES ANDTITL 3 INHIBITION OF HUMAN INTESTINAL MALTASE-GLUCOAMYLASETITL 4 WITH COMPOUNDS FROM SALACIA RETICULATA.REF BIOCHEMISTRY V. 49 443 2010REFN ISSN 0006-2960PMID 20039683DOI 10.1021/BI9016457 Variant […]
General Structure Information 3top MGAM crystral structure of the c-terminal subunit of human maltase- glucoamylase in complex with acarbose 2.88Å AUTH L.M.REN,X.H.QIN,X.F.CAO,L.L.WANG,F.BAI,G.BAI,Y.SHENTITL STRUCTURAL INSIGHT INTO SUBSTRATE SPECIFICITY OF HUMANTITL 2 INTESTINAL MALTASE-GLUCOAMYLASEREF PROTEIN CELL V. 2 827 2011REFN ISSN 1674-800XPMID 22058037DOI 10.1007/S13238-011-1105-3 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1z3s ANGPT2 angiopoietin-2 receptor binding domain 2.35Å AUTH W.A.BARTON,D.TZVETKOVA,D.B.NIKOLOVTITL STRUCTURE OF THE ANGIOPOIETIN-2 RECEPTOR BINDINGTITL 2 DOMAIN AND IDENTIFICATION OF SURFACES INVOLVED INTITL 3 TIE2 RECOGNITION.REF STRUCTURE V. 13 825 2005REFN ISSN 0969-2126PMID 15893672DOI 10.1016/J.STR.2005.03.009 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants