Assessment of Structural Intolerance and Durability
General Structure Information 4e71 PLXNB2 crystal structure of the rho gtpase binding domain of plexin b2 2.26Å AUTH X.GUAN,H.WANG,W.TEMPEL,Y.TONG,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF THE RHO GTPASE BINDING DOMAIN OF PLEXINTITL 2 B2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2a66 NR5A2 human liver receptor homologue dna-binding domain (hlrh-1 dbd) in complex with dsdna from the hcyp7a1 promoter 2.2Å AUTH I.H.SOLOMON,J.M.HAGER,R.SAFI,D.P.MCDONNELL,AUTH 2 M.R.REDINBO,E.A.ORTLUNDTITL CRYSTAL STRUCTURE OF THE HUMAN LRH-1 DBD-DNATITL 2 COMPLEX REVEALS FTZ-F1 DOMAIN POSITIONING ISTITL 3 REQUIRED FOR RECEPTOR ACTIVITY.REF J.MOL.BIOL. V. 354 1091 2005REFN ISSN 0022-2836PMID 16289203DOI 10.1016/J.JMB.2005.10.009 Variant […]
General Structure Information 1jjx FABP7 solution structure of recombinant human brain-type fatty acid binding protein -1.0Å AUTH M.RADEMACHER,A.W.ZIMMERMAN,H.RUTERJANS,AUTH 2 J.H.VEERKAMP,C.LUCKETITL SOLUTION STRUCTURE OF FATTY ACID-BINDING PROTEINTITL 2 FROM HUMAN BRAIN.REF MOL.CELL.BIOCHEM. V. 239 61 2002REFN ISSN 0300-8177PMID 12479569DOI 10.1023/A:1020566909213 Variant Set Distributions Mapped Variants
General Structure Information 2xue KDM6B crystal structure of jmjd3 2.0Å AUTH L.KRUIDENIER,C.CHUNG,Z.CHENG,J.LIDDLE,K.CHE,G.JOBERTY,AUTH 2 M.BANTSCHEFF,C.BOUNTRA,A.BRIDGES,H.DIALLO,D.EBERHARD,AUTH 3 S.HUTCHINSON,E.JONES,R.KATSO,M.LEVERIDGE,P.K.MANDER,AUTH 4 J.MOSLEY,C.RAMIREZ-MOLINA,P.ROWLAND,C.J.SCHOFIELD,AUTH 5 R.J.SHEPPARD,J.E.SMITH,C.SWALES,R.TANNER,P.THOMAS,A.TUMBER,AUTH 6 G.DREWES,U.OPPERMANN,D.J.PATEL,K.LEE,D.M.WILSONTITL A SELECTIVE JUMONJI H3K27 DEMETHYLASE INHIBITOR MODULATESTITL 2 THE PROINFLAMMATORY MACROPHAGE RESPONSEREF NATURE V. 488 404 2012REFN ISSN 0028-0836PMID 22842901DOI 10.1038/NATURE11262 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1n3c OGG1 structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase 2.7Å AUTH D.P.NORMAN,S.J.CHUNG,G.L.VERDINETITL STRUCTURAL AND BIOCHEMICAL EXPLORATION OF ATITL 2 CRITICAL AMINO ACID IN HUMAN 8-OXOGUANINETITL 3 GLYCOSYLASEREF BIOCHEMISTRY V. 42 1564 2003REFN ISSN 0006-2960PMID 12578369DOI 10.1021/BI026823D Variant Set Distributions Mapped Variants
General Structure Information 3epp RNMT crystal structure of mrna cap guanine-n7 methyltransferase (rnmt) in complex with sinefungin 2.41Å AUTH H.ZENG,M.F.AMAYA,P.LOPPNAU,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOTCHKAREV,J.MIN,A.N.PLOTNIKOV,AUTH 3 H.WUTITL CRYSTAL STRUCTURE OF MRNA CAP GUANINE-N7 METHYLTRANSFERASETITL 2 (RNMT) IN COMPLEX WITH SINEFUNGIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1rjt CXCL11 nmr structure of cxc chemokine cxcl11/itac -1.0Å AUTH V.BOOTH,I.CLARK-LEWIS,B.D.SYKESTITL NMR STRUCTURE OF CXCR3 BINDING CHEMOKINE CXCL11TITL 2 (ITAC).REF PROTEIN SCI. V. 13 2022 2004REFN ISSN 0961-8368PMID 15273303DOI 10.1110/PS.04791404 Variant Set Distributions Mapped Variants
General Structure Information 4h10 CLOCK intermolecular recognition revealed by the complex structure of human clock-bmal1 basic helix-loop-helix domains with e-box dna 2.4Å AUTH Z.WANG,Y.WU,L.LI,X.D.SUTITL INTERMOLECULAR RECOGNITION REVEALED BY THE COMPLEX STRUCTURETITL 2 OF HUMAN CLOCK-BMAL1 BASIC HELIX-LOOP-HELIX DOMAINS WITHTITL 3 E-BOX DNA.REF CELL RES. V. 23 213 2013REFN ISSN 1001-0602PMID 23229515DOI 10.1038/CR.2012.170 Variant Set Distributions […]
General Structure Information 4h10 ARNTL intermolecular recognition revealed by the complex structure of human clock-bmal1 basic helix-loop-helix domains with e-box dna 2.4Å AUTH Z.WANG,Y.WU,L.LI,X.D.SUTITL INTERMOLECULAR RECOGNITION REVEALED BY THE COMPLEX STRUCTURETITL 2 OF HUMAN CLOCK-BMAL1 BASIC HELIX-LOOP-HELIX DOMAINS WITHTITL 3 E-BOX DNA.REF CELL RES. V. 23 213 2013REFN ISSN 1001-0602PMID 23229515DOI 10.1038/CR.2012.170 Variant Set Distributions […]
General Structure Information 2f60 PDHX crystal structure of the dihydrolipoamide dehydrogenase (e3)-binding domain of human e3-binding protein 1.55Å AUTH C.A.BRAUTIGAM,R.M.WYNN,J.L.CHUANG,M.MACHIUS,D.R.TOMCHICK,AUTH 2 D.T.CHUANGTITL STRUCTURAL INSIGHT INTO INTERACTIONS BETWEENTITL 2 DIHYDROLIPOAMIDE DEHYDROGENASE (E3) AND E3 BINDING PROTEINTITL 3 OF HUMAN PYRUVATE DEHYDROGENASE COMPLEX.REF STRUCTURE V. 14 611 2006REFN ISSN 0969-2126PMID 16442803DOI 10.1016/J.STR.2006.01.001 Variant Set Distributions Mapped Variants