Assessment of Structural Intolerance and Durability
General Structure Information 2d9w DOK2 solution structure of the ph domain of docking protein 2 from human -1.0Å AUTH H.LI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF DOCKINGTITL 2 PROTEIN 2 FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2d9z PRKD3 solution structure of the ph domain of protein kinase c, nu type from human -1.0Å AUTH H.LI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF PROTEINTITL 2 KINASE C, NU TYPE FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dlx UBXN7 solution structure of the uas domain of human ubx domain- containing protein 7 -1.0Å AUTH H.P.ZHANG,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE UAS DOMAIN OF HUMAN UBXTITL 2 DOMAIN-CONTAINING PROTEIN 7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2buj STK16 crystal structure of the human serine-threonine kinase 16 in complex with staurosporine 2.6Å AUTH J.E.DEBRECZENI,J.ESWARAN,A.BULLOCK,P.FILIPPAKOPOULOS,AUTH 2 K.KAVANAGH,A.AMOS,O.FEDOROV,F.SOBOTT,L.J.BALL,F.VON DELFT,AUTH 3 C.ARROWSMITH,M.SUNDSTROM,A.EDWARDS,S.KNAPPTITL CRYSTAL STRUCTURE OF THE HUMAN SERINE-THREONINE KINASE 16TITL 2 IN COMPLEX WITH STAUROSPORINEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3puf RNASEH2A crystal structure of human rnase h2 complex 3.1Å AUTH M.FIGIEL,H.CHON,S.M.CERRITELLI,M.CYBULSKA,R.J.CROUCH,AUTH 2 M.NOWOTNYTITL THE STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF HUMANTITL 2 RNASE H2 COMPLEX REVEALS THE MOLECULAR BASIS FOR SUBSTRATETITL 3 RECOGNITION AND AICARDI-GOUTIERES SYNDROME DEFECTS.REF J.BIOL.CHEM. V. 286 10540 2011REFN ISSN 0021-9258PMID 21177858DOI 10.1074/JBC.M110.181974 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4bxu PEX14 structure of pex14 in complex with pex5 lvxef motif -1.0Å AUTH A.NEUHAUS,H.KOOSHAPUR,J.WOLF,H.N.MEYER,T.MADL,J.SAIDOWSKY,AUTH 2 E.HAMBRUCH,A.LASSAM,M.JUNG,M.SATTLER,W.SCHLIEBS,R.ERDMANNTITL A NOVEL PEX14 INTERACTING SITE OF HUMAN PEX5 IS CRITICALTITL 2 FOR MATRIX PROTEIN IMPORT INTO PEROXISOMES.REF J.BIOL.CHEM. V. 289 437 2014REFN ISSN 0021-9258PMID 24235149DOI 10.1074/JBC.M113.499707 Variant Set Distributions Mapped Variants
General Structure Information 2jsd MMP20 solution structure of mmp20 complexed with nngh -1.0Å AUTH Y.ARENDT,L.BANCI,I.BERTINI,F.CANTINI,R.COZZI,AUTH 2 R.DEL CONTE,L.GONNELLITITL CATALYTIC DOMAIN OF MMP20 (ENAMELYSIN) – THE NMRTITL 2 STRUCTURE OF A NEW MATRIX METALLOPROTEINASE.REF FEBS LETT. V. 581 4723 2007REFN ISSN 0014-5793PMID 17869250DOI 10.1016/J.FEBSLET.2007.08.069 Variant Set Distributions Mapped Variants
General Structure Information 2gwh SULT1C4 human sulfotranferase sult1c2 in complex with pap and pentachlorophenol 1.8Å AUTH A.ALLALI-HASSANI,P.W.PAN,L.DOMBROVSKI,R.NAJMANOVICH,AUTH 2 W.TEMPEL,A.DONG,P.LOPPNAU,F.MARTIN,J.THORNTON,J.THONTON,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOV,M.VEDADI,AUTH 4 C.H.ARROWSMITHTITL STRUCTURAL AND CHEMICAL PROFILING OF THE HUMAN CYTOSOLICTITL 2 SULFOTRANSFERASES.REF PLOS BIOL. V. 5 E97 2007REFN ISSN 1544-9173PMID 17425406DOI 10.1371/JOURNAL.PBIO.0050097 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2xrf UPP2 crystal structure of human uridine phosphorylase 2 2.3Å AUTH M.WELIN,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,T.KOTENYOVA,AUTH 4 E.KOUZNETSOVA,T.NYMAN,C.PERSSON,H.SCHULER,P.SCHUTZ,AUTH 5 M.I.SIPONEN,A.G.THORSELL,L.TRESAUGUES,S.VAN DER BERG,AUTH 6 E.WAHLBERG,J.WEIGELT,P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN URIDINE PHOSPHORYLASE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2iwq MPDZ 7th pdz domain of multiple pdz domain protein mpdz 1.8Å AUTH J.M.ELKINS,E.PAPAGRIGORIOU,G.BERRIDGE,X.YANG,C.PHILLIPS,AUTH 2 C.GILEADI,P.SAVITSKY,D.A.DOYLETITL STRUCTURE OF PICK1 AND OTHER PDZ DOMAINS OBTAINED WITH THETITL 2 HELP OF SELF-BINDING C-TERMINAL EXTENSIONS.REF PROTEIN SCI. V. 16 683 2007REFN ISSN 0961-8368PMID 17384233DOI 10.1110/PS.062657507 Variant Set Distributions Mapped Variants