Assessment of Structural Intolerance and Durability
General Structure Information 4dlo BAI3 crystal structure of the gain and hormr domains of brain angiogenesis inhibitor 3 (bai3) 2.3Å AUTH D.ARAC,A.A.BOUCARD,M.F.BOLLIGER,J.NGUYEN,S.M.SOLTIS,AUTH 2 T.C.SUDHOF,A.T.BRUNGERTITL A NOVEL EVOLUTIONARILY CONSERVED DOMAIN OF CELL-ADHESIONTITL 2 GPCRS MEDIATES AUTOPROTEOLYSIS.REF EMBO J. V. 31 1364 2012REFN ISSN 0261-4189PMID 22333914DOI 10.1038/EMBOJ.2012.26 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2lsp BRD4 solution structures of brd4 second bromodomain with nf-kb-k310ac peptide -1.0Å AUTH G.ZHANG,R.LIU,Y.ZHONG,A.N.PLOTNIKOV,W.ZHANG,L.ZENG,AUTH 2 E.RUSINOVA,G.GERONA-NEVARRO,N.MOSHKINA,J.JOSHUA,P.Y.CHUANG,AUTH 3 M.OHLMEYER,J.C.HE,M.M.ZHOUTITL DOWN-REGULATION OF NF-KAPPA B TRANSCRIPTIONAL ACTIVITY INTITL 2 HIV-ASSOCIATED KIDNEY DISEASE BY BRD4 INHIBITION.REF J.BIOL.CHEM. V. 287 28840 2012REFN ISSN 0021-9258PMID 22645123DOI 10.1074/JBC.M112.359505 Variant Set Distributions Mapped Variants
General Structure Information 4mbb DUSP11 cubic crystal form of pir1 dual specificity phosphatase core 1.85Å AUTH R.S.SANKHALA,R.K.LOKAREDDY,G.CINGOLANITITL STRUCTURE OF HUMAN PIR1, AN ATYPICAL DUAL-SPECIFICITYTITL 2 PHOSPHATASE.REF BIOCHEMISTRY V. 53 862 2014REFN ISSN 0006-2960PMID 24447265DOI 10.1021/BI401240X Variant Set Distributions Mapped Variants
General Structure Information 3l50 GMFG the crystal structure of human glia maturation factor, gamma (gmfg) 1.9Å AUTH E.UGOCHUKWU,E.PILKA,E.KRYSZTOFINSKA,E.HAPKA,T.KROJER,AUTH 2 J.MUNIZ,M.VOLLMAR,A.C.W.PIKE,F.VON DELFT,K.L.KAVANAGH,AUTH 3 U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN GLIA MATURATION FACTOR, GAMMATITL 2 (GMFG)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4ihb DYSF x-ray structure of the canonical c2a domain from human dysferlin 2.04Å AUTH K.FUSON,A.RICE,R.MAHLING,A.SNOW,K.NAYAK,P.SHANBHOGUE,AUTH 2 A.G.MEYER,G.M.REDPATH,A.HINDERLITER,S.T.COOPER,R.B.SUTTONTITL ALTERNATE SPLICING OF DYSFERLIN C2A CONFERS CA(2+)-DEPENDENTTITL 2 AND CA(2+)-INDEPENDENT BINDING FOR MEMBRANE REPAIR.REF STRUCTURE V. 22 104 2014REFN ISSN 0969-2126PMID 24239457DOI 10.1016/J.STR.2013.10.001 Variant Set Distributions Mapped Variants
General Structure Information 2e9j FLNB solution structure of the 14th filamin domain from human filamin-b -1.0Å AUTH T.TOMIZAWA,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 14TH FILAMIN DOMAIN FROMTITL 2 HUMAN FILAMIN-BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2fyt PRMT3 human hmt1 hnrnp methyltransferase-like 3 (s. cerevisiae) protein 2.0Å AUTH H.WU,J.R.MIN,H.ZENG,P.LOPPNAU,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN HMT1 HNRNPTITL 2 METHYLTRANSFERASE-LIKE 3 IN COMPLEX WITH SAH.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1t0l IDH1 crystal structure of human cytosolic nadp(+)-dependent isocitrate dehydrogenase in complex with nadp, isocitrate, and calcium(2+) 2.41Å AUTH X.XU,J.ZHAO,Z.XU,B.PENG,Q.HUANG,E.ARNOLD,J.DINGTITL STRUCTURES OF HUMAN CYTOSOLIC NADP-DEPENDENTTITL 2 ISOCITRATE DEHYDROGENASE REVEAL A NOVELTITL 3 SELF-REGULATORY MECHANISM OF ACTIVITYREF J.BIOL.CHEM. V. 279 33946 2004REFN ISSN 0021-9258PMID 15173171DOI 10.1074/JBC.M404298200 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1v9v MAST3 solution structure of putative domain of human kiaa0561 protein -1.0Å AUTH N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF PUTATIVE DOMAIN OF HUMANTITL 2 KIAA0561 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2vyi SGTA crystal structure of the tpr domain of human sgt 2.4Å AUTH S.DUTTA,Y.J.TANTITL STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OFTITL 2 HUMAN SGT AND ITS INTERACTION WITH VPU OF THETITL 3 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1.REF BIOCHEMISTRY V. 47 10123 2008REFN ISSN 0006-2960PMID 18759457DOI 10.1021/BI800758A Variant Set Distributions Mapped Variants