Assessment of Structural Intolerance and Durability
General Structure Information 4d8k LCK crystal structure of a sh3-sh2 domains of a lymphocyte-specific protein tyrosine kinase (lck) from homo sapiens at 2.36 a resolution 2.36Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 2 PARTNERSHIP FOR T-CELL BIOLOGYTITL CRYSTAL STRUCTURE OF A SH3-SH2 DOMAINS OF ATITL 2 LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE (LCK) FROM HOMOTITL 3 […]
General Structure Information 3it8 TNF crystal structure of tnf alpha complexed with a poxvirus mhc-related tnf binding protein 2.8Å AUTH Z.YANG,A.P.WEST JR.,P.J.BJORKMANTITL CRYSTAL STRUCTURE OF TNFA COMPLEXED WITH A POXVIRUSTITL 2 MHC-RELATED TNF BINDING PROTEINREF NAT.STRUCT.MOL.BIOL.REFN ESSN 1545-9985DOI 10.1038/NSMB.1683 Variant Set Distributions Mapped Variants
General Structure Information 3w97 HIST1H2AE crystal structure of human nucleosome core particle lacking h2b n- terminal region 3.2Å AUTH W.IWASAKI,Y.MIYA,N.HORIKOSHI,A.OSAKABE,H.TAGUCHI,AUTH 2 H.TACHIWANA,T.SHIBATA,W.KAGAWA,H.KURUMIZAKATITL CONTRIBUTION OF HISTONE N-TERMINAL TAILS TO THE STRUCTURETITL 2 AND STABILITY OF NUCLEOSOMESREF FEBS OPEN BIO V. 3 363 2013REFN ESSN 2211-5463PMID 24251097DOI 10.1016/J.FOB.2013.08.007 Variant Set Distributions Mapped Variants
General Structure Information 3n06 PRL a mutant human prolactin receptor antagonist h27a in complex with the extracellular domain of the human prolactin receptor 2.0Å AUTH M.V.KULKARNI,M.C.TETTAMANZI,J.W.MURPHY,C.KEELER,D.G.MYSZKA,AUTH 2 N.E.CHAYEN,E.J.LOLIS,M.E.HODSDONTITL TWO INDEPENDENT HISTIDINES, ONE IN HUMAN PROLACTIN AND ONETITL 2 IN ITS RECEPTOR, ARE CRITICAL FOR PH-DEPENDENT RECEPTORTITL 3 RECOGNITION AND ACTIVATION.REF J.BIOL.CHEM. V. 285 38524 2010REFN […]
General Structure Information 2xwb C3 crystal structure of complement c3b in complex with factors b and d 3.49Å AUTH F.FORNERIS,D.RICKLIN,J.WU,A.TZEKOU,R.S.WALLACE,J.D.LAMBRIS,AUTH 2 P.GROSTITL STRUCTURES OF C3B IN COMPLEX WITH FACTORS B AND D GIVETITL 2 INSIGHT INTO COMPLEMENT CONVERTASE FORMATION.REF SCIENCE V. 330 1816 2010REFN ISSN 0036-8075PMID 21205667DOI 10.1126/SCIENCE.1195821 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2xwb CFB crystal structure of complement c3b in complex with factors b and d 3.49Å AUTH F.FORNERIS,D.RICKLIN,J.WU,A.TZEKOU,R.S.WALLACE,J.D.LAMBRIS,AUTH 2 P.GROSTITL STRUCTURES OF C3B IN COMPLEX WITH FACTORS B AND D GIVETITL 2 INSIGHT INTO COMPLEMENT CONVERTASE FORMATION.REF SCIENCE V. 330 1816 2010REFN ISSN 0036-8075PMID 21205667DOI 10.1126/SCIENCE.1195821 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1ron NPY nmr solution structure of human neuropeptide y -1.0Å AUTH S.A.MONKS,G.KARAGIANIS,G.J.HOWLETT,R.S.NORTONTITL SOLUTION STRUCTURE OF HUMAN NEUROPEPTIDE Y.REF J.BIOMOL.NMR V. 8 379 1996REFN ISSN 0925-2738PMID 9008359DOI 10.1007/BF00228141 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1nr1 GLUD1 crystal structure of the r463a mutant of human glutamate dehydrogenase 3.3Å AUTH S.BANERJEE,T.SCHMIDT,J.FANG,C.A.STANLEY,T.J.SMITHTITL STRUCTURAL STUDIES ON ADP ACTIVATION OF MAMMALIANTITL 2 GLUTAMATE DEHYDROGENASE AND THE EVOLUTION OFTITL 3 REGULATIONREF BIOCHEMISTRY V. 42 3446 2003REFN ISSN 0006-2960PMID 12653548DOI 10.1021/BI0206917 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ksn F10 crystal structure of human coagulation factor xa complexed with fxv673 2.1Å AUTH K.R.GUERTIN,C.J.GARDNER,S.I.KLEIN,A.L.ZULLI,AUTH 2 M.CZEKAJ,Y.GONG,A.P.SPADA,D.L.CHENEY,S.MAIGNAN,AUTH 3 J.P.GUILLOTEAU,K.D.BROWN,D.J.COLUSSI,V.CHU,AUTH 4 C.L.HERAN,S.R.MORGAN,R.G.BENTLEY,C.T.DUNWIDDIE,AUTH 5 R.J.LEADLEY,H.W.PAULSTITL OPTIMIZATION OF THE BETA-AMINOESTER CLASS OFTITL 2 FACTOR XA INHIBITORS. PART 2: IDENTIFICATION OFTITL 3 FXV673 AS A POTENT AND SELECTIVE INHIBITOR WITHTITL 4 EXCELLENT IN VIVO ANTICOAGULANT ACTIVITY.REF […]
General Structure Information 1qub APOH crystal structure of the glycosylated five-domain human beta2- glycoprotein i purified from blood plasma 2.7Å AUTH B.BOUMA,P.G.DE GROOT,J.M.VAN DEN ELSEN,R.B.RAVELLI,AUTH 2 A.SCHOUTEN,M.J.SIMMELINK,R.H.DERKSEN,J.KROON,P.GROSTITL ADHESION MECHANISM OF HUMAN BETA(2)-GLYCOPROTEIN I TOTITL 2 PHOSPHOLIPIDS BASED ON ITS CRYSTAL STRUCTURE.REF EMBO J. V. 18 5166 1999REFN ISSN 0261-4189PMID 10508150DOI 10.1093/EMBOJ/18.19.5166 Variant Set Distributions Ripley’s […]