Assessment of Structural Intolerance and Durability
General Structure Information 1yjd CD28 crystal structure of human cd28 in complex with the fab fragment of a mitogenic antibody (5.11a1) 2.7Å AUTH E.J.EVANS,R.M.ESNOUF,R.MANSO-SANCHO,R.J.C.GILBERT,J.R.JAMES,AUTH 2 C.YU,J.A.FENNELLY,C.VOWLES,T.HANKE,B.WALSE,T.HUNIG,AUTH 3 P.SORENSEN,D.I.STUART,S.J.DAVISTITL CRYSTAL STRUCTURE OF A SOLUBLE CD28-FAB COMPLEXREF NAT.IMMUNOL. V. 6 271 2005REFN ISSN 1529-2908PMID 15696168DOI 10.1038/NI1170 Variant Set Distributions Mapped Variants
General Structure Information 1erv TXN human thioredoxin mutant with cys 73 replaced by ser (reduced form) 1.65Å AUTH A.WEICHSEL,J.R.GASDASKA,G.POWIS,W.R.MONTFORTTITL CRYSTAL STRUCTURES OF REDUCED, OXIDIZED, ANDTITL 2 MUTATED HUMAN THIOREDOXINS: EVIDENCE FOR ATITL 3 REGULATORY HOMODIMER.REF STRUCTURE V. 4 735 1996REFN ISSN 0969-2126PMID 8805557DOI 10.1016/S0969-2126(96)00079-2 Variant Set Distributions Mapped Variants
General Structure Information 2dob PSAP crystal structure of human saposin a 2.0Å AUTH V.E.AHN,P.LEYKO,J.R.ALATTIA,L.CHEN,G.G.PRIVETITL CRYSTAL STRUCTURES OF SAPOSINS A AND C.REF PROTEIN SCI. V. 15 1849 2006REFN ISSN 0961-8368PMID 16823039DOI 10.1110/PS.062256606 Variant Set Distributions Mapped Variants
General Structure Information 3lbx SPTB crystal structure of the erythrocyte spectrin tetramerization domain complex 2.8Å AUTH J.J.IPSARO,S.L.HARPER,T.E.MESSICK,R.MARMORSTEIN,A.MONDRAGON,AUTH 2 D.W.SPEICHERTITL CRYSTAL STRUCTURE AND FUNCTIONAL INTERPRETATION OF THETITL 2 ERYTHROCYTE SPECTRIN TETRAMERIZATION DOMAIN COMPLEX.REF BLOOD V. 115 4843 2010REFN ISSN 0006-4971PMID 20197550DOI 10.1182/BLOOD-2010-01-261396 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wns UMPS human orotate phosphoribosyltransferase (oprtase) domain of uridine 5-monophosphate synthase (umps) in complex with its substrate orotidine 5-monophosphate (omp) 1.9Å AUTH M.MOCHE,A.ROOS,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTYENOVA,A.KOTZCH,T.K.NIELSEN,T.NYMAN,C.PERSSON,AUTH 5 J.SAGEMARK,H.SCHUELER,P.SCHUTZ,M.I.SIPONEN,AUTH 6 L.SVENSSON,A.G.THORSELL,L.TRESAUGUES,S.VANDENBERG,AUTH 7 J.WEIGELT,M.WELIN,M.WISNIEWSKA,P.NORDLUNDTITL HUMAN OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRTASE)TITL 2 DOMAIN OF URIDINE 5-MONOPHOSPHATE SYNTHASE (UMPS)TITL 3 IN COMPLEX WITH ITS SUBSTRATE […]
General Structure Information 2c7a PGR structure of the progesterone receptor-dna complex 2.5Å AUTH S.C.ROEMER,D.C.DONHAM,L.SHERMAN,V.H.PON,AUTH 2 D.P.EDWARDS,M.E.A.CHURCHILLTITL STRUCTURE OF THE PROGESTERONE RECEPTOR-TITL 2 DEOXYRIBONUCLEIC ACID COMPLEX: NOVEL INTERACTIONSTITL 3 REQUIRED FOR BINDING TO HALF-SITE RESPONSETITL 4 ELEMENTS.REF MOL.ENDOCRINOL. V. 20 3042 2006REFN ISSN 0888-8809PMID 16931575DOI 10.1210/ME.2005-0511 Variant Set Distributions Mapped Variants
General Structure Information 1og2 CYP2C9 structure of human cytochrome p450 cyp2c9 2.6Å AUTH P.A.WILLIAMS,J.COSME,A.WARD,H.C.ANGOVE,AUTH 2 D.MATAK VINKOVIC,H.JHOTITITL CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 2C9TITL 2 WITH BOUND WARFARINREF NATURE V. 424 464 2003REFN ISSN 0028-0836PMID 12861225DOI 10.1038/NATURE01862 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4kmd GLI1 crystal structure of sufud60-gli1p 1.7Å AUTH Y.ZHANG,L.FU,X.QI,Z.ZHANG,Y.XIA,J.JIA,J.JIANG,Y.ZHAO,G.WUTITL STRUCTURAL INSIGHT INTO THE MUTUAL RECOGNITION ANDTITL 2 REGULATION BETWEEN SUPPRESSOR OF FUSED AND GLI/CI.REF NAT COMMUN V. 4 2608 2013REFN ESSN 2041-1723PMID 24217340DOI 10.1038/NCOMMS3608 Variant Set Distributions Mapped Variants
General Structure Information 2dh3 SLC3A2 crystal structure of human ed-4f2hc 2.8Å AUTH J.FORT,L.R.DE LA BALLINA,H.E.BURGHARDT,C.FERRER-COSTA,AUTH 2 J.TURNAY,C.FERRER-ORTA,I.USON,A.ZORZANO,J.FERNANDEZ-RECIO,AUTH 3 M.OROZCO,M.A.LIZARBE,I.FITA,M.PALACINTITL THE STRUCTURE OF HUMAN 4F2HC ECTODOMAIN PROVIDES A MODEL FORTITL 2 HOMODIMERIZATION AND ELECTROSTATIC INTERACTION WITH PLASMATITL 3 MEMBRANE.REF J.BIOL.CHEM. V. 282 31444 2007REFN ISSN 0021-9258PMID 17724034DOI 10.1074/JBC.M704524200 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3qum KLK3 crystal structure of human prostate specific antigen (psa) in fab sandwich with a high affinity and a pca selective antibody 3.2Å AUTH E.A.STURA,B.H.MULLER,M.BOSSUS,S.MICHEL,C.JOLIVET-REYNAUD,AUTH 2 F.DUCANCELTITL CRYSTAL STRUCTURE OF HUMAN PROSTATE-SPECIFIC ANTIGEN IN ATITL 2 SANDWICH ANTIBODY COMPLEX.REF J.MOL.BIOL. V. 414 530 2011REFN ISSN 0022-2836PMID 22037582DOI 10.1016/J.JMB.2011.10.007 Variant Set Distributions Ripley’s […]