Assessment of Structural Intolerance and Durability
General Structure Information 1yk0 NPR3 structure of natriuretic peptide receptor-c complexed with atrial natriuretic peptide 2.4Å AUTH X.L.HE,A.DUKKIPATI,K.C.GARCIATITL STRUCTURAL DETERMINANTS OF NATRIURETIC PEPTIDE RECEPTORTITL 2 SPECIFICITY AND DEGENERACY.REF J.MOL.BIOL. V. 361 698 2006REFN ISSN 0022-2836PMID 16870210DOI 10.1016/J.JMB.2006.06.060 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1cdq CD59 structure of a soluble, glycosylated form of the human complement regulatory protein cd59 -1.0Å AUTH C.M.FLETCHER,R.A.HARRISON,P.J.LACHMANN,D.NEUHAUSTITL STRUCTURE OF A SOLUBLE, GLYCOSYLATED FORM OF THETITL 2 HUMAN COMPLEMENT REGULATORY PROTEIN CD59.REF STRUCTURE V. 2 185 1994REFN ISSN 0969-2126PMID 7520819DOI 10.1016/S0969-2126(00)00020-4 Variant Set Distributions Mapped Variants
General Structure Information 1ext TNFRSF1A extracellular domain of the 55kda tumor necrosis factor receptor. crystallized at ph3.7 in p 21 21 21. 1.85Å AUTH J.H.NAISMITH,T.Q.DEVINE,T.KOHNO,S.R.SPRANGTITL STRUCTURES OF THE EXTRACELLULAR DOMAIN OF THE TYPETITL 2 I TUMOR NECROSIS FACTOR RECEPTOR.REF STRUCTURE V. 4 1251 1996REFN ISSN 0969-2126PMID 8939750DOI 10.1016/S0969-2126(96)00134-7 Variant Set Distributions Pathogenic Proximity Analysis Mapped […]
General Structure Information 1op8 GZMA crystal structure of human granzyme a 2.5Å AUTH C.HINK-SCHAUER,E.ESTEBANEZ-PERPINA,F.KURSCHUS,AUTH 2 W.BODE,D.JENNETITL CRYSTAL STRUCTURE OF THE APOPTOSIS-INDUCING HUMANTITL 2 GRANZYME A DIMERREF NAT.STRUCT.BIOL. V. 10 535 2003REFN ISSN 1072-8368PMID 12819770DOI 10.1038/NSB945 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1lx5 BMP7 crystal structure of the bmp7/actrii extracellular domain complex 3.3Å AUTH J.GREENWALD,J.GROPPE,P.GRAY,E.WIATER,W.KWIATKOWSKI,W.VALE,AUTH 2 S.CHOETITL THE BMP7/ACTRII EXTRACELLULAR DOMAIN COMPLEX PROVIDES NEWTITL 2 INSIGHTS INTO THE COOPERATIVE NATURE OF RECEPTOR ASSEMBLYREF MOL.CELL V. 11 605 2003REFN ISSN 1097-2765PMID 12667445DOI 10.1016/S1097-2765(03)00094-7 Variant Set Distributions Mapped Variants
General Structure Information 4kki TCN1 crystal structure of haptocorrin in complex with cncbl 2.35Å AUTH E.FURGER,D.C.FREI,R.SCHIBLI,E.FISCHER,A.E.PROTATITL STRUCTURAL BASIS FOR UNIVERSAL CORRINOID RECOGNITION BY THETITL 2 COBALAMIN TRANSPORT PROTEIN HAPTOCORRIN.REF J.BIOL.CHEM. V. 288 25466 2013REFN ISSN 0021-9258PMID 23846701DOI 10.1074/JBC.M113.483271 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3km0 HSD17B1 17betahsd1 in complex with 3beta-diol 2.3Å AUTH M.MAZUMDAR,J.CHEN,S.-X.LINTITL MOLECULAR BASIS OF SEX-STEROID TRANSLATIONREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1pv8 ALAD crystal structure of a low activity f12l mutant of human porphobilinogen synthase 2.2Å AUTH S.BREINIG,J.KERVINEN,L.STITH,A.S.WASSON,R.FAIRMAN,AUTH 2 A.WLODAWER,A.ZDANOV,E.K.JAFFETITL CONTROL OF TETRAPYRROLE BIOSYNTHESIS BY ALTERNATE QUATERNARYTITL 2 FORMS OF PORPHOBILINOGEN SYNTHASE.REF NAT.STRUCT.BIOL. V. 10 757 2003REFN ISSN 1072-8368PMID 12897770DOI 10.1038/NSB963 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1uch UCHL3 deubiquitinating enzyme uch-l3 (human) at 1.8 angstrom resolution 1.8Å AUTH S.C.JOHNSTON,C.N.LARSEN,W.J.COOK,K.D.WILKINSON,AUTH 2 C.P.HILLTITL CRYSTAL STRUCTURE OF A DEUBIQUITINATING ENZYMETITL 2 (HUMAN UCH-L3) AT 1.8 A RESOLUTION.REF EMBO J. V. 16 3787 1997REFN ISSN 0261-4189PMID 9233788DOI 10.1093/EMBOJ/16.13.3787 Variant Set Distributions Mapped Variants
General Structure Information 2eyi ACTN1 crystal structure of the actin-binding domain of human alpha-actinin 1 at 1.7 angstrom resolution 1.7Å AUTH E.BORREGO-DIAZ,F.KERFF,S.H.LEE,F.FERRON,Y.LI,AUTH 2 R.DOMINGUEZTITL CRYSTAL STRUCTURE OF THE ACTIN-BINDING DOMAIN OFTITL 2 ALPHA-ACTININ 1: EVALUATING TWO COMPETINGTITL 3 ACTIN-BINDING MODELS.REF J.STRUCT.BIOL. V. 155 230 2006REFN ISSN 1047-8477PMID 16698282DOI 10.1016/J.JSB.2006.01.013 Variant Set Distributions Pathogenic Proximity Analysis […]