Assessment of Structural Intolerance and Durability
General Structure Information 3owh NQO2 x-ray structural study of quinone reductase ii inhibition by compounds with micromolar to nanomolar range ic50 values 2.28Å AUTH S.D.PEGAN,M.STURDY,G.FERRY,P.DELAGRANGE,J.A.BOUTIN,AUTH 2 A.D.MESECARTITL X-RAY STRUCTURAL STUDIES OF QUINONE REDUCTASE 2 NANOMOLARTITL 2 RANGE INHIBITORS.REF PROTEIN SCI. V. 20 1182 2011REFN ISSN 0961-8368PMID 21538647DOI 10.1002/PRO.647 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2z6k RPA2 crystal structure of full-length human rpa14/32 heterodimer 3.0Å AUTH X.DENG,J.E.HABEL,V.KABALEESWARAN,E.H.SNELL,AUTH 2 M.S.WOLD,G.E.BORGSTAHLTITL STRUCTURE OF THE FULL-LENGTH HUMAN RPA14/32TITL 2 COMPLEX GIVES INSIGHTS INTO THE MECHANISM OF DNATITL 3 BINDING AND COMPLEX FORMATIONREF J.MOL.BIOL. V. 374 865 2007REFN ISSN 0022-2836PMID 17976647DOI 10.1016/J.JMB.2007.09.074 Variant Set Distributions Mapped Variants
General Structure Information 1qnk CXCL2 truncated human grob[5-73], nmr, 20 structures -1.0Å AUTH Y.Q.QIAN,K.JOHANSON,P.MCDEVITTTITL NUCLEAR MAGNETIC RESONANCE SOLUTION STRUCTURE OFTITL 2 TRUNCATED HUMAN GROBETA [5-73] AND ITS STRUCTURALTITL 3 COMPARISON WITH CXC CHEMOKINE FAMILY MEMBERSTITL 4 GROALPHA AND IL-8.REF J.MOL.BIOL. V. 294 1065 1999REFN ISSN 0022-2836PMID 10600366DOI 10.1006/JMBI.1999.3333 Variant Set Distributions Mapped Variants
General Structure Information 2fc8 NCL solution structure of the rrm_1 domain of ncl protein -1.0Å AUTH W.DANG,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TERADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RRM_1 DOMAIN OF NCLTITL 2 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3igu NAGA crystal structure of human alpha-n-acetylgalactosaminidase, covalent intermediate 2.15Å AUTH N.E.CLARK,S.C.GARMANTITL THE 1.9 A STRUCTURE OF HUMANTITL 2 ALPHA-N-ACETYLGALACTOSAMINIDASE: THE MOLECULAR BASIS OFTITL 3 SCHINDLER AND KANZAKI DISEASESREF J.MOL.BIOL. V. 393 435 2009REFN ISSN 0022-2836PMID 19683538DOI 10.1016/J.JMB.2009.08.021 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1kq6 NCF1 p47phox px domain 1.18Å AUTH M.WAHL,H.DELBRUECK,H.OSCHKINAT,U.HEINEMANNTITL P47PHOX PX DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1g1q SELP crystal structure of p-selectin lectin/egf domains 2.4Å AUTH W.S.SOMERS,J.TANG,G.D.SHAW,R.T.CAMPHAUSENTITL INSIGHTS INTO THE MOLECULAR BASIS OF LEUKOCYTETITL 2 TETHERING AND ROLLING REVEALED BY STRUCTURES OF P-TITL 3 AND E-SELECTIN BOUND TO SLE(X) AND PSGL-1.REF CELL(CAMBRIDGE,MASS.) V. 103 467 2000REFN ISSN 0092-8674PMID 11081633DOI 10.1016/S0092-8674(00)00138-0 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3sp8 HGF crystal structure of nk2 in complex with fractionated heparin dp10 1.86Å AUTH R.RECACHA,B.MULLOY,E.GHERARDITITL CRYSTAL STRUCTURE OF NK2 IN COMPLEX WITH FRACTIONATEDTITL 2 HEPARIN DP10REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1j1a PLA2G2A pancreatic secretory phospholipase a2 (iia) with anti- inflammatory activity 2.2Å AUTH K.A.HANSFORD,R.C.REID,C.I.CLARK,J.D.A.TYNDALL,AUTH 2 M.W.WHITEHOUSE,T.GUTHRIE,R.P.MCGEARY,K.SCHAFER,AUTH 3 J.L.MARTIN,D.P.FAIRLIETITL D-TYROSINE AS A CHIRAL PRECUSOR TO POTENTTITL 2 INHIBITORS OF HUMAN NONPANCREATIC SECRETORYTITL 3 PHOSPHOLIPASE A2 (IIA) WITH ANTIINFLAMMATORYTITL 4 ACTIVITYREF CHEMBIOCHEM V. 4 181 2003REFN ISSN 1439-4227PMID 12616631DOI 10.1002/CBIC.200390029 Variant Set Distributions Mapped […]
General Structure Information 4dnl PRKCA crystal structure of a c2 domain of a protein kinase c alpha (prkca) from homo sapiens at 1.90 a resolution 1.9Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 2 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL CRYSTAL STRUCTURE OF A C2 DOMAIN OF A PROTEIN KINASE C ALPHATITL 2 (PRKCA) FROM HOMO […]