Assessment of Structural Intolerance and Durability
General Structure Information 1cdz XRCC1 brct domain from dna-repair protein xrcc1 3.2Å AUTH X.ZHANG,S.MORERA,P.A.BATES,P.C.WHITEHEAD,AUTH 2 A.I.COFFER,K.HAINBUCHER,R.A.NASH,M.J.STERNBERG,AUTH 3 T.LINDAHL,P.S.FREEMONTTITL STRUCTURE OF AN XRCC1 BRCT DOMAIN: A NEWTITL 2 PROTEIN-PROTEIN INTERACTION MODULE.REF EMBO J. V. 17 6404 1998REFN ISSN 0261-4189PMID 9799248DOI 10.1093/EMBOJ/17.21.6404 Variant Set Distributions Mapped Variants
General Structure Information 1lm7 DSP structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure 3.0Å AUTH H.J.CHOI,S.PARK-SNYDER,L.T.PASCOE,K.J.GREEN,AUTH 2 W.I.WEISTITL STRUCTURES OF TWO INTERMEDIATE FILAMENT-BINDINGTITL 2 FRAGMENTS OF DESMOPLAKIN REVEAL A UNIQUE REPEATTITL 3 MOTIF STRUCTURE.REF NAT.STRUCT.BIOL. V. 9 612 2002REFN ISSN 1072-8368PMID 12101406 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1efv ETFA three-dimensional structure of human electron transfer flavoprotein to 2.1 a resolution 2.1Å AUTH D.L.ROBERTS,F.E.FRERMAN,J.J.KIMTITL THREE-DIMENSIONAL STRUCTURE OF HUMAN ELECTRONTITL 2 TRANSFER FLAVOPROTEIN TO 2.1-A RESOLUTION.REF PROC.NATL.ACAD.SCI.USA V. 93 14355 1996REFN ISSN 0027-8424PMID 8962055DOI 10.1073/PNAS.93.25.14355 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2okn PEPD crystal strcture of human prolidase 2.45Å AUTH U.MUELLER,F.H.NIESEN,Y.ROSKE,F.GOETZ,J.BEHLKE,K.BUESSOW,AUTH 2 U.HEINEMANNTITL CRYSTAL STRUCTURE OF HUMAN PROLIDASE: THE MOLECULAR BASIS OFTITL 2 PD DISEASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1a12 RCC1 regulator of chromosome condensation (rcc1) of human 1.7Å AUTH L.RENAULT,N.NASSAR,I.VETTER,J.BECKER,C.KLEBE,AUTH 2 M.ROTH,A.WITTINGHOFERTITL THE 1.7 A CRYSTAL STRUCTURE OF THE REGULATOR OFTITL 2 CHROMOSOME CONDENSATION (RCC1) REVEALS ATITL 3 SEVEN-BLADED PROPELLER.REF NATURE V. 392 97 1998REFN ISSN 0028-0836PMID 9510255DOI 10.1038/32204 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1wun F3 human factor viia-tissue factor complexed with ethylsulfonamide-d-trp-gln-p-aminobenzamidine 2.4Å AUTH S.KADONO,A.SAKAMOTO,Y.KIKUCHI,M.OH-EDA,N.YABUTA,AUTH 2 K.YOSHIHASHI,T.KITAZAWA,T.SUZUKI,T.KOGA,K.HATTORI,AUTH 3 T.SHIRAISHI,M.HARAMURA,H.KODAMA,Y.ONO,T.ESAKI,AUTH 4 H.SATO,Y.WATANABE,S.ITOH,M.OHTA,T.KOZONOTITL STRUCTURE-BASED DESIGN OF P3 MOIETIES IN THETITL 2 PEPTIDE MIMETIC FACTOR VIIA INHIBITORREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 327 589 2005REFN ISSN 0006-291XPMID 15629154DOI 10.1016/J.BBRC.2004.12.042 Variant Set Distributions Mapped Variants
General Structure Information 1tr2 VCL crystal structure of human full-length vinculin (residues 1- 1066) 2.9Å AUTH R.A.BORGON,C.VONRHEIN,G.BRICOGNE,P.R.BOIS,T.IZARDTITL CRYSTAL STRUCTURE OF HUMAN VINCULINREF STRUCTURE V. 12 1189 2004REFN ISSN 0969-2126PMID 15242595DOI 10.1016/J.STR.2004.05.00 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3dre CKB crystal structure of human brain-type creatine kinase 2.2Å AUTH S.M.BONG,J.H.MOON,K.H.NAM,K.S.LEE,Y.M.CHI,K.Y.HWANGTITL STRUCTURAL STUDIES OF HUMAN BRAIN-TYPE CREATINETITL 2 KINASE COMPLEXED WITH THE ADP-MG2+-NO3- -CREATINETITL 3 TRANSITION-STATE ANALOGUE COMPLEXREF FEBS LETT. V. 582 3959 2008REFN ISSN 0014-5793PMID 18977227DOI 10.1016/J.FEBSLET.2008.10.039 Variant Set Distributions Mapped Variants
General Structure Information 1kfx CAPN2 crystal structure of human m-calpain form i 3.15Å AUTH S.STROBL,C.FERNANDEZ-CATALAN,M.BRAUN,R.HUBER,H.MASUMOTO,AUTH 2 K.NAKAGAWA,A.IRIE,H.SORIMACHI,G.BOURENKOW,H.BARTUNIK,AUTH 3 K.SUZUKI,W.BODETITL THE CRYSTAL STRUCTURE OF CALCIUM-FREE HUMAN M-CALPAINTITL 2 SUGGESTS AN ELECTROSTATIC SWITCH MECHANISM FOR ACTIVATION BYTITL 3 CALCIUM.REF PROC.NATL.ACAD.SCI.USA V. 97 588 2000REFN ISSN 0027-8424PMID 10639123DOI 10.1073/PNAS.97.2.588 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2bq8 ACP5 crystal structure of human purple acid phosphatase with an inhibitory conformation of the repression loop 2.2Å AUTH N.STRATER,B.JASPER,M.SCHOLTE,B.KREBS,A.P.DUFF,AUTH 2 D.B.LANGLEY,R.HAN,B.A.AVERILL,H.C.FREEMAN,J.M.GUSSTITL CRYSTAL STRUCTURES OF RECOMBINANT HUMAN PURPLETITL 2 ACID PHOSPHATASE WITH AND WITHOUT AN INHIBITORYTITL 3 CONFORMATION OF THE REPRESSION LOOP.REF J.MOL.BIOL. V. 351 233 2005REFN ISSN 0022-2836PMID 15993892DOI 10.1016/J.JMB.2005.04.014 Variant […]