Assessment of Structural Intolerance and Durability
General Structure Information 2b9r CCNB1 crystal structure of human cyclin b1 2.9Å AUTH E.T.PETRI,A.ERRICO,L.ESCOBEDO,T.HUNT,R.BASAVAPPATITL THE CRYSTAL STRUCTURE OF HUMAN CYCLIN B.REF CELL CYCLE V. 6 1342 2007REFN ISSN 1538-4101PMID 17495533 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1aoa PLS3 n-terminal actin-crosslinking domain from human fimbrin 2.4Å AUTH S.C.GOLDSMITH,N.POKALA,W.SHEN,A.A.FEDOROV,AUTH 2 P.MATSUDAIRA,S.C.ALMOTITL THE STRUCTURE OF AN ACTIN-CROSSLINKING DOMAIN FROMTITL 2 HUMAN FIMBRIN.REF NAT.STRUCT.BIOL. V. 4 708 1997REFN ISSN 1072-8368PMID 9302997DOI 10.1038/NSB0997-708 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2hnx FABP4 crystal structure of ap2 1.5Å AUTH E.MARR,M.TARDIE,M.CARTY,T.BROWN PHILLIPS,I.K.WANG,AUTH 2 W.SOELLER,X.QIU,G.KARAMTITL EXPRESSION, PURIFICATION, CRYSTALLIZATION ANDTITL 2 STRUCTURE OF HUMAN ADIPOCYTE LIPID-BINDING PROTEINTITL 3 (AP2).REF ACTA CRYSTALLOGR.,SECT.F V. 62 1058 2006REFN ESSN 1744-3091PMID 17077479DOI 10.1107/S1744309106038656 Variant Set Distributions Mapped Variants
General Structure Information 3di2 IL7R crystal structure of the complex of human interleukin-7 with unglycosylated human interleukin-7 receptor alpha ectodomain 2.7Å AUTH C.A.MCELROY,J.A.DOHM,S.T.WALSHTITL STRUCTURAL AND BIOPHYSICAL STUDIES OF THE HUMANTITL 2 IL-7/IL-7RALPHA COMPLEX.REF STRUCTURE V. 17 54 2009REFN ISSN 0969-2126PMID 19141282DOI 10.1016/J.STR.2008.10.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3di2 IL7 crystal structure of the complex of human interleukin-7 with unglycosylated human interleukin-7 receptor alpha ectodomain 2.7Å AUTH C.A.MCELROY,J.A.DOHM,S.T.WALSHTITL STRUCTURAL AND BIOPHYSICAL STUDIES OF THE HUMANTITL 2 IL-7/IL-7RALPHA COMPLEX.REF STRUCTURE V. 17 54 2009REFN ISSN 0969-2126PMID 19141282DOI 10.1016/J.STR.2008.10.019 Variant Set Distributions Mapped Variants
General Structure Information 3fe2 DDX5 human dead-box rna helicase ddx5 (p68), conserved domain i in complex with adp 2.6Å AUTH P.SCHUTZ,T.KARLBERG,S.VAN DEN BERG,R.COLLINS,L.LEHTIO,AUTH 2 M.HOGBOM,L.HOLMBERG-SCHIAVONE,W.TEMPEL,H.W.PARK,AUTH 3 M.HAMMARSTROM,M.MOCHE,A.G.THORSELL,H.SCHULERTITL COMPARATIVE STRUCTURAL ANALYSIS OF HUMAN DEAD-BOX RNATITL 2 HELICASESREF PLOS ONE V. 5 E1279 2010REFN ESSN 1932-6203PMID 20941364DOI 10.1371/JOURNAL.PONE.0012791 Variant Set Distributions Mapped Variants
General Structure Information 1nd5 ACPP crystal structures of human prostatic acid phosphatase in complex with a phosphate ion and alpha-benzylaminobenzylphosphonic acid update the mechanistic picture and offer new insights into inhibitor design 2.9Å AUTH E.ORTLUND,M.W.LACOUNT,L.LEBIODATITL CRYSTAL STRUCTURES OF HUMAN PROSTATIC ACID PHOSPHATASE INTITL 2 COMPLEX WITH A PHOSPHATE ION ANDTITL 3 ALPHA-BENZYLAMINOBENZYLPHOSPHONIC ACID UPDATE THETITL […]
General Structure Information 4fpa HK1 crystal structure of recombinant human hexokinase type i mutant d413n glucose 6-phosphate 2.48Å AUTH L.SHEN,Y.GAO,R.B.HONZATKOTITL DETERMINATION OF SITE AFFINITY CONSTANTS FOR PRODUCTTITL 2 INHIBITION OF WILD-TYPE AND MUTANT FORMS OF RECOMBINANTTITL 3 HUMAN HEXOKINASE TYPE IREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3cxl CHN1 crystal structure of human chimerin 1 (chn1) 2.6Å AUTH L.SHEN,M.BUCK,Y.TONG,W.TEMPEL,F.MACKENZIE,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,M.WILKSTROM,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN CHIMERIN 1 (CHN1).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ri4 ETS1 ets1 cooperative binding to widely separated sites on promoter dna 3.0Å AUTH N.D.BABAYEVA,O.I.BARANOVSKAYA,T.H.TAHIROVTITL STRUCTURAL BASIS OF ETS1 COOPERATIVE BINDING TO WIDELYTITL 2 SEPARATED SITES ON PROMOTER DNA.REF PLOS ONE V. 7 33698 2012REFN ESSN 1932-6203PMID 22432043DOI 10.1371/JOURNAL.PONE.0033698 Variant Set Distributions Mapped Variants