Assessment of Structural Intolerance and Durability
General Structure Information 1ef1 MSN crystal structure of the moesin ferm domain/tail domain complex 1.9Å AUTH M.A.PEARSON,D.RECZEK,A.BRETSCHER,P.A.KARPLUSTITL STRUCTURE OF THE ERM PROTEIN MOESIN REVEALS THE FERM DOMAINTITL 2 FOLD MASKED BY AN EXTENDED ACTIN BINDING TAIL DOMAIN.REF CELL(CAMBRIDGE,MASS.) V. 101 259 2000REFN ISSN 0092-8674PMID 10847681DOI 10.1016/S0092-8674(00)80836-3 Variant Set Distributions Mapped Variants
General Structure Information 2rnq GTF2E1 solution structure of the c-terminal acidic domain of tfiie alpha -1.0Å AUTH M.OKUDA,A.TANAKA,M.SATOH,S.MIZUTA,M.TAKAZAWA,AUTH 2 Y.OHKUMA,Y.NISHIMURATITL STRUCTURAL INSIGHT INTO THE TFIIE-TFIIHTITL 2 INTERACTION: TFIIE AND P53 SHARE THE BINDINGTITL 3 REGION ON TFIIHREF EMBO J. V. 27 1161 2008REFN ISSN 0261-4189PMID 18354501DOI 10.1038/EMBOJ.2008.47 Variant Set Distributions Mapped Variants
General Structure Information 1l1o RPA1 structure of the human replication protein a (rpa) trimerization core 2.8Å AUTH E.BOCHKAREVA,S.KOROLEV,S.P.LEES-MILLER,A.BOCHKAREVTITL STRUCTURE OF THE RPA TRIMERIZATION CORE AND ITSTITL 2 ROLE IN THE MULTISTEP DNA-BINDING MECHANISM OF RPA.REF EMBO J. V. 21 1855 2002REFN ISSN 0261-4189PMID 11927569DOI 10.1093/EMBOJ/21.7.1855 Variant Set Distributions Mapped Variants
General Structure Information 3i8v PDE4A crystal structure of human pde4a with 4-(3-butoxy-4-methoxyphenyl) methyl-2-imidazolidone 2.25Å AUTH R.K.Y.CHENG,L.CRAWLEY,J.BARKER,M.WOOD,B.FELICETTI,AUTH 2 M.WHITTAKERTITL CRYSTAL STRUCTURE OF HUMAN PDE4A WITHTITL 2 4-(3-BUTOXY-4-METHOXYPHENYL)METHYL-2-IMIDAZOLIDONEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2hyn PLN complete ensemble of nmr structures of unphosphorylated human phospholamban pentamer -1.0Å AUTH S.POTLURI,A.K.YAN,J.J.CHOU,B.R.DONALD,AUTH 2 C.BAILEY-KELLOGGTITL STRUCTURE DETERMINATION OF SYMMETRICTITL 2 HOMO-OLIGOMERS BY A COMPLETE SEARCH OF SYMMETRYTITL 3 CONFIGURATION SPACE, USING NMR RESTRAINTS AND VANTITL 4 DER WAALS PACKING.REF PROTEINS V. 65 203 2006REFN ISSN 0887-3585PMID 16897780DOI 10.1002/PROT.21091 Variant Set […]
General Structure Information 1a7a AHCY structure of human placental s-adenosylhomocysteine hydrolase: determination of a 30 selenium atom substructure from data at a single wavelength 2.8Å AUTH M.A.TURNER,C.S.YUAN,R.T.BORCHARDT,M.S.HERSHFIELD,G.D.SMITH,AUTH 2 P.L.HOWELLTITL STRUCTURE DETERMINATION OF SELENOMETHIONYLTITL 2 S-ADENOSYLHOMOCYSTEINE HYDROLASE USING DATA AT A SINGLETITL 3 WAVELENGTH.REF NAT.STRUCT.BIOL. V. 5 369 1998REFN ISSN 1072-8368PMID 9586999DOI 10.1038/NSB0598-369 Variant Set Distributions […]
General Structure Information 2fy5 CHAT structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis 2.6Å AUTH A.R.KIM,R.J.RYLETT,B.H.SHILTONTITL SUBSTRATE BINDING AND CATALYTIC MECHANISM OF HUMANTITL 2 CHOLINE ACETYLTRANSFERASE.REF BIOCHEMISTRY V. 45 14621 2006REFN ISSN 0006-2960PMID 17144655DOI 10.1021/BI061536L Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2qw4 NR4A1 human nr4a1 ligand-binding domain 2.8Å AUTH J.R.MIN,A.SCHUETZ,P.LOPPNAU,J.WEIGELT,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOVTITL CRYSTAL STRUCTURE OF HUMAN NR4A1 LIGAND-BINDING DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2×10 EPHA2 crystal structure of the complete epha2 ectodomain 3.0Å AUTH E.SEIRADAKE,K.HARLOS,G.SUTTON,A.R.ARICESCU,AUTH 2 E.Y.JONESTITL AN EXTRACELLULAR STERIC SEEDING MECHANISM FOR EPH-TITL 2 EPHRIN SIGNALLING PLATFORM ASSEMBLYREF NAT.STRUCT.MOL.BIOL. V. 17 398 2010REFN ISSN 1545-9993PMID 20228801DOI 10.1038/NSMB.1782 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2fi2 MZF1 solution structure of the scan homodimer from mzf-1/znf42 -1.0Å AUTH F.C.PETERSON,P.L.HAYES,J.K.WALTNER,A.K.HEISNER,AUTH 2 D.R.JENSEN,T.L.SANDER,B.F.VOLKMANTITL STRUCTURE OF THE SCAN DOMAIN FROM THE TUMORTITL 2 SUPPRESSOR PROTEIN MZF1.REF J.MOL.BIOL. V. 363 137 2006REFN ISSN 0022-2836PMID 16950398DOI 10.1016/J.JMB.2006.07.063 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants