Assessment of Structural Intolerance and Durability
General Structure Information 1rpm PTPRM human receptor protein tyrosine phosphatase mu, domain 1 2.3Å AUTH K.M.HOFFMANN,N.K.TONKS,D.BARFORDTITL THE CRYSTAL STRUCTURE OF DOMAIN 1 OF RECEPTORTITL 2 PROTEIN-TYROSINE PHOSPHATASE MU.REF J.BIOL.CHEM. V. 272 27505 1997REFN ISSN 0021-9258PMID 9346878DOI 10.1074/JBC.272.44.27505 Variant Set Distributions Mapped Variants
General Structure Information 3k72 ITGAX structure of integrin alphax beta2 3.7Å AUTH C.XIE,J.ZHU,X.CHEN,L.MI,N.NISHIDA,T.A.SPRINGERTITL STRUCTURE OF AN INTEGRIN WITH AN ALPHAI DOMAIN,TITL 2 COMPLEMENT RECEPTOR TYPE 4.REF EMBO J. V. 29 666 2010REFN ISSN 0261-4189PMID 20033057DOI 10.1038/EMBOJ.2009.367 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1cnt CNTF ciliary neurotrophic factor 2.4Å AUTH N.Q.MCDONALD,N.PANAYOTATOS,W.A.HENDRICKSONTITL CRYSTAL STRUCTURE OF DIMERIC HUMAN CILIARYTITL 2 NEUROTROPHIC FACTOR DETERMINED BY MAD PHASING.REF EMBO J. V. 14 2689 1995REFN ISSN 0261-4189PMID 7796798 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ib9 ACAT1 crystallographic and kinetic studies of human mitochondrial acetoacetyl-coa thiolase (t2): the importance of potassium and chloride for its structure and function 2.05Å AUTH A.M.HAAPALAINEN,G.MERILAINEN,P.L.PIRILA,N.KONDO,T.FUKAO,AUTH 2 R.K.WIERENGATITL CRYSTALLOGRAPHIC AND KINETIC STUDIES OF HUMAN MITOCHONDRIALTITL 2 ACETOACETYL-COA THIOLASE: THE IMPORTANCE OF POTASSIUM ANDTITL 3 CHLORIDE IONS FOR ITS STRUCTURE AND FUNCTIONREF BIOCHEMISTRY […]
General Structure Information 2vph PTPN4 crystal structure of the human protein tyrosine phosphatase, non-receptor type 4, pdz domain 1.9Å AUTH A.K.ROOS,J.WANG,N.BURGESS-BROWN,J.M.ELKINS,K.KAVANAGH,AUTH 2 A.C.W.PIKE,P.FILIPPAKOPOULOS,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 A.EDWARDS,F.VON DELFT,C.BOUNTRA,S.KNAPPTITL CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINETITL 2 PHOSPHATASE, NON-RECEPTOR TYPE 4, PDZ DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1nt3 NTF3 human neurotrophin-3 2.4Å AUTH M.J.BUTTE,P.K.HWANG,W.C.MOBLEY,R.J.FLETTERICKTITL CRYSTAL STRUCTURE OF NEUROTROPHIN-3 HOMODIMER SHOWS DISTINCTTITL 2 REGIONS ARE USED TO BIND ITS RECEPTORS.REF BIOCHEMISTRY V. 37 16846 1998REFN ISSN 0006-2960PMID 9836577DOI 10.1021/BI981254O Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kex ERBB3 crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (her3) 2.8Å AUTH N.JURA,Y.SHAN,X.CAO,D.E.SHAW,J.KURIYANTITL STRUCTURAL ANALYSIS OF THE CATALYTICALLY INACTIVETITL 2 KINASE DOMAIN OF THE HUMAN EGF RECEPTOR 3.REF PROC.NATL.ACAD.SCI.USA V. 106 21608 2009REFN ISSN 0027-8424PMID 20007378DOI 10.1073/PNAS.0912101106 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1he3 BLVRB human biliverdin ix beta reductase: nadp/mesobiliverdin iv alpha ternary complex 1.4Å AUTH P.J.B.PEREIRA,S.MACEDO-RIBEIRO,A.PARRAGA,AUTH 2 R.PEREZ-LUQUE,O.CUNNINGHAM,K.DARCY,T.J.MANTLE,AUTH 3 M.COLLTITL STRUCTURE OF HUMAN BILIVERDIN IX BETA REDUCTASE,TITL 2 AN EARLY FETAL BILIRUBIN IX PRODUCING ENZYMEREF NAT.STRUCT.BIOL. V. 8 215 2001REFN ISSN 1072-8368PMID 11224564DOI 10.1038/84948 Variant Set Distributions Mapped Variants
General Structure Information 1iil FGFR2 crystal structure of pro253arg apert mutant fgf receptor 2 (fgfr2) in complex with fgf2 2.3Å AUTH O.A.IBRAHIMI,A.V.ELISEENKOVA,A.N.PLOTNIKOV,K.YU,AUTH 2 D.M.ORNITZ,M.MOHAMMADITITL STRUCTURAL BASIS FOR FIBROBLAST GROWTH FACTORTITL 2 RECEPTOR 2 ACTIVATION IN APERT SYNDROME.REF PROC.NATL.ACAD.SCI.USA V. 98 7182 2001REFN ISSN 0027-8424PMID 11390973DOI 10.1073/PNAS.121183798 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3aad TAF1 structure of the histone chaperone cia/asf1-double bromodomain complex linking histone modifications and site-specific histone eviction 3.3Å AUTH Y.AKAI,N.ADACHI,Y.HAYASHI,M.EITOKU,N.SANO,R.NATSUME,N.KUDO,AUTH 2 M.TANOKURA,T.SENDA,M.HORIKOSHITITL STRUCTURE OF THE HISTONE CHAPERONE CIA/ASF1-DOUBLETITL 2 BROMODOMAIN COMPLEX LINKING HISTONE MODIFICATIONS ANDTITL 3 SITE-SPECIFIC HISTONE EVICTIONREF PROC.NATL.ACAD.SCI.USA V. 107 8153 2010REFN ISSN 0027-8424PMID 20393127DOI 10.1073/PNAS.0912509107 Variant Set Distributions Ripley’s […]