Assessment of Structural Intolerance and Durability
General Structure Information 1fli FLI1 dna-binding domain of fli-1 -1.0Å AUTH H.LIANG,X.MAO,E.T.OLEJNICZAK,D.G.NETTESHEIM,L.YU,AUTH 2 R.P.MEADOWS,C.B.THOMPSON,S.W.FESIKTITL SOLUTION STRUCTURE OF THE ETS DOMAIN OF FLI-1 WHENTITL 2 BOUND TO DNA.REF NAT.STRUCT.BIOL. V. 1 871 1994REFN ISSN 1072-8368PMID 7773776DOI 10.1038/NSB1294-871 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2f8x RBPJ crystal structure of activated notch, csl and maml on hes-1 promoter dna sequence 3.25Å AUTH Y.NAM,P.SLIZ,L.SONG,J.C.ASTER,S.C.BLACKLOWTITL STRUCTURAL BASIS FOR COOPERATIVITY IN RECRUITMENTTITL 2 OF MAML COACTIVATORS TO NOTCH TRANSCRIPTIONTITL 3 COMPLEXES.REF CELL(CAMBRIDGE,MASS.) V. 124 973 2006REFN ISSN 0092-8674PMID 16530044DOI 10.1016/J.CELL.2005.12.037 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1k78 PAX5 pax5(1-149)+ets-1(331-440)+dna 2.25Å AUTH C.W.GARVIE,J.HAGMAN,C.WOLBERGERTITL STRUCTURAL STUDIES OF ETS-1/PAX5 COMPLEX FORMATIONTITL 2 ON DNA.REF MOL.CELL V. 8 1267 2001REFN ISSN 1097-2765PMID 11779502DOI 10.1016/S1097-2765(01)00410-5 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3coa FOXO1 crystal structure of foxo1 dbd bound to ire dna 2.2Å AUTH M.M.BRENT,R.ANAND,R.MARMORSTEINTITL STRUCTURAL BASIS FOR DNA RECOGNITION BY FOXO1 ANDTITL 2 ITS REGULATION BY POSTTRANSLATIONAL MODIFICATION.REF STRUCTURE V. 16 1407 2008REFN ISSN 0969-2126PMID 18786403DOI 10.1016/J.STR.2008.06.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3gut RELA crystal structure of a higher-order complex of p50:rela bound to the hiv-1 ltr 3.59Å AUTH J.C.STROUD,A.OLTMAN,A.HAN,D.L.BATES,L.CHENTITL STRUCTURAL BASIS OF HIV-1 ACTIVATION BYTITL 2 NF-KAPPAB–A HIGHER-ORDER COMPLEX OF P50:RELA BOUNDTITL 3 TO THE HIV-1 LTR.REF J.MOL.BIOL. V. 393 98 2009REFN ISSN 0022-2836PMID 19683540DOI 10.1016/J.JMB.2009.08.023 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1nlw MXD1 crystal structure of mad-max recognizing dna 2.0Å AUTH S.K.NAIR,S.K.BURLEYTITL X-RAY STRUCTURES OF MYC-MAX AND MAD-MAXTITL 2 RECOGNIZING DNA: MOLECULAR BASES OF REGULATION BYTITL 3 PROTO-ONCOGENIC TRANSCRIPTION FACTORSREF CELL(CAMBRIDGE,MASS.) V. 112 193 2003REFN ISSN 0092-8674PMID 12553908DOI 10.1016/S0092-8674(02)01284-9 Variant Set Distributions Mapped Variants
General Structure Information 1vol GTF2B tfiib (human core domain)/tbp (a.thaliana)/tata element ternary complex 2.7Å AUTH D.B.NIKOLOV,H.CHEN,E.D.HALAY,A.A.USHEVA,K.HISATAKE,AUTH 2 D.K.LEE,R.G.ROEDER,S.K.BURLEYTITL CRYSTAL STRUCTURE OF A TFIIB-TBP-TATA-ELEMENTTITL 2 TERNARY COMPLEX.REF NATURE V. 377 119 1995REFN ISSN 0028-0836PMID 7675079DOI 10.1038/377119A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1a3q NFKB2 human nf-kappa-b p52 bound to dna 2.1Å AUTH P.CRAMER,C.J.LARSON,G.L.VERDINE,C.W.MULLERTITL STRUCTURE OF THE HUMAN NF-KAPPAB P52 HOMODIMER-DNATITL 2 COMPLEX AT 2.1 A RESOLUTION.REF EMBO J. V. 16 7078 1997REFN ISSN 0261-4189PMID 9384586DOI 10.1093/EMBOJ/16.23.7078 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3coa FOXO1 crystal structure of foxo1 dbd bound to ire dna 2.2Å AUTH M.M.BRENT,R.ANAND,R.MARMORSTEINTITL STRUCTURAL BASIS FOR DNA RECOGNITION BY FOXO1 ANDTITL 2 ITS REGULATION BY POSTTRANSLATIONAL MODIFICATION.REF STRUCTURE V. 16 1407 2008REFN ISSN 0969-2126PMID 18786403DOI 10.1016/J.STR.2008.06.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3gut RELA crystal structure of a higher-order complex of p50:rela bound to the hiv-1 ltr 3.59Å AUTH J.C.STROUD,A.OLTMAN,A.HAN,D.L.BATES,L.CHENTITL STRUCTURAL BASIS OF HIV-1 ACTIVATION BYTITL 2 NF-KAPPAB–A HIGHER-ORDER COMPLEX OF P50:RELA BOUNDTITL 3 TO THE HIV-1 LTR.REF J.MOL.BIOL. V. 393 98 2009REFN ISSN 0022-2836PMID 19683540DOI 10.1016/J.JMB.2009.08.023 Variant Set Distributions Ripley’s K Analysis Plots […]