General Structure Information
| PDB ID | 2f8x |
| HGNC Gene Label(s) | RBPJ |
| Structure Name | crystal structure of activated notch, csl and maml on hes-1 promoter dna sequence |
| Resolution | 3.25Å |
| Reference | AUTH Y.NAM,P.SLIZ,L.SONG,J.C.ASTER,S.C.BLACKLOWTITL STRUCTURAL BASIS FOR COOPERATIVITY IN RECRUITMENTTITL 2 OF MAML COACTIVATORS TO NOTCH TRANSCRIPTIONTITL 3 COMPLEXES.REF CELL(CAMBRIDGE,MASS.) V. 124 973 2006REFN ISSN 0092-8674PMID 16530044DOI 10.1016/J.CELL.2005.12.037 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 424 |
| Number Of SNVs | 39 |
| Number Of Permutations | 31878 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.404 |
| p-value | 0.158 |
COSMIC
| Number Of Residues | 424 |
| Number Of SNVs | 4 |
| Number Of Permutations | 41 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.167 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
