Assessment of Structural Intolerance and Durability
General Structure Information 2ypr FEV crystal structure of the dna binding ets domain of human protein fev 2.64Å AUTH C.D.O.COOPER,J.A.NEWMAN,H.AITKENHEAD,C.K.ALLERSTON,AUTH 2 O.GILEADITITL STRUCTURES OF THE ETS DOMAINS OF TRANSCRIPTION FACTORS ETV1,TITL 2 ETV4, ETV5 AND FEV: DETERMINANTS OF DNA BINDING AND REDOXTITL 3 REGULATION BY DISULFIDE BOND FORMATION.REF J.BIOL.CHEM. V. 290 13692 2015REFN ISSN 0021-9258PMID […]
General Structure Information 2lb2 NEDD4L structure of the second domain of human nedd4l in complex with a phosphorylated ptpy motif derived from human smad3 -1.0Å AUTH E.ARAGON,N.GOERNER,A.I.ZAROMYTIDOU,Q.XI,A.ESCOBEDO,AUTH 2 J.MASSAGUE,M.J.MACIASTITL A SMAD ACTION TURNOVER SWITCH OPERATED BY WW DOMAIN READERSTITL 2 OF A PHOSPHOSERINE CODE.REF GENES DEV. V. 25 1275 2011REFN ISSN 0890-9369PMID 21685363DOI 10.1101/GAD.2060811 Variant […]
General Structure Information 3sd4 PHF20 crystal structure of the first tudor domain of human phf20 1.93Å AUTH G.CUI,S.PARK,A.I.BADEAUX,D.KIM,J.LEE,J.R.THOMPSON,F.YAN,AUTH 2 S.KANEKO,Z.YUAN,M.V.BOTUYAN,M.T.BEDFORD,J.Q.CHENG,G.MERTITL PHF20 IS AN EFFECTOR PROTEIN OF P53 DOUBLE LYSINETITL 2 METHYLATION THAT STABILIZES AND ACTIVATES P53.REF NAT.STRUCT.MOL.BIOL. V. 19 916 2012REFN ISSN 1545-9993PMID 22864287DOI 10.1038/NSMB.2353 Variant Set Distributions Mapped Variants
General Structure Information 2kk0 ARID3A solution structure of dead ringer-like protein 1 (at-rich interactive domain-containing protein 3a) from homo sapiens, northeast structural genomics consortium (nesg) target hr4394c -1.0Å AUTH G.LIU,Y.J.HUANG,R.XIAO,D.WANG,T.B.ACTON,G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF THE ARID DOMAIN OF HUMAN AT-RICHTITL 2 INTERACTIVE DOMAIN-CONTAINING PROTEIN 3A: A HUMAN CANCERTITL 3 PROTEIN INTERACTION NETWORK TARGET.REF PROTEINS V. […]
General Structure Information 3qrf FOXP3 structure of a domain-swapped foxp3 dimer 2.8Å AUTH H.S.BANDUKWALA,Y.WU,M.FEUERER,Y.CHEN,B.BARBOZA,S.GHOSH,AUTH 2 J.C.STROUD,C.BENOIST,D.MATHIS,A.RAO,L.CHENTITL STRUCTURE OF A DOMAIN-SWAPPED FOXP3 DIMER ON DNA AND ITSTITL 2 FUNCTION IN REGULATORY T CELLS.REF IMMUNITY V. 34 479 2011REFN ISSN 1074-7613PMID 21458306DOI 10.1016/J.IMMUNI.2011.02.017 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2rt5 SPEN structural insights into the recruitment of smrt by the co-repressor sharp under phosphorylative regulation -1.0Å AUTH S.MIKAMI,T.KANABA,N.TAKIZAWA,A.KOBAYASHI,R.MAESAKI,AUTH 2 T.FUJIWARA,Y.ITO,M.MISHIMATITL STRUCTURAL INSIGHTS INTO THE RECRUITMENT OF SMRT BY THETITL 2 COREPRESSOR SHARP UNDER PHOSPHORYLATIVE REGULATIONREF STRUCTURE 2013REFN ISSN 0969-2126PMID 24268649DOI 10.1016/J.STR.2013.10.007 Variant Set Distributions Mapped Variants
General Structure Information 2l9r NKX3-1 solution nmr structure of homeobox domain of homeobox protein nkx-3.1 from homo sapiens, northeast structural genomics consortium target hr6470a -1.0Å AUTH G.LIU,R.XIAO,H.-W.LEE,K.HAMILTON,C.CICCOSANTI,H.B.WANG,AUTH 2 T.B.ACTON,J.K.EVERETT,Y.J.HUANG,G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF HOMEOBOX DOMAIN OF HOMEOBOXTITL 2 PROTEIN NKX-3.1 FROM HOMO SAPIENS, NORTHEAST STRUCTURALTITL 3 GENOMICS CONSORTIUM TARGET HR6470AREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 2x6u TBX5 crystal structure of human tbx5 in the dna-free form 1.9Å AUTH C.U.STIRNIMANN,D.PTCHELKINE,C.GRIMM,C.W.MULLERTITL STRUCTURAL BASIS OF TBX5-DNA RECOGNITION: THE T-TITL 2 BOX DOMAIN IN ITS DNA-BOUND AND -UNBOUND FORM.REF J.MOL.BIOL. V. 400 71 2010REFN ISSN 0022-2836PMID 20450920DOI 10.1016/J.JMB.2010.04.052 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3i2n WDR92 crystal structure of wd40 repeats protein wdr92 1.95Å AUTH C.XU,J.MINTITL STRUCTURE AND FUNCTION OF WD40 DOMAIN PROTEINS.REF PROTEIN CELL V. 2 202 2011REFN ISSN 1674-800XPMID 21468892DOI 10.1007/S13238-011-1018-1 Variant Set Distributions Mapped Variants
General Structure Information 3nr5 MAF1 crystal structure of human maf1 1.55Å AUTH A.VANNINI,R.RINGEL,A.G.KUSSER,O.BERNINGHAUSEN,AUTH 2 G.A.KASSAVETIS,P.CRAMERTITL MOLECULAR BASIS OF RNA POLYMERASE III TRANSCRIPTIONTITL 2 REPRESSION BY MAF1REF CELL(CAMBRIDGE,MASS.) V. 143 59 2010REFN ISSN 0092-8674PMID 20887893DOI 10.1016/J.CELL.2010.09.002 Variant Set Distributions Mapped Variants