Assessment of Structural Intolerance and Durability
General Structure Information 4fxf PKM structure of m2 pyruvate kinase in complex with phenylalanine 2.55Å AUTH H.P.MORGAN,F.J.OREILLY,M.A.WEAR,J.R.ONEILL,AUTH 2 L.A.FOTHERGILL-GILMORE,T.HUPP,M.D.WALKINSHAWTITL M2 PYRUVATE KINASE PROVIDES A MECHANISM FOR NUTRIENT SENSINGTITL 2 AND REGULATION OF CELL PROLIFERATION.REF PROC.NATL.ACAD.SCI.USA V. 110 5881 2013REFN ISSN 0027-8424PMID 23530218DOI 10.1073/PNAS.1217157110 Variant Set Distributions Mapped Variants
General Structure Information 3ewu UMPS d312n mutant of human orotidyl-5-monophosphate decarboxylase in complex with 6-acetyl-ump, covalent adduct 1.6Å AUTH D.HEINRICH,U.DIEDERICHSEN,M.G.RUDOLPHTITL LYS314 IS A NUCLEOPHILE IN NON-CLASSICAL REACTIONS OFTITL 2 OROTIDINE-5-MONOPHOSPHATE DECARBOXYLASEREF CHEMISTRY V. 15 6619 2009REFN ISSN 0947-6539PMID 19472232DOI 10.1002/CHEM.200900397 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3bg3 PC crystal structure of human pyruvate carboxylase (missing the biotin carboxylase domain at the n-terminus) 2.8Å AUTH S.XIANG,L.TONGTITL CRYSTAL STRUCTURES OF HUMAN AND STAPHYLOCOCCUSTITL 2 AUREUS PYRUVATE CARBOXYLASE AND MOLECULAR INSIGHTSTITL 3 INTO THE CARBOXYLTRANSFER REACTION.REF NAT.STRUCT.MOL.BIOL. V. 15 295 2008REFN ISSN 1545-9993PMID 18297087DOI 10.1038/NSMB.1393 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2gjx HEXB crystallographic structure of human beta-hexosaminidase a 2.8Å AUTH M.J.LEMIEUX,B.L.MARK,M.M.CHERNEY,S.G.WITHERS,D.J.MAHURAN,AUTH 2 M.N.G.JAMESTITL CRYSTALLOGRAPHIC STRUCTURE OF HUMAN BETA-HEXOSAMINIDASE A:TITL 2 INTERPRETATION OF TAY-SACHS MUTATIONS AND LOSS OF GM2TITL 3 GANGLIOSIDE HYDROLYSISREF J.MOL.BIOL. V. 359 913 2006REFN ISSN 0022-2836PMID 16698036DOI 10.1016/J.JMB.2006.04.004 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2clp AKR7A3 crystal structure of human aflatoxin b1 aldehyde reductase member 3 3.0Å AUTH J.E.DEBRECZENI,C.JOHANSSON,K.KAVANAGH,A.TURNBULL,AUTH 2 E.PAPAGRIGORIOU,F.VON DELFT,A.EDWARDS,C.ARROWSMITH,AUTH 3 J.WEIGELT,M.SUNDSTROM,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN AFLATOXIN B1 ALDEHYDE REDUCTASETITL 2 MEMBER 3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4jih AKR1B10 crystal structure of akr1b10 complexed with nadp+ and epalrestat 2.3Å AUTH L.ZHANG,H.ZHANG,Y.ZHAO,Z.LI,S.CHEN,J.ZHAI,Y.CHEN,W.XIE,AUTH 2 Z.WANG,Q.LI,X.ZHENG,X.HUTITL INHIBITOR SELECTIVITY BETWEEN ALDO-KETO REDUCTASETITL 2 SUPERFAMILY MEMBERS AKR1B10 AND AKR1B1: ROLE OF TRP112TITL 3 (TRP111).REF FEBS LETT. V. 587 3681 2013REFN ISSN 0014-5793PMID 24100137DOI 10.1016/J.FEBSLET.2013.09.031 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2bp1 AKR7A2 structure of the aflatoxin aldehyde reductase in complex with nadph 2.4Å AUTH J.E.DEBRECZENI,P.LUKACIK,K.KAVANAGH,E.DUBININA,J.BRAY,AUTH 2 S.COLEBROOK,A.HARONITI,A.EDWARDS,C.ARROWSMITH,M.SUNDSTROM,AUTH 3 F.VON DELFT,O.GILEADI,U.OPPERMANNTITL STRUCTURE OF THE AFLATOXIN ALDEHYDE REDUCTASE IN COMPLEXTITL 2 WITH NADPHREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4gqb PRMT5 crystal structure of the human prmt5:mep50 complex 2.06Å AUTH S.ANTONYSAMY,Z.BONDAY,R.M.CAMPBELL,B.DOYLE,Z.DRUZINA,AUTH 2 T.GHEYI,B.HAN,L.N.JUNGHEIM,Y.QIAN,C.RAUCH,M.RUSSELL,AUTH 3 J.M.SAUDER,S.R.WASSERMAN,K.WEICHERT,F.S.WILLARD,A.ZHANG,AUTH 4 S.EMTAGETITL CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 109 17960 2012REFN ISSN 0027-8424PMID 23071334DOI 10.1073/PNAS.1209814109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants